Publications by authors named "Tao Sha"

Objective: Understanding the impact of sociocultural tendencies on the personality development of adolescents represents a critical theoretical and practical issue in the field of adolescent development. In the context of China's collectivist culture, the developmental trajectories of and the interaction between sensation seeking and collectivism among adolescents remain largely unknown.

Method: This study examined the heterogeneity of the joint growth patterns of sensation seeking and collectivism and their interactions across distinct latent trajectory classes.

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Objectives: Entrectinib and crizotinib are the only ROS proto-oncogene 1 receptor (ROS1) tyrosine kinase inhibitors available for most Asian patients. Their efficacy has neither been compared directly in clinical trials in patients with ROS1-positive non-small cell lung cancer (NSCLC), nor indirectly in Asian populations. Thus, we aimed to provide comparative evidence of the efficacy and safety of entrectinib and crizotinib for Asian patients with advanced or metastatic ROS1-positive NSCLC.

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Article Synopsis
  • The study investigates the hypothalamus's development during childhood and adolescence and how emotional and behavioral issues can affect this process, addressing gaps in current understanding.
  • Researchers analyzed data from 702 children, using MRI scans and behavioral assessments to identify how different regions of the hypothalamus grow and change over time.
  • Results show that while some regions decline in volume, others increase, and emotional problems can speed up certain growth patterns, suggesting a connection between mental health and hypothalamic development.
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Brain development is characterized by an increase in structural and functional segregation, which supports the specialization of cognitive processes within the context of network neuroscience. In this study, we investigated age-related changes in morphological segregation using individual Regional Radiomics Similarity Networks (R2SNs) constructed with a longitudinal dataset of 494 T1-weighted MR scans from 309 typically developing children aged 6.2 to 13 years at baseline.

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Article Synopsis
  • Scientists studied how different parts of the brain work together as kids grow up, looking at over 300 kids aged 6 to 14.
  • They found that some brain areas belong to multiple groups (or modules) that change in strength as children age, and this depends on the brain's structure.
  • The results showed that activities in certain brain areas were more flexible in joining different groups while others stayed more fixed, helping to explain how kids' brains get better at thinking and learning over time.
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Importance: Small, geographically limited studies report that people with intellectual and developmental disabilities (IDD) have increased risk for serious pregnancy-related and birth-related challenges, including preeclampsia, preterm birth, and increased anxiety and depression, than their peers. United States-based population-level data among people with IDD are lacking.

Objectives: To identify perinatal and postpartum outcomes among a national, longitudinal sample of people with IDD enrolled in public health insurance, compare subgroups of people with IDD, and compare outcomes among people with IDD with those of peers without IDD.

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NAD-dependent deacetylase Sirt2 is involved in mammalian metabolic activities, matching energy demand with energy production and expenditure, and is relevant to a variety of metabolic diseases. Here, we constructed Sirt2 knockout and adeno-associated virus overexpression mice and found that deletion of hepatic Sirt2 accelerated primary obesity and insulin resistance in mice with concomitant hepatic metabolic dysfunction. However, the key targets of Sirt2 are unknown.

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A novel "windmill" three-channel light-emitting diode induced fluorescence detector (LED-IF) was proposed to maximize the excitation efficiency and fluorescence collection efficiency. Compared with the typical collinear arrangement, the fluorescence intensity of the three channels was increased by 7.85, 3.

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Background: The trajectory of attention-deficit hyperactivity disorder (ADHD) symptoms in children and adolescents, encompassing descending, stable, and ascending patterns, delineates their ADHD status as remission, persistence or late onset. However, the neural and genetic underpinnings governing the trajectory of ADHD remain inadequately elucidated.

Methods: In this study, we employed neuroimaging techniques, behavioral assessments, and genetic analyses on a cohort of 487 children aged 6-15 from the Children School Functions and Brain Development project at baseline and two follow-up tests for 1 year each (interval 1: 1.

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Background: The right middle frontal gyrus (MFG) has been proposed as a convergence site for the dorsal attention network (DAN) and ventral attention network (VAN), regulating both networks and enabling flexible modulation of attention. However, it is unclear whether the connections between the right MFG and these networks can predict changes in attention-deficit/hyperactivity disorder (ADHD) symptoms.

Methods: This study used data from the Children School Functions and Brain Development project (N = 713, 56.

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Educators have recently garnered significant focus for the crucial role they play, particularly concerning their emotions. These emotions have the potential to either boost their progress in their profession or hinder their progress, like burnout which may trigger or intensify poor mental health and quit the job. Burnout arises from the intermittent occurrence of emotional distress among English as a foreign language (EFL) educators as they fulfill their professional duties.

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The substantia nigra (SN), subthalamic nucleus (STN), and red nucleus (RN) have been widely studied as important biomarkers of degenerative diseases. However, how they develop in childhood and adolescence and are affected by emotional behavior has not been studied thus far. This population-based longitudinal cohort study used data from a representative sample followed two to five times.

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From childhood to adulthood, the human brain develops highly specialized yet interacting neural modules that give rise to nuanced attention and other cognitive functions. Each module can specialize over development to support specific functions, yet also coexist in multiple neurobiological modes to support distinct processes. Advances in cognitive neuroscience have conceptualized human attention as a set of cognitive processes anchored in highly specialized yet interacting neural systems.

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Risk-taking often occurs in childhood as a compex outcome influenced by individual, family, and social factors. The ability to govern risky decision-making in a balanced manner is a hallmark of the integrity of cognitive and affective development from childhood to adulthood. The Triadic Neural Systems Model posits that the nuanced coordination of motivational approach, avoidance and prefrontal control systems is crucial to regulate adaptive risk-taking and related behaviors.

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Article Synopsis
  • Cortical thinning occurs as the brain develops during childhood and adolescence, especially in areas like the lateral frontal and parietal regions.
  • This thinning is influenced by the brain's white matter network, which affects how different brain regions connect and communicate.
  • The study reveals that these changes have a genetic basis linked to the brain's structural development, and the results are consistent across different datasets.
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Children with autism frequently present with complex mental health diagnoses and psychotropic medications are often a component of comprehensive biopsychosocial treatment plans for these conditions. The purpose of this study is to provide rates and patterns of psychotropic medication use, and predictors thereof, in children and youth with autism enrolled in Medicaid across the US. This study examined national Medicaid claims from 2008 to 2016 of all children and youth with autism ages 0-21 years enrolled in Medicaid.

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From childhood to adolescence, the spatiotemporal development pattern of the human brain white matter connectome and its underlying transcriptomic and cellular mechanisms remain largely unknown. With a longitudinal diffusion MRI cohort of 604 participants, we map the developmental trajectory of the white matter connectome from global to regional levels and identify that most brain network properties followed a linear developmental trajectory. Importantly, connectome-transcriptomic analysis reveals that the spatial development pattern of white matter connectome is potentially regulated by the transcriptomic architecture, with positively correlated genes involve in ion transport- and development-related pathways expressed in excitatory and inhibitory neurons, and negatively correlated genes enriches in synapse- and development-related pathways expressed in astrocytes, inhibitory neurons and microglia.

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Article Synopsis
  • The study investigates how the NR4A1-MDM2-P53 signaling pathway contributes to ferroptosis in renal tubular cells, particularly during renal ischemia-reperfusion injury (RIRI).
  • By analyzing gene expression data from the GEO database and constructing an in vitro model with mouse kidney cells, researchers found that NR4A1 plays a key role in inducing ferroptosis through its interaction with MDM2 and P53.
  • The findings suggest that targeting NR4A1 could provide a new therapeutic strategy to mitigate kidney damage from RIRI by preventing ferroptosis and reducing oxidative stress.
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Both reading difficulties (RD) and mathematics difficulties (MD) are common neurodevelopmental disorders. The co-occurrence of RD and MD, known as comorbid RDMD, is estimated to range between 21% and 45% of children with learning disabilities. Deficits in working memory have been reported in both RD and MD groups, as well as among comorbid RDMD.

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This study examined the longitudinal associations of various executive function components with subsequent psychiatric problems in Chinese school-age children. Data from 1,639 children (44.36% girls) ages 6-13 years were drawn from the Children School Functions and Brain Development project.

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The lifespan growth of the functional connectome remains unknown. Here, we assemble task-free functional and structural magnetic resonance imaging data from 33,250 individuals aged 32 postmenstrual weeks to 80 years from 132 global sites. We report critical inflection points in the nonlinear growth curves of the global mean and variance of the connectome, peaking in the late fourth and late third decades of life, respectively.

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Point-of-care testing (POCT) of morphine (MOP) without invasion of privacy is of critical importance for law-enforcement departments to realize on-site rapid screening. In this study, ultrasensitive and non-invasive screening of MOP residues in the fingerprint sweat was easily realized by stepwise Au decoration-assisted double signal amplification and antibody-saving strategies on lateral flow strip (LFS). The construction of LFS was not intrinsically changed compared with traditional LFS except the labeling material on conjugation pad for enhanced signal reporting.

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