Secure synchronization control for complex dynamic networks with event-triggered communication strategy under multi-channel denial-of-service attacks.

This article addresses the secure synchronization problem for complex dynamical networks (CDNs) with observer-based event-triggered communication strategy (ETCS) under multi-channel denial-of-service attacks (MCDSAs). Due to external environmental interference, the observers are designed to accurately estimate the state of the network systems. Meanwhile, the impact of cyber attacks on system security is considered.

Solution of plastic zone range in soft rock tunnel surroundings considering joint damage.

Based on the Hohai model, a creep constitutive model of viscoelastic-plastic soft rock with joint fracture damage is proposed to solve the rheological failure problem in soft rock tunnels surrounding rock. Based on the proposed creep model of rock with joint damage and the current analytical analysis method of circular tunnel, the analytical formulas of viscoelastic-viscoplastic stress and displacement of circular tunnel with joint damage surrounding rock are derived. ABAQUS finite element software is used to simulate the excavation of surrounding rock with different joint angles.

MnO-based dual channel surface plasmon resonance fiber sensor for trace glutathione and refractive index detection.

Glutathione (GSH) plays vital role in human biological systems, so its rapid and sensitive detection is necessary for health condition monitoring. In this work, a simple structure for dual channel GSH and refractive index (RI) detection is proposed. By introducing Au-MnO thin film coating on the fiber surface for the first time, GSH solution would lead to the dissolution of MnO, the change in GSH levels could be monitored over a short period in channel 2.

Establishment and engineering application of viscoelastic-plastic constitutive laws for creep modeling in interbedded rock masses.

In order to study the creep behavior of the surrounding rock of the interbedded rock mass tunnel considering the time-dependent deformation, this paper proposes a viscoelastic-plastic seven-element model considering the stress threshold, and derives and establishes its creep equation under three-dimensional stress state. At the same time, the UMAT (User-defined Material) subroutine of the model is developed based on the ABAQUS software. The rationality of the seven-element model and the effectiveness of the subprogram are verified by rheological test results.

KLF4 facilitates chromatin accessibility remodeling in porcine early embryos.

Chromatin accessibility remodeling driven by pioneer factors is critical for the development of early embryos. Current studies have illustrated several pioneer factors as being important for agricultural animals, but what are the pioneer factors and how the pioneer factors remodel the chromatin accessibility in porcine early embryos is not clear. By employing low-input DNase-seq (liDNase-seq), we profiled the landscapes of chromatin accessibility in porcine early embryos and uncovered a unique chromatin accessibility reprogramming pattern during porcine preimplantation development.

Neural grafts containing exosomes derived from Schwann cell-like cells promote peripheral nerve regeneration in rats.

Background: Schwann cell-like cells (SCLCs), differentiated from mesenchymal stem cells, have shown promising outcomes in the treatment of peripheral nerve injuries in preclinical studies. However, certain clinical obstacles limit their application. Hence, the primary aim of this study was to investigate the role of exosomes derived from SCLCs (SCLCs-exo) in peripheral nerve regeneration.

Transcriptomic and Physiological Analyses Reveal the Molecular Mechanism through Which Exogenous Melatonin Increases Drought Stress Tolerance in Chrysanthemum.

( (Ramat.) Hemsl.) is an important species in China's flower industry, and drought stress seriously affects the growth, quality, yield, and geographical distribution of this species.

GATA2 promotes oxidative stress to aggravate renal ischemia-reperfusion injury by up-regulating Redd1.

Renal ischemia-reperfusion injury (RIRI) is a common pathophysiological process, and it is also an important cause of acute renal failure. Therefore, finding an effective therapeutic target for RIRI is extremely urgent. In our study, we constructed hypoxia-reoxygenation (HR) model in vitro and a renal ischemia-reperfusion (IR) model in vivo.

Emodin Ameliorates High Glucose-Induced Podocyte Apoptosis via Regulating AMPK/mTOR-Mediated Autophagy Signaling Pathway.

Objective: To investigate the effect of emodin on high glucose (HG)-induced podocyte apoptosis and whether the potential anti-apoptotic mechanism of emodin is related to induction of adenosine-monophosphate-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR)-mediated autophagy in podocytes (MPC5 cells) in vitro.

Methods: MPC5 cells were treated with different concentrations of HG (2.5, 5, 10, 20, 40, 80 and 160 mmol/L), emodin (2, 4, 8 µ mol/L), or HG (40 mmol/L) and emodin (4 µ mol/L) with or without rapamycin (Rap, 100 nmol/L) and compound C (10 µ mol/L).

Coordination of zygotic genome activation entry and exit by H3K4me3 and H3K27me3 in porcine early embryos.

Histone modifications are critical epigenetic indicators of chromatin state associated with gene expression. Although the reprogramming patterns of H3K4me3 and H3K27me3 have been elucidated in mouse and human preimplantation embryos, the relationship between these marks and zygotic genome activation (ZGA) remains poorly understood. By ultra-low-input native chromatin immunoprecipitation and sequencing, we profiled global H3K4me3 and H3K27me3 in porcine oocytes and in vitro fertilized (IVF) embryos.

Hierarchical Accumulation of Histone Variant H2A.Z Regulates Transcriptional States and Histone Modifications in Early Mammalian Embryos.

Early embryos undergo extensive epigenetic reprogramming to achieve gamete-to-embryo transition, which involves the loading and removal of histone variant H2A.Z on chromatin. However, how does H2A.

DNMT3a negatively regulates PTEN to activate the PI3K/AKT pathway to aggravate renal fibrosis.

Background: Renal fibrosis has become one of the major diseases threatening global public health and harming human life and health. PTEN methylation plays an important role in fibrotic diseases of many organs. However, the relationship between PTEN methylation and renal fibrosis is still elusive.

First-Principles Study of Electronic Properties of Substitutionally Doped Monolayer SnP.

SnP has a great prospect in electronic and thermoelectric device applications due to its moderate band gap, high carrier mobility, absorption coefficients, and dynamical and chemical stability. Doping in two-dimensional semiconductors is likely to display various anomalous behaviors when compared to doping in bulk semiconductors due to the significant electron confinement effect. By introducing foreign atoms from group III to VI, we can successfully modify the electronic properties of two-dimensional SnP.

Selective autophagic degradation of ACLY (ATP citrate lyase) maintains citrate homeostasis and promotes oocyte maturation.

Macroautophagy/autophagy is a cellular and energy homeostatic mechanism that contributes to maintain the number of primordial follicles, germ cell survival, and anti-ovarian aging. However, it remains unknown whether autophagy in granulosa cells affects oocyte maturation. Here, we show a clear tendency of reduced autophagy level in human granulosa cells from women of advanced maternal age, implying a potential negative correlation between autophagy levels and oocyte quality.

Circ_0000064 promotes high glucose-induced renal tubular epithelial cells injury to facilitate diabetic nephropathy progression through miR-532-3p/ROCK1 axis.

Background: Circular RNA (circRNA) has been shown to mediate diabetic nephropathy (DN) development by regulating renal tubular epithelial cells (RTECs) injury. However, the role and mechanism of circ_0000064 in high glucose (HG)-induced RTECs injury have not been fully elucidated.

Methods: Human RTECs (HK-2) were exposed to HG to induce cell injury.

Efficacy of Restricting Dietary Protein Intake Combined with Buyang Huanwu Decoction in Treating Diabetic Nephropathy and Its Effect on Patients' Inflammatory Factor Levels.

Objective: To study the efficacy of restricting dietary protein intake combined with Buyang Huanwu decoction in treating diabetic nephropathy (DN) and its effect on patients' inflammatory factor levels.

Methods: The medical data of 150 DN patients treated in (June 2018-May 2021) were retrospectively analyzed. All patients received regular therapy, those who received the intervention of restricting dietary protein intake were included in the control group ( = 75), and on this basis, those treated with Buyang Huanwu decoction were included in the experimental group ( = 75), so as to scientifically evaluate their efficacy and inflammatory factor levels after treatment.

Design and Fabrication of a Microfluidic Chip for Particle Size-Exclusion and Enrichment.

Based on the size of particles, a microfluidic chip integrating micro particles capture, controlled release and counting analysis was designed and fabricated in this paper. The chip is composed of a polydimethylsiloxane (PDMS) cover sheet and a PDMS substrate. The PDMS substrate is made of a sample inlet, microfluidic channels, a micropillar array, a three-dimensional (3D) focusing channel, and a sample outlet.

[Application of modified three longitudinal and five transverse method in perforating branch location before anterolateral thigh perforator flap repair].

Objective: To explore the feasibility and accuracy of modified three longitudinal and five transverse method in locating perforating branches before anterolateral thigh perforator flap (ALTP) repair.

Methods: Between January 2019 and December 2019, 41 patients with skin and soft tissue defects were repaired with ALTP. There were 31 males and 10 females.

State-based event-triggered consensus strategy for Takagi-Sugeno fuzzy fractional-order multiagent systems with switching topologies.

This article addresses the event-triggered consensus problem for Takagi-Sugeno fuzzy fractional-order multiagent systems with switching topologies. First, to effectively avoid the frequent communication among agents, a state-based event-triggered consensus strategy is designed, which uses the local information from neighboring agents at sampling moments. Then, several sufficient conditions, which rely on the fractional derivative number and time delay information, are presented to guarantee the consensus of fractional-order multiagent systems based on Takagi-Sugeno fuzzy model.

Hybrid Event-Triggered and Impulsive Control Strategy for Multiagent Systems With Switching Topologies.

This article investigates the hybrid event-triggered and impulsive consensus problems for leaderless and leader-following multiagent systems (MASs) with switching topologies. Based on the state information of neighboring agents at event-triggered moments and impulsive instants, a hybrid event-triggered and impulsive control strategy (HETICS) is designed to reduce the communication frequency between neighboring agents and to ensure consensus of leaderless and leader-following MASs. By utilizing the Lyapunov direct method, some consensus criteria are obtained for leaderless and leader-following MASs with switching topologies.

Structural and Electronic Properties of Heterostructures Composed of Antimonene and Monolayer MoS.

Antimonene is found to be a promising material for two-dimensional optoelectronic equipment due to its broad band gap and high carrier mobility. The van der Waals heterostructure, as a unique structural unit for the study of photoelectric properties, has attracted great attention. By using ab initio density functional theory with van der Waals corrections, we theoretically investigated the structural and electronic properties of the heterostructures composed of antimonene and monolayer MoS.

Anti-FXa-IIa activity test in Asian and its potential role for drug adherence evaluation in patients with direct oral anticoagulants: a nationwide multi-center synchronization study.

Background: The data of anti-FXa-IIa activity detection in Asian population is insufficient, and its potential role for drug adherence evaluation in patients with direct oral anticoagulants (DOACs) remains unclear. This study carried out multi-center anti-FXa-IIa activity detection in Asian, aiming to explore its applicability in Asian population and find its role in adherence evaluation.

Methods: We assessed patients' self-reported adherence using the Morisky, Green, and Levine Adherence Scale (MGLS) from six hospitals.

Tunable Electronic Properties of Type-II SiS/WSe Hetero-Bilayers.

First-principle calculations based on the density functional theory (DFT) are implemented to study the structural and electronic properties of the SiS/WSe hetero-bilayers. It is found that the AB-2 stacking model is most stable among all the six SiS/WSe heterostructures considered in this work. The AB-2 stacking SiS/WSe hetero-bilayer possesses a type-II band alignment with a narrow indirect band gap (0.