Publications by authors named "Tao-chun Ye"
Article Synopsis
- Diabetic cardiomyopathy (DCM) is a common and serious heart condition linked to diabetes, with limited treatment options and high rates of complications.
- The article discusses how inflammation significantly influences the development and worsening of DCM by affecting heart cells and vessels.
- It reviews recent research on the role of inflammation and considers potential benefits of existing anti-inflammatory drugs for managing DCM to help improve clinical practices.
Article Synopsis
- The study investigates the relationship between dietary total antioxidant capacity (DTAC) and mortality risk in chronic kidney disease (CKD) patients, focusing on two cohorts analyzed from the National Health and Nutrition Examination Survey.
- Results indicated that higher dietary antioxidant intake is associated with lower all-cause mortality in early-stage CKD (stages 1-2), but no such benefits were found for patients in more advanced stages (3-5).
- The findings suggest that moderate antioxidant intake may be beneficial for early-stage CKD patients, but more research is needed to determine its long-term effects on those with severe CKD.
Article Synopsis
- Muscle wasting linked to chronic kidney disease (CKD) and dialysis can lead to increased health risks, but the role of ferroptosis (a type of cell death) in this process is still being researched as a potential treatment target.
- The study involved analyzing the skeletal muscle of mice with CKD to check for signs of ferroptosis and to screen traditional Chinese herbs for their ability to prevent muscle wasting and ferroptosis.
- Results showed that a compound called Lobetyolin (LBT) significantly reduced muscle injury by inhibiting ferroptosis in both mice and lab cells, suggesting its potential as a therapeutic agent against muscle wasting related to CKD.
Ethnopharmacological Relevance: Sclederma of Poria cocos (Hoelen) has been used as a diuretic in traditional Asian medicine. However, the underlying mechanism by which Sclederma of Poria cocos (hoelen) exerts its diuretic effect has not been well identified. The aim of the present study was to evaluate the effects of Sclederma of Poria cocos (hoelen) in rats with chronic heart failure (CHF) induced by acute myocardial infarction and to investigate the underlying mechanisms.
View Article and Find Full Text PDF[Variation of serum soluble CD14 levels in patients with chronic heart failure].
Nan Fang Yi Ke Da Xue Xue Bao
July 2008
Objective: To analyze the patterns of serum soluble CD14 (sCD14) and C-reactive protein (CRP) alterations in patients with chronic heart failure (CHF) and investigate the correlations of sCD14 variation to the etiology, clinical symptoms, and the number of mononuclear cells in these patients.
Methods: This study involved 246 CHF patients stratified according to their etiology and clinical symptoms, with 107 normal individuals serving as the control group. Blood samples were collected from these patients the next day after admission and also from the control subjects for measuring serum sCD14 and CPR levels using enzyme-linked immunosorbent assay (ELISA) and rate nephelometry, respectively.