A novel ratiometric sensor for fluorimetric and visual dual-mode detection of Al in environmental water based on the target-regulated formation of Eu MOFs.

Herein, a novel ratiometric sensor for fluorimetric and smartphone-assisted visual detection of Al in environmental water was developed based on the target-regulated formation of Eu metal-organic frameworks (Eu MOFs). By employing 2-[4-(2-hydroxyethyl) piperazin-1-yl] ethanesulfonic acid (Hepes), Eu and tetracycline (TC) as raw materials, Eu MOFs with red emission were facilely synthesized through the coordination of Eu with Hepes and TC. However, upon the introduction of Al, a higher affinity of TC towards Al resulted in the formation of a TC-Al complex with green fluorescence and inhibited the generation of Eu MOFs.

Enhanced visible light photo-Fenton catalysis by Fe-doping oligo-layer natural molybdenite with efficient carrier spatial-driven Fe/Fe cycle.

Developing cost-effective and efficient photo-Fenton catalysts is crucial for advancing photo-Fenton technology. MoS is a representative transition metal disulfide with attractive photoresponsiveness, making it ideal for preparing composite photo-Fenton catalysts. In this study, natural molybdenite was innovatively utilized as a source of MoS (OM) to synthesize a low-cost and efficient Fe@MoS (OMF) composite photo-Fenton catalyst by comminution and adsorption, which was then applied to the remediation of antibiotic-contaminated water.

A facile fluorescence Eu MOF sensor for ascorbic acid and ascorbate oxidase detection.

In this work, a facile fluorescence Eu-based metal-organic framework (Eu MOF) sensor for ascorbic acid (AA) and ascorbate oxidase (AAO) detection was developed. The fluorescence of the Eu MOF could be effectively quenched by Ce but not by Ce at an appropriate concentration, and thus, when the reductant AA was added into the solution containing Ce, Ce was chemically reduced to Ce, which induced the decreased fluorescence signal of the Eu MOF. However, when AAO was introduced, AA was effectively oxidized to dehydroascorbic acid (DHAA) under the catalysis of AAO, and thus, Ce could not be reduced, resulting in the fluorescence restoration of the Eu MOF.

Engineered FGF19 protects against intrahepatic cholestatic liver injury in ANIT-induced and Mdr2-/- mice model.

Background: The major safety concern of the clinical application of wild type FGF19 (FGF19) emerges given that its extended treatment causes hepatocellular carcinoma. Therefore, we previously generated a safer FGF19 variant - FGF19, which have same effects on glycemic control and bile acid production but much less mitogenic activity. However, it remains unclear as to whether FGF19 ameliorates intrahepatic cholestasis.

Modified In Vivo Matrix Gel Plug Assay for Angiogenesis Studies.

Several models have been developed to investigate angiogenesis in vivo. However, most of these models are complex and expensive, require specialized equipment, or are hard to perform for subsequent quantitative analysis. Here we present a modified matrix gel plug assay to evaluate angiogenesis in vivo.