Oncological outcomes of surgical management for T2N0M0 glottic laryngeal squamous cell carcinoma.

Objectives: The research aimed to evaluate the clinical treatment outcomes of T2N0M0 glottic laryngeal squamous cell carcinoma (LSCC) patients who underwent laryngectomy.

Methods: Retrospective review of 533 T2N0M0 glottic LSCC patients.

Results: Five-year cancer-specific survival (CSS) rate was 90.

Correlation of visual acuity changes and optical coherence tomography imaging in patients with central retinal artery occlusion post-arterial thrombolysis.

This retrospective study investigates the correlation between visual acuity changes and structural modifications observed through optical coherence tomography (OCT) in patients with central retinal artery occlusion (CRAO) treated with urokinase. Conducted at the Neuro-Ophthalmology Center of Xi'an People's Hospital from January 2022 to May 2023, the study included 217 CRAO patients (217 eyes), comprising 157 males and 60 females, aged 18 to 83 years (mean age: 57.8 ± 13.

Over-expression of AeWRKY2 promotes oleanolic acid and hederagenin accumulation in Aralia elata.

Oleanolic acid (OA) and hederagenin from Aralia elata have important medicinal value due to their anti-cancer and anti-inflammatory activities. Transcription factors (TFs) can affect the production of active substances by regulating the expression of genes in metabolic pathways. In this study, a transcription factor AeWRKY2 was cloned and overexpressed in A.

Self-Healing Hydrogel Dressing with Solubilized Flavonoids for Whole Layer Regeneration of Diabetic Wound.

Hydrogels are soft, tissue-like materials that have great potential as wound dressings. However, most hydrogels are unsatisfactory in achieving whole-layer regeneration of diabetic wounds due to the complex pathological microenvironment and irregular wound shapes. Here, a glucose-responsive and self-adaptive phenylboronic acid (PBA) hydrogel solubilized strong antioxidant flavonoids (Gel-Flavonoids) is developed via dynamic borate bonds.

Real-World Insights Into cN3 Larynx and Hypopharynx Cancer: Treatment Modalities, Long-Term Outcomes, and Prognostic Factors.

Objectives: cN3 larynx and hypopharynx cancer is rare with a poor prognosis. This study evaluates treatment approaches, effectiveness, and prognosis for these patients in real-world settings. It aims to offer targeted and practical clinical guidance to enhance their treatment results and quality of life.

Atomic Symbiotic-Catalyst for Low-Temperature Zinc-Air Battery.

Atomic-level designed electrocatalysts, including single-/dual-atom catalysts, have attracted extensive interests due to their maximized atom utilization efficiency and increased activity. Herein, a new electrocatalyst system termed as "atomic symbiotic-catalyst", that marries the advantages of typical single-/dual-atom catalysts while addressing their respective weaknesses, was proposed. In atomic symbiotic-catalyst, single-atom MN and local carbon defects formed under a specific thermodynamic condition, act synergistically to achieve high electrocatalytic activity and battery efficiency.

An infrared dataset for partially occluded person detection in complex environment for search and rescue.

The combination of unmanned aerial vehicles (UAVs) and deep learning has potential applicability in various complex search and rescue scenes. However, due to the presence of environmental occlusions such as trees, the performance of UAVs mounted with different optical payloads in detecting missing persons is poor. To the best of our knowledge, currently available non-occluded human target datasets are insufficient to address the challenges of automatic recognition for partially occluded human targets.

[Hydrochemical Characteristics and Mechanism Analysis of Shallow Groundwater in Beijing Plain Area].

Groundwater is an important resource for alleviating global water scarcity. Therefore, understanding its hydrochemical characteristics and mechanisms is of great significance for groundwater management. A total of 210 groundwater samples from shallow monitoring wells in the plain area of Beijing were collected in this study.

Food effects and pharmacokinetic evaluation of oral single-dose prednisone acetate and prednisolone in healthy Chinese subjects.

Background: To assess the food effects and pharmacokinetic profile of oral prednisone (test preparation,5 mg) and prednisolone tablets (reference preparation,5 mg) using a randomized, two-period, two crossover, single-dose, fast and fed trial in 48 (24 in fast, 24 in fed) healthy Chinese adult subjects.

Materials And Methods: In the trial, the plasma concentrations were determined at different time points up to 24 h and the pharmacokinetic parameters were analyzed according to the concentration data by non-compartmental analysis using WinNonlin software. All laboratory parameters, vital signs and adverse events (AEs) were monitored and recorded under the supervision of the clinicians throughout the whole process of the study.

Synthesis and Performance of Epoxy-Terminated Hyperbranched Polymers Based on Epoxidized Soybean Oil.

Epoxy-terminated hyperbranched polymers (EHBPs) are a class of macromolecular polymers with a hyperbranched structure containing epoxy groups. They possess characteristics such as low viscosity, high functionality, and thermal stability, which endow them with broad application potential in materials science and chemical engineering. This study uses epoxidized soybean oil (ESO) as the raw material, which undergoes ring-opening reactions with glycerol and is esterified with 2,2-bis(hydroxymethyl)propionic acid (DMPA) to obtain epoxy soybean oil polyol (EGD) with a high hydroxyl value.

Discovery, structural characteristics and evolutionary analyses of functional domains in Acinetobacter baumannii phage tail fiber/spike proteins.

Background: The global rise in multidrug-resistant Acinetobacter baumannii infections poses a significant healthcare challenge. Bacteriophage offer a promising alternative to antibiotics for treating A. baumannii infections.

CD8 T cells in patients with hypopharyngeal squamous cell carcinoma are susceptible to radiation-induced damage.

Radiotherapy (RT) is a commonly used clinical management for hypopharyngeal squamous cell carcinoma (HPSCC), which represents the most unfavorable prognosis among all subtypes of head and neck squamous cell carcinoma. However, radiation may cause lymphopenia, a significantly adverse event with detrimental prognostic implications for patients. While CD8 T cells are vital in tumor immunity, the specific effects of RT on CD8 T cells as well as the underlying mechanisms have not been clearly elucidated.

Circular RNAs in cancer.

Circular RNA (circRNA), a subtype of noncoding RNA, has emerged as a significant focus in RNA research due to its distinctive covalently closed loop structure. CircRNAs play pivotal roles in diverse physiological and pathological processes, functioning through mechanisms such as miRNAs or proteins sponging, regulation of splicing and gene expression, and serving as translation templates, particularly in the context of various cancers. The hallmarks of cancer comprise functional capabilities acquired during carcinogenesis and tumor progression, providing a conceptual framework that elucidates the nature of the malignant transformation.

Graphitized Layers Encapsulated Carbon Nanofibers as Li-Free Anode for Hybrid Li-Ion/Metal Batteries.

Hard carbon, the Li-free anode for hybrid Li-ion/metal batteries (LIB/LMBs), has great potential for enhancing fast charging capability, energy density, and battery lifespan. However, low initial Coulombic efficiency (ICE) and Li dendrite growth are crucial factors constraining its development. In this work, graphitized layers encapsulated carbon nanofibers (G-CF) are fabricated via Joule heating within 10 s.

Thiophene engineering of near-infrared D-π-A nano-photosensitizers for enhanced multiple phototheranostics and inhibition of tumor metastasis.

Phototherapy including photothermal therapy (PTT) and photodynamic therapy (PDT) is widely used for cancer treatment because of its non-invasiveness, spatiotemporal controllability, and low side effects. However, the PTT and PDT capabilities of photosensitizers (PSs) compete so it's still a crucial challenge to simultaneously enhance the PDT and PTT capabilities of PSs. In this work, donor-π-acceptor (D-π-A)-based boron dipyrromethene (BODIPY) dyes were developed via molecular engineering and applied for enhanced phototherapy of triple-negative breast cancer.

Metabolomic and Transcriptomic Analyses of Flavonoid Biosynthesis in Different Colors of Soybean Seed Coats.

Soybean has outstanding nutritional and medicinal value because of its abundant protein, oil, and flavonoid contents. This crop has rich seed coat colors, such as yellow, green, black, brown, and red, as well as bicolor variants. However, there are limited reports on the synthesis of flavonoids in the soybean seed coats of different colors.

Impact of different staging methods of lymph nodes metastases on prognosis in advanced hypopharyngeal squamous cell carcinoma.

Background: Lymph node ratio (LNR), log odds of positive lymph nodes (LODDS), and the number of postoperative lymph node staging (pN) are prognostic indicators of various cancers. However, the prognostic values of these indicators remain unclear in hypopharyngeal squamous cell carcinoma (HPSCC). This study's primary objective was to investigate the predictive value of LNR, LODDS, and pN for advanced HPSCC, and the secondary objective was to compare which of the values had the best predictive value for advanced HPSCC.

ARSOD-YOLO: Enhancing Small Target Detection for Remote Sensing Images.

Remote sensing images play a vital role in domains including environmental monitoring, agriculture, and autonomous driving. However, the detection of targets in remote sensing images remains a challenging task. This study introduces innovative methods to enhance feature extraction, feature fusion, and model optimization.

Application of CT images for reconstruction of adigital model of the sacral nerve canal.

Objectives: To construct a three-dimensional visualized model of the sacral nerve canal, and understand its structure and angles.

Methods: This was a retrospective study including 20 patients undergoing computerized tomography (CT) scanning of the sacrum. Consecutive CT images in Dicom format were directly imported into Mimics software.

Transferrin ameliorates retinal degeneration by mediating the dimerization of all-trans-retinal.

High levels of all-trans-retinal (atRAL) in the retina is considered to be responsible for the development of autosomal recessive Stargardt's disease (STGD1) and dry age-related macular degeneration (dAMD). Two bisretinoids, all-trans-retinal dimer (atRAL-dimer) and N-retinyl-N-retinylidene ethanolamine (A2E), form from the dimerization of atRAL in the retina but they possess much lower toxicity and phototoxicity toward retinal pigment epithelium (RPE) cells than atRAL. Here, we introduced a novel function of transferrin (TRF) in mediating the conversion of atRAL into atRAL-dimer and A2E, which effectively protected the retina from damage by atRAL and prevented retinal function decline in mice, and rescued atRAL-loaded RPE cells.

Study on the influence of soil properties on fluorescence intensity of polycyclic aromatic hydrocarbons.

The properties of soil matrix have an impact on the fluorescence intensity of polycyclic aromatic hydrocarbons (PAHs), which restricts the application of fluorescence spectral technology in detecting PAHs in soil. The present study explored the mechanism of the influence of soil matrix properties on the fluorescence intensity of PAHs from the perspective of specific surface area (SSA). A three-factor three-level experimental design was adopted for investigating the relationship between soil matrix properties, PAH fluorescence intensity, and soil SSA.

Danggui Liuhuang Decoction ameliorates endothelial dysfunction by inhibiting the JAK2/STAT3 mediated inflammation.

Ethnopharmacological Relevance: Vascular endothelial dysfunction (VED) is recognized as a key triggering diabetic vascular complications. Danggui Liuhuang Decoction (DGLHD) has shown potential in mitigating these complications. However, the clinical efficacy of DGLHD in enhancing endothelial function, as well as the molecular mechanisms underlying its alleviation of Type 2 Diabetes-Related Vascular Endothelial Dysfunction (T2DM-VED), remains insufficiently understood.

The mechanism of carbon and nitrogen metabolism under low temperature and low light stress after heading in late indica rice.

Double-season late indica rice frequently experiences low temperature accompanying with low light stress during the grain filling stage in southern China, which alters the carbon and nitrogen metabolism of the rice grains, thereby impacting both grain yield and quality. However, the physiological mechanism is still unclear. A pot experiment using two late indica rice cultivars (high-quality and common-quality rice cultivars) was conducted under control (CK), low temperature (LT) and low temperature and light (LT + LL) to investigate the grain filling, photosynthetic characteristics, carbon and nitrogen metabolic enzymes and related gene expression.