Wafer-scale platform for on-chip 3D radio frequency lumped passive components using metal self-rolled-up membrane technique.

A wafer-scale metal self-rolled-up membrane platform has been proposed for the design and fabrication of radio-frequency on-chip lumped passive components, which is demonstrated on a commercial 4-inch sapphire batch fabrication line. Compared to the traditional methodology including planar or SiN based self-rolled-up membrane processing technologies to obtain the most basic passive lumped components, such as inductors and capacitors on the chip, this platform enables more compact three-dimensional construction of the component device structure with higher electrical performance. For demonstration, batches of wafer-scale RF inductors and capacitors are fabricated through precise design based on electromagnetic analysis.

Organelle-targeted BODIPY-conjugated platinum(IV) anticancer prodrugs for overcoming drug resistance.

Platinum-based chemotherapy, despite being a cornerstone of cancer treatment, faces significant challenges due to acquired drug resistance. To address this issue, we have designed three organelle-targeting platinum(IV) prodrugs conjugated with BODIPY fluorophores, enabling spatiotemporal control through green light irradiation. These BODIPY-Pt(IV) conjugates exhibit excellent stability in PBS buffer, demonstrating resilience under physiological conditions.

Cell Function Graphics: TOGGLE delineates fate and function within individual cell types via single-cell transcriptomics.

Functional RNA plays a crucial role in regulating cellular processes throughout the life cycle of a cell. Identifying functional changes at each stage-from inception to development to maturation, functional execution, and eventual death or pathological transformation-often requires systematic comparisons of functional expression across cell populations. However, because cells of the same type often exhibit similar gene expression patterns regardless of function or fate, it is challenging to distinguish the stages of cellular fate or functional states within the same cell type, which also limits our understanding of cellular memory.

Harnessing pea proteins for thermo-reversible gels: Novel strategy and molecular principle.

Thermo-reversible gels (such as gelatin) have a wide range of applications in the food and pharmaceutical fields. This work reports a thermo-reversible gel prepared with pea protein isolate fractionated using ionic strength-shifting method (I: 0.5 → 0.

Quercetagetin alleviates inflammatory osteoclastogenesis and collagen antibody-induced arthritis via Nrf2 signaling and Pten/AKT/Nfatc1 axis.

Purpose: Quercetagetin, a flavonoid derived from the natural herb Flos eriocauli, is used in traditional Chinese medicine for its fire-purging (anti-inflammation) and wind-expelling (pain-alleviating) properties. However, its potential effects concerning rheumatoid arthritis (RA) remain underexplored. This study was designed to elucidate the potential associations between Quercetagetin and RA, establishing the therapeutic potential of Quercetagetin and related mechanisms in RA treatment.

The clinical value of α-hydroxybutyrate dehydrogenase, cardiac troponin I, and B-type natriuretic peptide in perioperative diagnosis of heart failure in children with congenital heart disease.

Objective: This study evaluates the clinical value of α-Hydroxybutyrate Dehydrogenase (α-HBDH), Cardiac Troponin I (cTnI), and B-Type Natriuretic Peptide (BNP) in the perioperative diagnosis of heart failure in children with congenital heart disease (CHD).

Methods: A retrospective analysis was performed on data from 107 children with CHD who underwent surgery between March 2022 and March 2023. Patients were categorized based on the European Society of Cardiology (ESC) cardiac function grading into three groups (Grades I-III) and further into heart failure (HF) and non-HF groups.

Adaptive Stepwise Feature Selection Approach for EEG-Based Epileptic Seizure Classification.

Recent advancements in feature selection (FS) optimization algorithms have influenced the field of epileptic seizure classification. However, integrating these optimization algorithms into machine learning (ML) models often creates time complexity, limiting their clinical deployment. To address this issue, we propose an innovative adaptive stepwise FS method tailored for epileptic seizure detection (ESD).

Upcycling of Livestock Industry Blood Waste into Bioplastics: Plasma Protein-Based Amyloid Fibrils.

This study presents a novel approach to harnessing the underutilized resource of livestock blood plasma proteins to produce bioplastic films based on amyloid fibrils. Upon acidic heating, a 20-h incubation period resulted in mature, semiflexible fibrils with an average length of 0.65 μm and a persistence length of 261 nm.

The transcription factor CitPH4 regulates plant defense-related metabolite biosynthesis in citrus.

Wild citrus (Citrus L.) exhibits high disease resistance accompanied by high-acidity fruit, whereas cultivated citrus produces tastier fruit but is more susceptible to disease. This is a common phenomenon, but the underlying molecular mechanisms remain unknown.

Multi-dimensional donor engineering of NIR-II AIEgens for multimodal phototheranostics of orthotopic breast cancer.

"One-for-all" multimodal phototheranostic agents, which integrate multiple photodiagnostic and phototherapeutic functionalities into a single component, have emerged as promising platforms for advancing cancer treatment. Among these, agents featuring second near-infrared (NIR-II) emission are particularly appealing due to their superior tissue penetration depth and high signal-to-background ratio (SBR). However, most reported NIR-II fluorophores suffer from severely imbalanced radiative and non-radiative excited-state energy dissipation in biological environments, resulting in extremely low fluorescence quantum yields (QYs) and limited diagnostic efficacy.

LncRNA NAV2-AS2 is critical for fibroblast-to-myofibroblast transition and cardiac fibrosis.

Cardiac fibrosis is a key feature of cardiac remodeling in advanced stages of various cardiovascular diseases. Long non-coding RNAs (lncRNAs) have been shown to play a critical role in the pathogenesis of cardiac fibrosis. The present study uncovered lncRNA NAV2-AS2 as a newfound regulator of cardiac fibrosis, governing fibroblast proliferation and fibroblast-to-myofibroblast transition (FMT).

Enabling Solid-Electrolyte Interphase Formation Prior to Water Reduction in Aqueous Zinc Batteries by Mild Protic Chemistry.

Challenges like hydrogen evolution reaction (HER) and dendrite formation on zinc anodes hinder the practical application of aqueous zinc batteries (AZBs), primarily due to the lack of an exceptional passivating solid-electrolyte interphase (SEI). To effectively prevent water decomposition, it is essential to in situ construct SEI prior to water reduction. This study shifts the focus from aprotic to protic SEI chemistry and predicts reduction potentials of mild protic compounds using thermodynamics.

Vascular penetration sign: dual-phase enhanced CT manifestations of atypical liver abscess caused by Klebsiella pneumoniae.

Objectives: The aim of this study was to investigate the multislice spiral computed tomography (MSCT) features of atypical liver abscesses caused by Klebsiella pneumoniae (KP).

Methods: A retrospective review was conducted on patients with atypical KP-caused liver abscesses, as verified by biopsy or surgery, from October 2019 to December 2023. All patients underwent dual-phase enhanced CT scan, and MSCT findings were analysed.

Preparation and Properties of Sodium Carboxymethyl Cellulose Microspheres by Dropping Method.

Sodium carboxymethyl cellulose (CMC) is the most extensively utilized derivative of cellulose. In this study, an innovative approach was employed to disperse a CMC aqueous solution into olive oil in the form of liquid droplets, resulting in the direct formation of CMC microspheres after drying. The effects of CMC concentration and needle aperture size on microsphere formation were systematically investigated, showing that the particle size of the microspheres decreased with an increase in CMC concentration and a decrease in needle aperture.

"Candidatus Liberibacter asiaticus" Infection Induces Citric Acid Accumulation and Immune Responses Mediated by the Transcription Factor CitPH4.

Citrus huanglongbing (HLB), caused by "Candidatus Liberibacter" spp., is one of the most disastrous citrus diseases worldwide. HLB-affected citrus fruits are significantly more acidic than healthy fruits.

[Chemical constituents from Alternaria alternata and their activity of down-regulating TMSB10 expression].

This study investigated the secondary metabolites in the product of rice fermentation with Alternaria alternata and their activity of down-regulating thymosin beta 10(TMSB10) protein expression. The secondary metabolites of A. alternata were separated and purified by various chromatographic separation techniques, including silica gel column chromatography, Sephadex LH-20 column chromatography, and semi-preparative high-performance liquid chromatography.

Clinical analysis of 101 cases of infectious endophthalmitis.

This study aimed to analyze the pathogenesis, clinical features, and treatment of infectious endophthalmitis and provide reference data for its prevention and treatment. The study retrospectively analyzed 101 cases of infectious endophthalmitis patients who received treatment at the Second People's Hospital of Jinan from January 2020 to December 2022, including pathogenic factors, microbiology, treatment, and prognosis of the patients. We found that traumatic endophthalmitis accounted for 48.

Benefits of entecavir therapy in HBV-related hepatocellular carcinoma patients with compensated cirrhosis after hepatectomy: A ten-year retrospective cohort study.

Introduction: Data on the impact of antiviral therapy(AVT) on the long-term outcomes of hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC) patients with historically-proved cirrhosis after hepatectomy are limited. We aimed to determine the effect of AVT on resected HCC in the background of HBV-related cirrhosis.

Materials And Methods: A total of 1396 patients with HBV-related cirrhotic HCC undergoing curative resection were categorized into AVT and no-AVT groups retrospectively.

Neuropsychiatric adverse events associated with Glucagon-like peptide-1 receptor agonists: a pharmacovigilance analysis of the FDA Adverse Event Reporting System database.

Background: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used due to their profound efficacy in glycemic control and weight management. Real-world observations have revealed potential neuropsychiatric adverse events (AEs) associated with GLP-1RAs. This study aimed to comprehensively investigate and characterize these neuropsychiatric AEs with GLP-1RAs.

Enhanced myofibroblast differentiation of eMSCs in intrauterine adhesions.

Background: Intrauterine adhesions (IUA) is one of the most common gynecological diseases and main causes of uterine infertility. Among proposed hypotheses on IUA development, the reduced endometrial regeneration resulting from loss of functional stem cells has been proposed as the key factor affecting the IUA prognosis. However, the underlying mechanisms mostly remain unclear.

Assessment of responses of cultured benthic foraminiferal communities to copper pollution through environmental RNA metabarcoding analysis.

Copper (Cu) is an essential trace element and can accumulate in sedimentary environments. However, beyond a certain concentration threshold, Cu can pose toxicity risks to biota. Benthic foraminifera are widely distributed and exhibit characteristics such as high biodiversity, short life cycle, good preservation potential, and high pollutant sensitivity, making them good bioindicators.

Five new triterpenoids isolated from mastic: Structural identification and their anti-inflammatory activity.

Five new oleanane-type triterpenoids were isolated from mastic. Their structures including absolute configurations were determined by extensive spectroscopic methods and single-crystal X-ray crystallographic experiments. Compound 1 is distinguished by its rare furan ring.

Biofluid-Permeable and Erosion-Resistant Wireless Neural-Electronic Interfaces for Neurohomeostasis Modulation.

Neural-electronic interfaces through delivering electroceuticals to lesions and modulating pathological endogenous electrical environments offer exciting opportunities to treat drug-refractory neurological disorders. Such an interface should ideally be compatible with the neural tissue and aggressive biofluid environment. Unfortunately, no interface specifically designed for the biofluid environments is available so far; instead, simply stacking an encapsulation layer on silicon-based substrates makes them susceptible to biofluid leakage, device malfunction, and foreign-body reactions.