An injectable sodium-mangiferin homopolymeric hydrogel accelerated skin full-thickness wound healing in guinea pig model.

In the treatment of joints, mucosa, and full-thickness wounds, traditional implant surgery presents not only inconvenience but also a significant risk of wound infection. Additionally, the pharmaceutical application of mangiferin(MGF) has been severely restricted due to its poor water solubility. In this study, we reported the synthesis and characterization of sodium-mangiferin (MGF-Na(S)) using the salt formation method.

New thermoplastic poly(ester-ether) elastomers with enhanced mechanical properties derived from long-chain dicarboxylic acid for medical device applications.

Recent advances in medical plastics highlight the need for sustainable materials with desirable elastic properties. Traditional polyester elastomers have been used as alternatives to polyvinyl chloride (PVC) due to their biocompatibility and adjustable mechanical properties. However, these materials often lack the necessary stability and toughness for reliable medical applications.

Investigating the common genetic architecture and causality of metabolic disorders with neurodegenerative diseases.

Background: The co-occurrence of metabolic dysfunction and neurodegenerative diseases suggests a genetic link, yet the shared genetic architecture and causality remain unclear. We aimed to comprehensively characterise these genetic relationships.

Methods: We investigated genetic correlations among four neurodegenerative diseases and seven metabolic dysfunctions, followed by bidirectional Mendelian randomisation (MR) to assess potential causal relationships.

Loosening the Solvation Cage in Polysaccharide Polymer Electrolyte for Sustainable Lithium Metal Batteries.

Biomass with naturally ion-conducting segments (e.g., hydroxyl) holds promise for sustainable batteries.

Factors and modification techniques enhancing starch gel structure and their applications in foods:A review.

The formation of starch gel structure results from the gelatinization and retrogradation of starch in aqueous solutions, which plays a crucial role in determining the quality and functional properties of starchy foods. The gelation ability of many native starches is limited and their structure is weak, which restricts their application. Therefore, how to enhance the gel structure of starch is of great significance to food science and industry.

Synthesis and Characterization of Cement Clinker Using Waste Glass and Oyster Shells as Natural Ore Substitutes.

This study investigates the process of synthesizing eco-cement clinker using recycled powdered glass (RPG) and oyster shell residue (OSHL) as primary raw materials. Analysis of the mineral composition of RPG revealed that it primarily consists of silica and contains a high level of alkali metal oxides, while OSHL comprises a high-purity trigonal calcite structure, similar in chemical composition to limestone. Comparative analysis of the synthesized ecological cement and its hydration products showed that, after heat treatment at 1200 °C, the alkali metal content in the H12 sample significantly decreased, thereby meeting the standards for cement raw materials.

Integration of ATAC-Seq and RNA-Seq Reveals VDR-SELENBP1 Axis Promotes Adipogenesis of Porcine Intramuscular Preadipocytes.

Intramuscular fat (IMF) content plays a crucial role in determining pork quality. Recent studies have highlighted transcriptional mechanisms controlling adipogenesis in porcine IMF. However, the changes in chromatin accessibility during adipogenic differentiation are still not well understood.

A Soluble ProDOT-Based Polymer and Its Electrochromic Device with Yellow-to-Green Color Switching Towards Camouflage Application.

Yellow-to-green electrochromic color switching plays a key role in the intelligent adaptive camouflage under the visible light environment in future military camouflage applications. Here, we designed and synthesized a soluble electrochromic conjugated pDPTD polymer, mainly based on perylo[1,12-bcd]thiophene and the novel ProDOT groups. The pDPTD polymer displayed a yellow-to-green electrochromism with large optical contrast and fast switching times.

Research Progress and Outlook of Molecular Dynamics Simulation on Carbon Dioxide Applied for Methane Exploitation from Hydrates.

Research progress of carbon dioxide applied for methane exploitation from hydrates is summarized, with a focus on advances in molecular dynamics simulations and their application in understanding the mechanism of carbon dioxide replacement for hydrate exploitation. The potential of carbon dioxide in enhancing energy recovery efficiency and promoting carbon capture and storage is emphasized. An overview is provided of the advancements made in utilizing carbon dioxide for methane hydrate exploitation, highlighting its significance.

Nuclear Overexpression of SAMHD1 Induces M Phase Stalling in Hepatoma Cells and Suppresses HCC Progression by Interacting with the Cohesin Complex.

Emerging evidence suggests that the sterile alpha-motif (SAM) and histidine-aspartate (HD) domain-containing protein 1 (SAMHD1) is implicated in various cancers, including hepatocellular carcinoma (HCC). However, its precise role in tumor cells and the underlying mechanisms remain unclear. This study aimed to investigate the expression patterns, prognostic values, and functional role of SAMHD1 in HCC progression.

Perspectives on Enhanced Measurement-Based Care Among Healthcare Providers, Adults, Adolescent Patients with Major Depressive Disorder and Pediatric Family Members: A Multicenter Online Investigation.

Objective: Measurement-based care (MBC) is an emerging, objective, and systematic evidence-based practice for monitoring symptom severity and treatment efficacy to assist clinicians in developing individualized treatment strategies for patients with major depressive disorder (MDD). This study aimed to identify the barriers and facilitators of enhanced MBC (eMBC) in the outpatient setting to clarify the eMBC utilization dilemma.

Methods: Between September 2022 and June 2023, we collected the opinions of healthcare providers, adult and adolescent patients, and family members of adolescent patients via online surveys.

RFC4 confers radioresistance of esophagus squamous cell carcinoma through regulating DNA damage response.

Radioresistance in esophageal squamous cell carcinoma (ESCC) is a critical factor leading to treatment failure and recurrence, yet its underlying molecular mechanisms remain unclear. This study aimed to investigate the role of Replication Factor C4 (RFC4) in ESCC radioresistance and to explore the underlying mechanisms. We utilized online bioinformatics tools to analyze the properties, functions, and prognostic significance of RFC4 in ESCC.

Artificial intelligence-driven quantification of antibiotic-resistant Bacteria in food by color-encoded multiplex hydrogel digital LAMP.

Antibiotic-resistant bacteria pose considerable risks to global health, particularly through transmission in the food chain. Herein, we developed the artificial intelligence-driven quantification of antibiotic-resistant bacteria in food using a color-encoded multiplex hydrogel digital loop-mediated isothermal amplification (LAMP) system. The quenching of unincorporated amplification signal reporters (QUASR) was first introduced in multiplex digital LAMP.

Overexpression of miR-133a-3p reduces microglia activation by binding to GCH1, alleviating neuroinflammation and neuropathic pain.

Neuropathic pain is a chronic pain condition that is primarily caused by underlying neurological damage and dysfunction. Recent studies have identified microRNAs (miRNAs) as a key factor in the treatment of neuropathic pain. To explore the effects of miR-133a-3p on neuroinflammation and neuropathic pain via GTP cyclohydrolase (GCH1), and its underlying mechanisms.

Shenling Guchang prescription ameliorates intestinal barrier inflammation in gestational diabetes rats via TLR4/NF-κB pathway.

Gestational diabetes mellitus (GDM) is linked to a greater risk of various maternal and fetal complications, including the possibility of long-term metabolic issues in offspring. Our initial research suggests that the Traditional Chinese Medicine formula, Shenling Guchang prescription (SLGP), may have an impact on the gut microbiota. However, the specific mechanisms through which it affects intestinal barrier inflammation in GDM are still not fully understood.

Spectroscopic characterization of buffer-gas-cooled lead monofluoride molecules in the BΣ(υ' = 0) ← XΠ(υ = 0) transition.

Establishing a nonzero measurement of the electron Electric Dipole Moment (eEDM) has long been a fundamental pursuit in atomic, molecular and optical physics, offering possible insights into new physics beyond the Standard Model. In this regard, lead monofluoride (PbF) has emerged as a potential candidate for measuring eEDM primarily due to its suitable properties such as the strong internal effective electric field, and eEDM-sensitive ground state with large Ω-doubling and small magnetic g factor. In the present work, we realized the production of a buffer-gas-cooled PbF molecular beam and characterized its high-resolution spectroscopy in the BΣ(υ'=0) ← XΠ(υ = 0) transition, including both direct absorption and laser-induced fluorescence spectroscopy.

[Professor 's experience of "regulating both form and spirit" for treating dysmenorrhea].

This article summarizes Professor 's key points and features of acupuncture for primary dysmenorrhea. Professor believes that the location of dysmenorrhea is in the uterus, and the fundamental pathogenesis is the disharmony of both form and spirit. During clinical treatment, he first conducts abdominal palpation, often detecting cord-like nodules around Guilai (ST 29), Huangshu (KI 16), and Zigong (EX-CA 1).

Cone-beam computed tomographic investigation of the association between impacted mandibular third molars and the development of distal caries in adjacent second molars in a Chinese population.

To investigate the association between impacted mandibular third molars (IMTMs) and the prevalence of distal caries in adjacent mandibular second molars (MSMs) in a Chinese population, a retrospective analysis was conducted using cone-beam computed tomography (CBCT) images obtained from routine dental practice for various diagnostic purposes. The impaction patterns of the mandibular third molars were recorded using Winter's classification and Pell and Gregory's classification. The occurrence and severity of distal caries in MSMs were also documented.

Macrophage Dvl2 deficiency promotes NOD1-Driven pyroptosis and exacerbates inflammatory liver injury.

Dishevelled 2 (Dvl2) is a key mediator of the Wingless/Wnt signaling pathway that regulates cell proliferation, migration, and immune function. However, little is known about the role of macrophage Dvl2 in modulating NOD1-mediated pyroptosis and hepatocyte death in oxidative stress-induced inflammatory liver injury. In a mouse model of oxidative stress-induced liver inflammation, mice with myeloid-specific Dvl2 knockout (Dvl2) displayed exacerbated ischemia/reperfusion (IR) stress-induced hepatocellular damage with increased serum ALT levels, oxidative stress, and proinflammatory mediators.

Orthogonally and linearly polarized green emission from a semipolar InGaN based microcavity.

Polarized light has promising applications in biological inspections, displays, and precise measurements. Direct emission of polarized light from a semiconductor device is highly desired in order to reduce the size and energy-consumption of the whole system. In this study, we demonstrate a semipolar GaN-based microcavity light-emitting diode (MCLED) that could simultaneously produce green light with perpendicular and parallel polarizations to the -axis.