Publications by authors named "Taochun Ye"
Background: Atherosclerosis (AS) serves as the primary pathological basis for various cardiovascular and cerebrovascular diseases. Impaired efferocytosis by macrophages within AS plaques exacerbates lipid metabolism disorders and inflammatory responses. Huoxue Tongluo Tablet (HXTL), a traditional Chinese medicine formula, has shown efficacy in treating AS and modulating macrophage function.
View Article and Find Full Text PDFAims: Patients with heart valvular regurgitation is increasing; early screening of potential patients developing heart failure (HF) is crucial.
Methods: From 1 November 2019 to 31 October 2023, a total of 509 patients with heart valvular regurgitation hospitalized in the Department of Cardiovascular Disease of the First Affiliated Hospital of Guangzhou University of Traditional Medicine were enrolled. Three hundred fifty-six cases were selected as the training set for modelling, and 153 cases were selected as the validation set for the internal validation of the model.
Background: Heart failure (HF) is a serious and terminal stage of various cardiac diseases and the most common complication of coronary heart disease (CHD). Previous clinical studies have shown that Qishen Yiqi dropping pills (QSYQ) have the effect of treating chronic heart failure. This study aims to evaluate the clinical efficacy, safety and optimal effective dose of QSYQ in treating CHD complicating chronic HF with reduced ejection fraction (HFrEF).
View Article and Find Full Text PDFArticle Synopsis
- Diabetic cardiomyopathy (DCM) is a common and serious heart condition linked to diabetes, with limited treatment options and high rates of complications.
- The article discusses how inflammation significantly influences the development and worsening of DCM by affecting heart cells and vessels.
- It reviews recent research on the role of inflammation and considers potential benefits of existing anti-inflammatory drugs for managing DCM to help improve clinical practices.
Article Synopsis
- The study investigates the relationship between dietary total antioxidant capacity (DTAC) and mortality risk in chronic kidney disease (CKD) patients, focusing on two cohorts analyzed from the National Health and Nutrition Examination Survey.
- Results indicated that higher dietary antioxidant intake is associated with lower all-cause mortality in early-stage CKD (stages 1-2), but no such benefits were found for patients in more advanced stages (3-5).
- The findings suggest that moderate antioxidant intake may be beneficial for early-stage CKD patients, but more research is needed to determine its long-term effects on those with severe CKD.
Article Synopsis
- Muscle wasting linked to chronic kidney disease (CKD) and dialysis can lead to increased health risks, but the role of ferroptosis (a type of cell death) in this process is still being researched as a potential treatment target.
- The study involved analyzing the skeletal muscle of mice with CKD to check for signs of ferroptosis and to screen traditional Chinese herbs for their ability to prevent muscle wasting and ferroptosis.
- Results showed that a compound called Lobetyolin (LBT) significantly reduced muscle injury by inhibiting ferroptosis in both mice and lab cells, suggesting its potential as a therapeutic agent against muscle wasting related to CKD.
Heme in Cardiovascular Diseases: A Ubiquitous Dangerous Molecule Worthy of Vigilance.
Front Cell Dev Biol
January 2022
Heme, the protoporphyrin IX iron complex is widely present in the human body and it is involved in oxygen storage, electron transfer, and enzymatic reactions. However, free heme can be toxic as it catalyzes the production of reactive oxygen species, oxidizes lipids and proteins, and causes DNA damage, thereby inducing a pro-inflammatory environment. The generation, metabolism, and degradation of heme in the human body are regulated by precise mechanisms to ensure that heme remains non-toxic.
View Article and Find Full Text PDFEthnopharmacological Relevance: Sclederma of Poria cocos (Hoelen) has been used as a diuretic in traditional Asian medicine. However, the underlying mechanism by which Sclederma of Poria cocos (hoelen) exerts its diuretic effect has not been well identified. The aim of the present study was to evaluate the effects of Sclederma of Poria cocos (hoelen) in rats with chronic heart failure (CHF) induced by acute myocardial infarction and to investigate the underlying mechanisms.
View Article and Find Full Text PDF[Variation of serum soluble CD14 levels in patients with chronic heart failure].
Nan Fang Yi Ke Da Xue Xue Bao
July 2008
Objective: To analyze the patterns of serum soluble CD14 (sCD14) and C-reactive protein (CRP) alterations in patients with chronic heart failure (CHF) and investigate the correlations of sCD14 variation to the etiology, clinical symptoms, and the number of mononuclear cells in these patients.
Methods: This study involved 246 CHF patients stratified according to their etiology and clinical symptoms, with 107 normal individuals serving as the control group. Blood samples were collected from these patients the next day after admission and also from the control subjects for measuring serum sCD14 and CPR levels using enzyme-linked immunosorbent assay (ELISA) and rate nephelometry, respectively.