Pre-activated nanoparticles with persistent luminescence for deep tumor photodynamic therapy in gallbladder cancer.

Phototherapy of deep tumors still suffers from many obstacles, such as limited near-infrared (NIR) tissue penetration depth and low accumulation efficiency within the target sites. Herein, stimuli-sensitive tumor-targeted photodynamic nanoparticles (STPNs) with persistent luminescence for the treatment of deep tumors are reported. Purpurin 18 (Pu18), a porphyrin derivative, is utilized as a photosensitizer to produce persistent luminescence in STPNs, while lanthanide-doped upconversion nanoparticles (UCNPs) exhibit bioimaging properties and possess high photostability that can enhance photosensitizer efficacy.

A benzo BODIPY based fluorescent probe for selective visualization of hypochlorous acid in living cells and zebrafish.

Hypochlorous acid (HOCl) is an essential endogenous reactive oxygen species in biological systems, playing a critical role in various physiological processes. Real-time monitoring of HOCl concentration in living organisms is essential for understanding its biological functions and pathological roles. In this study, we developed a novel fluorescent probe based on benzobodipy, BBDP, for rapid and sensitive detection of HOCl in aqueous solutions.

A new benzo-bodipy based fluorescent probe for the highly sensitive detection of hypochlorous acid and its application in the living cells and zebrafish imaging.

Due to the highly significant biological activity of hypochlorous acid, the monitoring of its concentration in vivo has received extensive attention. In this work, a photoinduced electron transfer (PeT) based benzo-bodipy fluorescent probe BBy-T has been developed for the rapid, sensitive, and selective detection of HClO in an aqueous solution. Based on the HClO-specific oxidation reaction, BBy-T exhibited a distinct fluorescence turn-on response to HClO with a remarkable Stokes shift (84 nm), immediate response (less than 20 s), and low detection limit (13.