sEMG-Based Gesture Recognition Via Multi-Feature Fusion Network.

The sparse surface electromyography-based gesture recognition suffers from the problems of feature information not richness and poor generalization to small sample data. Therefore, a multi-feature fusion network (MFF-Net) model is proposed in this paper. This network incorporates long short-term memory (LSTM) and the attention mechanism into the model, and three sub-networks are constructed for enhancement of features in the time, frequency and spatial domains, respectively.

A self-powered PFC sensing platform via integrating aptamer-modified photoanode and Z-scheme signal amplifying photocathode for microcystin-LR detection.

Background: Microcystin-LR (MC-LR) is a hepatotoxin produced by cyanobacteria, which is biologically toxic, prevalent, and has serious effects on human health. Therefore, it is urgent to develop miniaturized and cost-efficient methods for MC-LR monitoring. Photocatalytic fuel cell (PFC) sensing has already been tipped as a promising approach for facile, on-site detection in environmental mediators.

Comparative transcriptomics of indica and japonica rice roots under heat stress reveals the crucial role of OsMAPK3 in heat response.

Heat stress is one of the most critical environmental factors impacting rice cultivation, driven by the rising global temperatures. Therefore, understanding the differences in molecular mechanisms of heat stress tolerance between rice cultivars, particularly indica and japonica, is crucial for developing heat-tolerant varieties. In this study, high throughput RNA-sequencing technology was utilized to explore the transcriptomic changes in the root tissues of two rice varieties, 93-11 (indica) and ZH11 (japonica) under heat stress and during recovery.

Phage vB_Kpn_HF0522: Isolation, Characterization, and Therapeutic Potential in Combatting K1 Infections.

Purpose: is a globally prevalent pathogen responsible for severe hospital- and community-acquired infections, and presents significant challenges for clinical management. Current therapeutic strategies are no longer able to meet the clinical needs; therefore, there is an urgent need to develop novel therapeutic strategies. This study aimed to evaluate the efficacy of phage therapy in treating bacterial infections.

Integrative multi-omics analysis of radionuclide-induced intestinal injury reveals the radioprotective role of L-citrulline through histone H3-mediated Cxcl3.

Background: The widespread application of nuclear technology has markedly heightened the risk of extensive, uncontrolled exposure to radiation. Nevertheless, in contrast to external irradiation, the biological impacts and countermeasures against internal irradiation from radionuclides remain inadequately characterized.

Methods: Mice were administered yttrium-90 (Y90) carbon microspheres via gavage at different dosages (0-5.

In-Sensor Polarization Convolution Based on Ferroelectric-Reconfigurable Polarization-Sensitive Photodiodes.

In-sensor computing can enhance the imaging system performance by putting part of the computations into the sensor. While substantial advancements have been made in latency, spectral range, and functionalities, the strategy for in-sensor light polarization computing has remained unexplored. Here, it is shown that ferroelectric-reconfigurable polarization-sensitive photodiodes (FPPDs) based on BiFeO nanowire arrays can perform in-sensor computations on polarization information.

Correlations between primary tumour location, biomarkers of inflammation and lung injury, and postoperative pulmonary complications in patients underwent laparoscopic colorectomy: a propensity score matched analysis of 300 patients.

Introduction: The impact of distinct primary colorectal cancer (CRC) sites on lung injury and complications remains largely unexplored, despite the palpable differences in surgical positions, procedures, and the resulting mechanically induced respiratory pressures at each site.

Materials And Methods: This study employed a forwards-looking approach utilising the propensity score matching (PSM) method; 300 patients with pathological CRC after laparoscopic surgery from April 2019 to May 2023 were enrolled. Two categories were bifurcated based on their surgical locations: the rectosigmoid colon (RSC) group and the descending/ascending colon (DAC) group, with a 2:1 ratio.

Peripheral blood immunoinflammatory biomarkers: prospective predictors of postoperative long-term survival and chronic postsurgical pain in breast cancer.

Background: Tumor progression and chronic postsurgical pain (CPSP) in patients with breast cancer are both significantly influenced by inflammation. The associations between immunoinflammatory biomarkers and long-term survival, as well as CPSP, remain ambiguous. This study examined the predictive value of immunoinflammatory biomarkers for both long-term survival and CPSP.

Tumor extracellular vesicle-derived PD-L1 promotes T cell senescence through lipid metabolism reprogramming.

The limited success of cancer immunotherapy has posed challenges in treating patients with cancer. However, promising strides could be made with a deeper understanding of the factors that cause T cell dysfunction within the tumor microenvironment and by developing effective strategies to counteract tumor-induced immune suppression. Here, we report that tumor-derived extracellular vesicles (tEVs) can induce senescence and suppression in T cells.

Poor Glycemic Control in Carbapenem-Resistant Infections: Impact on Epidemiological Features, Mortality Risks, and Polymyxin Resistance.

Purpose: This study aims to investigate the relationship between glycemic control and epidemiological characteristics of patients infected with carbapenem-resistant (CRKP), to identify mortality risk factors associated with CRKP infection, and to evaluate the impact of glucose on the resistance of CRKP to polymyxin and serum killing.

Patients And Methods: Clinical cases of 218 patients infected with CRKP were collected from a large tertiary public hospital in Anhui Province. We analyzed whether the glycemic control impacts the clinical and laboratory manifestations of infected patients.

Driving forces of agricultural ammonia emissions in semi-arid areas of China: A spatial econometric approach.

Ammonia emissions contribute to PM formation, posing significant threats to public health, including respiratory and cardiovascular diseases, and causing various ecological issues, such as soil and water acidification. This study investigates ammonia emissions in the semi-arid region of central Gansu Province, China, by establishing a county-level agricultural ammonia emission inventory for 2014-2020 using the emission factor method. A spatial econometric model, integrated with the STIRPAT (Stochastic Impacts by Regression on Population, Affluence, and Technology) model, is employed to identify key drivers of emissions.

Lamp2 Deficiency Enhances Susceptibility to Oxidative Stress-Induced RPE Degeneration.

Purpose: Autophagy and lysosomal degradation are vital processes that protect cells from oxidative stress. This study investigated the role of lysosome-associated membrane protein 2 (Lamp2), a lysosomal protein essential for autophagosome maturation and lysosome biogenesis, in maintaining retinal health under oxidative stress.

Methods: To induce oxidative stress, young Lamp2 knockout (KO) and wild-type mice received an intravenous injection of a low dose (10 mg/kg) of sodium iodate (NaIO3).

Differentiation of genome-wide DNA methylation between japonica and indica rice.

Rice (Oryza sativa L.) subspecies japonica and indica show distinct morphological and genetic differentiation. However, the differences in the genome-wide DNA methylation and its effects on gene expression and metabolic levels between japonica and indica rice remain unclear.

Dissecting the Binding Affinity of Anti-SARS-CoV-2 Compounds to Human Transmembrane Protease, Serine 2: A Computational Study.

The human transmembrane protease, serine 2 (TMPRSS2), essential for SARS-CoV-2 entry, is a key antiviral target. Here, we computationally profiled the TMPRSS2-binding affinities of 15 antiviral compounds. Molecular dynamics (MD) simulations for the docked complexes revealed that three compounds exited the substrate-binding cavity (SBC), suggesting noncompetitive inhibition.

Optogenetics in medicine: innovations and therapeutic applications.

Optogenetics, an innovative approach integrating photonics and genetic engineering, enables precise control over molecular and cellular processes, opening up exciting new opportunities for precision-guided medicine. In this review, we highlight recent advances in optogenetic tools and their applications across a range of medical conditions, including vision restoration in retinitis pigmentosa via light-activated ion channels, precise immune response modulation in cancer immunotherapy, and blood glucose management in diabetes through controllable drug release. Optogenetics also plays a critical role in bioelectronic medicine, enabling seamless communication between electronic systems and biological tissues to enhance therapeutic precision.

Diabetic foot ulcer related pain and its impact on health-related quality of life.

Background: Diabetic foot ulcers (DFUs) are a prevalent complication of diabetes. Individuals with DFUs can experience wound-related pain, which could be nociceptive and/or neuropathic in origin, which adversely affects health-related quality of life (HRQoL).

Aim: To determine the prevalence and characteristics of DFU-related pain and its impact on HRQoL in community-dwelling individuals with active DFUs.

Comprehensive single-cell atlas of colorectal neuroendocrine tumors with liver metastases: unraveling tumor microenvironment heterogeneity between primary lesions and metastases.

Background: Colorectal neuroendocrine tumors with liver metastases (CRNELM) are associated with a poorer prognosis compared to their nonmetastatic counterparts. A comprehensive understanding of the tumor microenvironment (TME) heterogeneity between primary lesions (PL) and liver metastases (LM) could provide crucial insights for enhancing clinical management strategies for these patients.

Methods: We utilized single-cell RNA sequencing to analyze fresh tissue samples from CRNELM patients, aiming to elucidate the variations in TME between PL and LM.

The role of lipid metabolism in cognitive impairment.

Alzheimer's disease (AD), diabetic cognitive impairment (DCI), and vascular dementia (VD) are considered the most common causes of severe cognitive impairment in clinical practice. Numerous factors can influence their progression, and many studies have recently revealed that metabolic disorders play crucial roles in the progression of cognitive impairment. Mounting evidence indicate that the regulation of lipid metabolism is a major factor in maintaining brain homeostasis.

SRC enhanced cisplatin resistance in bladder cancer by reprogramming glycolysis and pentose phosphate pathway.

The development of cisplatin resistance often results in a grim prognosis in advanced or recurrent bladder cancer. However, effective treatment strategies for cisplatin resistance have not been well established. Herein, we found that overactivation of SRC is associated with cisplatin-resistance.

Structure-Reactivity Relationship of Zeolite-Confined Rh Catalysts for Hydroformylation of Linear α-Olefins.

Substituting the molecular metal complexes used in the industrial olefin hydroformylation process is of great significance in fundamental research and practical application. One of the major difficulties in replacing the classic molecular metal catalysts with supported metal catalysts is the low chemoselectivity and regioselectivity of the supported metal catalysts because of the lack of a well-defined coordination environment of the metal active sites. In this work, we have systematically studied the influences of key factors (crystallinity, alkali promoters, etc.

Identification of therapeutic target genes for age-related hearing loss through systematic genome-wide mendelian randomization of druggable genes.

Background: Age-related hearing loss (ARHL) is a common sensory disorder with significant public health implications. However, few effective treatment options are available. Mendelian randomization (MR) has been used to repurpose existing drugs and identify new therapeutic targets.

Investigating steeply inclined abandoned mines for unlocking the secrets of water level recovery.

With the growing emphasis on environmental protection, many coal mines in northern China were closed. However, the cessation of pumping operations in those closed mines has caused a rise in groundwater levels, giving rise to various safety and environmental concerns. Understanding the patterns of water level recovery is vital for effectively managing abandoned mine sites and ensuring the uninterrupted production of adjacent coal mines.