Publications by authors named "Tao-Lin Qing"
Article Synopsis
- Multiwalled carbon nanotubes (MWCNTs) have various applications but raise toxicity concerns due to potential lung inflammation from inhalation.
- Celastrol, a natural anti-inflammatory plant compound, significantly reduced inflammatory cells and cytokine levels in mice lungs exposed to MWCNTs.
- The study revealed that celastrol works by inhibiting the NF-κB-signaling pathway, showcasing its potential as a treatment to prevent MWCNT-related lung inflammation.
Photothermal therapy (PTT) of nanomaterials is an emerging novel therapeutic strategy for breast cancer. However, there exists an urgent need for appropriate strategies to enhance the antitumor efficacy of PTT and minimize damage to surrounding normal tissues. Piezo1 might be a promising novel photothermal therapeutic target for breast cancer.
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- MWCNTs cause oxidative stress by increasing reactive oxygen species (ROS), leading to decreased cell viability and cytotoxicity.
- Celastrol, a plant-derived antioxidant, reduces ROS production and protects against MWCNT-induced damage by promoting Nrf2 translocation and HO-1 expression.
- In animal studies, celastrol reduced lung inflammation and increased levels of antioxidants, showing its potential in mitigating the harmful effects of MWCNTs.
Article Synopsis
- Multiwalled carbon nanotubes (MWCNTs) are being studied for their potential use in drug delivery and medical imaging, but their impact on blood vessel cells (endothelial cells) hasn't been fully understood.
- The research revealed that MWCNTs can enter these cells and disrupt their functions, specifically hindering their ability to form new blood vessels (angiogenesis) in both lab and animal studies.
- The study found that the harmful effects of MWCNTs on endothelial cells are linked to decreased levels of vascular endothelial growth factor (VEGF), but introducing recombinant VEGF can help restore cell function and promote angiogenesis.
Added risk portended by diabetes in addition to hypertension has been related to an amplification of endothelial dysfunction. β-blockers are widely used for cardiovascular diseases and improve the endothelial function compared with a placebo. However, the effect of β-blockers on the endothelial progenitor cells (EPCs) function in diabetes is still unknown.
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