Environmental life cycle assessment of large-scale coal mining with annual output of more than one million tonnes.

Coal occupies an absolute advantage in the primary energy structure of China. However, the production of coal poses a serious threat to the ecological environment and human health. In order to quantify the environmental impact of coal mining, this study used the life cycle assessment (LCA) method to analyse the life cycle of coal mining from the cradle-to-gate.

The diagnostic effect of integrated visual and auditory continuous performance and event-related potentials in ADHD.

Objective: The development of objective assessment tools for attention deficit hyperactivity disorder (ADHD) has become a hot research topic. The aim was to explore the value of the P300 wave and integrated visual and auditory continuous performance test (IVA-CPT) in diagnosing ADHD.

Methods: We enrolled 30 patients with ADHD and 30 age-matched healthy volunteers in a prospective study to evaluate differences in IVA-CPT and P300 indexes using student t test.

Preoperative methionine restriction induces perivascular adipose tissue browning and improves vein graft remodeling in male mice.

Short-term preoperative methionine restriction (MetR) is a promising translatable strategy to mitigate surgical injury response. However, its application to improve post-interventional vascular remodeling remains underexplored. Here we find that MetR protects from arterial intimal hyperplasia in a focal stenosis model and pathologic vascular remodeling following vein graft surgery in male mice.

Resting natural killer cells promote the progress of colon cancer liver metastasis by elevating tumor-derived stem cell factor.

The abundance and biological contribution of natural killer (NK) cells in cancer are controversial. Here, we aim to uncover clinical relevance and cellular roles of NK cells in colon cancer liver metastasis (CCLM). Here, we integrated single-cell RNA-sequencing, spatial transcriptomics (ST), and bulk RNA-sequencing datasets to investigate NK cells' biological properties and functions in the microenvironment of primary and liver metastatic tumors.

A General DNA-Like Hybrid Symbiosis Framework: An EEG Cognitive Recognition Method.

In electroencephalogram (EEG) cognitive recognition research, the combined use of artificial neural networks (ANNs) and spiking neural networks (SNNs) plays an important role to realize different categories of recognition tasks. However, most of the existing studies focus on the unidirectional interaction between an ANN and a SNN, which may be overly dependent on the performance of ANNs or SNNs. Inspired by the symbiosis phenomenon in nature, in this study, we propose a general DNA-like Hybrid Symbiosis (DNA-HS) framework, which enables mutual learning between the ANN and the SNN generated by this ANN through parametric genetic algorithm and bidirectional interaction mechanism to enhance the optimization ability of the model parameters, resulting in a significant improvement of the performance of the DNA-HS framework in all aspects.

Associating factors of cognitive frailty among older people with chronic heart failure: Based on LASSO-logistic regression.

Aim: To analyse factors associated with cognitive frailty among older chronic heart failure patients in China.

Design: A cross-sectional design.

Methods: Between August 2021 and November 2022, a total of 421 chronic heart failure patients (age ≥60 years) were randomly selected from the cardiology department of the affiliated hospital of Zunyi Medical University.

Life cycle assessment of electrolytic manganese metal production.

Manganese is an indispensable metal widely used in various fields. China ranks as the fourth-largest producer of manganese ore and the largest producer of electrolytic manganese metal (EMM). However, EMM production is linked to high energy consumption and pollution.

New HCC Subtypes Based on CD8 Tex-Related lncRNA Signature Could Predict Prognosis, Immunological and Drug Sensitivity Characteristics of Hepatocellular Carcinoma.

Purpose: Hepatocellular carcinoma has become one of the severe diseases threatening human health. T cell exhaustion is deemed as a reason for immunotherapy resistance. However, little is known about the roles of CD8 Tex-related lncRNAs in HCC.

Advancements in Biosensors for Point-of-Care Testing of Nucleic Acid.

Rapid, low-cost and high-specific diagnosis based on nucleic acid detection is pivotal in both detecting and controlling various infectious diseases, effectively curbing their spread. Moreover, the analysis of circulating DNA in whole blood has emerged as a promising noninvasive strategy for cancer diagnosis and monitoring. Although traditional nucleic acid detection methods are reliable, their time-consuming and intricate processes restrict their application in rapid field assays.

Positive feedback regulation between glycolysis and histone lactylation drives oncogenesis in pancreatic ductal adenocarcinoma.

Background: Metabolic reprogramming and epigenetic alterations contribute to the aggressiveness of pancreatic ductal adenocarcinoma (PDAC). Lactate-dependent histone modification is a new type of histone mark, which links glycolysis metabolite to the epigenetic process of lactylation. However, the role of histone lactylation in PDAC remains unclear.

Association between cheese and fish consumption and the occurrence of depression based on European population: mediating role of metabolites.

Background: The consumption of cheese and fish has been linked to the onset of depression. However, the connection between consuming cheese, consuming fish, experiencing depression, and the pathways that mediate this relationship remains unclear. The purpose of this research was to investigate the potential association between the consumption of cheese and fish and the occurrence of depression.

Evaluating the efficacy and safety of Alzheimer's disease drugs: A meta-analysis and systematic review.

Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Dementia severity was assessed mainly through cognitive function, psychobehavioral symptoms, and daily living ability. Currently, there are not many drugs that can be selected to treat mild to moderate AD, and the value of drugs remains controversial.

Pregnancy and the disease recurrence of patients previously treated for differentiated thyroid cancer: A systematic review and meta analysis.

Background: Differentiated thyroid cancer (DTC) is commonly diagnosed in women of child-bearing age, but whether pregnancy influences the prognosis of DTC remains controversial. This study aimed to summarize existing evidence regarding the association of pregnancy with recurrence risk in patients previously treated for DTC.

Methods: We searched PubMed, Embase, Web of Science, Cochrane, and Scopus based on the prespecified protocol registered at PROSPERO (CRD42022367896).

Design and Validation of a Short Novel Estradiol Aptamer and Exploration of Its Application in Sensor Technology.

The specific and sensitive detection of 17β-estradiol (E2) is critical for diagnosing and treating numerous diseases, and aptamers have emerged as promising recognition probes for developing detection platforms. However, traditional long-sequence E2 aptamers have demonstrated limited clinical performance due to redundant structures that can affect their stability and recognition ability. There is thus an urgent need to further optimize the structure of the aptamer to build an effective detection platform for E2.

Life cycle assessment of coal mines of diverse scales over time in China.

Coal mining has important detrimental effects on the environment and human health. By the end of 2022, China mined more than 4 billion tons of raw coal, and coal mining contributed to adverse environmental impacts. The objective of this work is to evaluate the environmental impacts emanated from coal mines in different periods (construction period, production period and closing period) and to find the relationship between coal mine scale and ecological impacts.

Effectiveness and safety of umbilical cord milking in premature infants: A randomized controlled trial.

Introduction: Both UCM and DCC are used to treat preterm infants, but there is no uniform standard for the length of UCM. The aim of this work was to explore the effectiveness and safety of different umbilical cord milking (UCM) lengths versus delayed cord clamping (DCC).

Methods: We enrolled premature infants from the Affiliated Hospital of Zunyi Medical University between September 2019 and October 2020 with random allocation (1:1:1:1) to the UCM 10 cm, UCM 20 cm, UCM 30 cm, and DCC groups.

Short-term Pre-operative Methionine Restriction Induces Browning of Perivascular Adipose Tissue and Improves Vein Graft Remodeling in Mice.

Short-term preoperative methionine restriction (MetR) shows promise as a translatable strategy to modulate the body's response to surgical injury. Its application, however, to improve post-interventional vascular remodeling remains underexplored. Here, we find that MetR protects from arterial intimal hyperplasia in a focal stenosis model and adverse vascular remodeling after vein graft surgery.

Land use carbon emissions estimation and carbon emissions control strategy effect scenario simulation in Zhejiang province.

Carbon emission control is an important aspect of regional sustainable development. However, there are few studies on predicting the impact of different socio-economic development strategies on carbon emissions under the premise of established government policy objectives, and then evaluating the degree of achievement of policy objectives. In order to research the effect of social and economic development strategies on carbon emissions, remote sensing land use data of Zhejiang Province from 2000 to 2020 were utilized in this paper to quantify carbon emissions, combined with Kaya identity and LMDI decomposition method, and multi-scenario carbon emissions simulation and prediction were carried out under the STIRPAT model framework.

A chromosome-level genome assembly for the astaxanthin-producing microalga Haematococcus pluvialis.

The green microalga Haematococcus pluvialis can synthesize high amounts of astaxanthin, which is a valuable antioxidant that has been utilized in human health, cosmetics, and aquaculture. To illustrate detailed molecular clues to astaxanthin yield, we performed PacBio HIFI along with Hi-C sequencing to construct an improved chromosome-level haplotypic genome assembly with 32 chromosomes and a genome size of 316.0 Mb.

Platinum Black/Gold Nanoparticles/Polyaniline Modified Electrochemical Microneedle Sensors for Continuous In Vivo Monitoring of pH Value.

Continuous in vivo monitoring (CIVM) of pH value is essential for personalized medicine, as many diseases are closely related to acid-base imbalances. However, conventional pH meters are limited in their ability to perform CIVM due to excessive blood consumption, large device volume, frequent calibration, and inadequate real-time monitoring. There is thus an urgent need for a portable method for CIVM of pH value.

The effect of oropharyngeal colostrum administration on the clinical outcomes of premature infants: A meta-analysis.

Background: Preterm complications are now the second leading cause of death in children under five years of age. Colostrum is essential to prevent infection and promote maturation in preterm infants. Guidelines recommend that preterm infants be fed colostrum by the oral and pharyngeal routes as early as possible after birth to provide immune protection; however, due to disease and an uncoordinated sucking and swallowing function, it is challenging to provide colostrum through the oropharyngeal route, which limits the immune protection it provides.

Reduced Graphene Oxide and Gold Nanoparticles-Modified Electrochemical Aptasensor for Highly Sensitive Detection of Doxorubicin.

Doxorubicin (DOX) is the most clinically important antibiotic in cancer treatment, but its severe cardiotoxicity and other side effects limit its clinical use. Therefore, monitoring DOX concentrations during therapy is essential to improve efficacy and reduce adverse effects. Here, we fabricated a sensitive electrochemical aptasensor for DOX detection.

Natural products regulate mitochondrial function in cognitive dysfunction-A scoping review.

Medicines from natural products can not only treat neurodegenerative diseases but also improve the cognitive dysfunction caused by treatments with western medicines. This study reviews the literature related to the regulation of mitochondrial participation in cognitive function by natural products. In this study, we focused on English articles in PubMed, Web of Science, and Google Scholar, from 15 October 2017, to 15 October 2022.