Preoperative denosumab combined with microwave ablation for joint preservation in advanced giant cell tumor of bone: a retrospective study.

Background: Preoperative denosumab has been an essential part of the management of giant cell tumor of bone (GCTB) which enhanced subchondral bone integrity and facilitated joint preservation surgery. However, evidence suggests that denosumab-induced sclerotic changes may potentially increase the risk of postoperative recurrence. This study evaluates the efficacy of microwave ablation (MWA) as an adjuvant to intralesional curettage following denosumab treatment in advanced GCTB.

Development of a novel high-frequency reciprocal structure fiber optical pulsed current sensor.

A novel all-fiber optic current sensor (FOCS) is designed specifically for the measurement of large transient currents based on the Faraday effect. A reciprocal symmetric structure is incorporated into the optical sensing loop, and the current dependent phase demodulation is achieved by using a passive optical fiber coupler and the homodyne detection scheme. This design offers several advantages, including structural simplicity, high voltage insulation, low noise, high linearity, and excellent frequency response, and is highly suitable for use in any system of high-voltage, high-power, and high-frequency in nature.

Detection of camellia oil adulteration based on near-infrared spectroscopy and smartphone combined with deep learning and multimodal fusion.

Camellia oil (CO) is known for its nutritional value and health benefits, but its high price makes it susceptible to adulteration. This study developed a binary adulteration system for CO in response to the adulteration of rapeseed oil (RO) into CO that been observed in the market. A total of 243 oil samples adulterated with various concentrations of RO were prepared.

Effects of Peer Video Feedback Based on Cultural Historical Activity Theory in the Operational Training of New Nurses: A Quasi-Experimental Study.

Background: Previous studies have confirmed the potential effectiveness of peer video feedback in the operational training of health care students. However, an appropriate theoretical framework to support peer video feedback has not been established. The cultural historical activity theory (CHAT) provides a suitable framework.

Association of depression with gastroesophageal reflux disease, and the mediating role of risk factors: a Mendelian randomization study.

Background: Growing evidence suggests that depression affects gastroesophageal reflux disease (GERD). But, the relationship between depression and GERD is unclear. To examine the relationship between depression and the risk of GERD, as well as the mediating role of risk factors.

: dual role in promoting growth and development while modulating drought stress tolerance in rice ( L.).

Drought tolerance and plant growth are critical factors affecting rice yield, and identifying genes that can enhance these traits is essential for improving crop resilience and productivity. Using a () mutant of the rice variety Huanghuazhan (HHZ) generated by radiation mutagenesis, we discovered a novel gene, , which plays a dual role in plant biology: it acts as a positive regulator of growth and development, but as a negative regulator of drought resistance. The mutant displayed a marked reduction in plant growth and seed setting rate, yet exhibited an unexpected advantage in terms of drought tolerance.

Measurement of electron and neutral particle densities using a two-color optical fiber interferometer.

A two-color homodyne Mach-Zehnder optical fiber interferometer is developed for the measurement of electron and neutral particle densities in a high-density capsule θ-pinch device. The interferometer leverages the disparate contributions of distinct particles to the refractive index across two discrete wavelengths of 1310 and 1550 nm and incorporates the contributions of both electron and neutral particle densities to the phase shift in the plasma. The temporal evolutions of line-integrated electron and neutral argon densities are successfully measured by the interferometer.

Pancreatic cancer tumor organoids exhibit subtype-specific differences in metabolic profiles.

Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease characterized by complex metabolic rewiring that enables growth in changing nutrient availability and oxygen conditions. Transcriptome-based prognostic PDAC tumor subtypes, known as 'basal-like' and 'classical' subtypes are associated with differences in metabolic gene expression including genes involved in glycolysis. Tumor subtype-specific metabolism phenotypes may provide new targets for treatment development in PDAC, but their functional relevance has not been fully elucidated.

CXCL9/CXCL10 as biomarkers the monitoring of treatment responses in Pulmonary TB patients: a systematic review and meta-analysis.

Background: Tuberculosis (TB) remains a persistent threat to global public health and traditional treatment monitoring approaches are limited by their potential for contamination and need for timely evaluation. Therefore, new biomarkers are urgently required for monitoring the treatment efficacy of TB.

Methods: This study aimed to elucidate the levels of CXCL10 and CXCL9 in pulmonary TB patients who underwent anti-TB treatment.

Combined preoperative denosumab and adjuvant microwave ablation for high-risk giant cell tumor of bone: a retrospective study in a single center.

Background: Giant cell tumor of bone (GCTB) is a locally aggressive neoplasm with a high propensity for recurrence following intralesional curettage. The introduction of denosumab, a RANKL inhibitor, has shown potential in facilitating joint-sparing surgery. However, concerns exist regarding its impact on local recurrence rates.

Determination of Flavonolignan Compositional Ratios in (Milk Thistle) Extracts Using High-Performance Liquid Chromatography.

Milk thistle is one of the most popular ingredients in the liver protection products market. Silymarin is the main component of milk thistle and contains multiple isomers. There have been few studies focusing on the compositional ratios of silymarin isomers.

Comprehensive molecular evolutionary analysis of small heat shock proteins in five diploid Gossypium species.

The small heat shock proteins (sHSPs) are important components in plant growth and development, and stress response. However, a systematical understanding of the sHSP family is yet to be reported in five diploid Gossypium species. In this study, 34 GlsHSPs, 36 GrsHSPs, 37 GtsHSPs, 37 GasHSPs, and 38 GhesHSPs were identified in Gossypium longicalyx, Gossypium raimondii, Gossypium turneri, Gossypium arboreum, and Gossypium herbaceum, respectively.

A comparison of the determination of multiple pesticide residues in fruits, vegetables, and edible fungi using gas chromatography combined with filtration purification and solid-phase extraction.

The multiplug filtration clean-up (m-PFC) and solid-phase extraction (SPE) pretreatment methods were employed to process 8 representative matrices in fruits, vegetables, and edible fungi, respectively. 37 pesticide residues were determined using gas chromatography equipped with ECD and FPD detectors. The measurement data were compared and analyzed following m-PFC purification and gas chromatography analysis, and both accuracy and precision met the (EU) 2021/808 requirements, achieving recovery rates for the 8 matrices ranging from 67.

Nondestructive identification and classification of starch types based on multispectral techniques coupled with chemometrics.

Starch is the main source of energy and nutrition. Therefore, some merchants often illegally add cheaper starches to other types of starches or package cheaper starches as higher priced starches to raise the price. In this study, 159 samples of commercially available wheat starch, potato starch, corn starch and sweet potato starch were selected for the identification and classification based on multispectral techniques, including near-infrared (NIR), mid-infrared (MIR) and Raman spectroscopy combined with chemometrics, including pretreatment methods, characteristic wavelength selection methods and classification algorithms.

Health system barriers to timely routine measles vaccinations in rural southwest China: a qualitative study on the perspectives of township vaccination professionals and village doctors.

Objectives: A well-functioning health system ensures timely routine measles vaccinations for age-appropriate children, minimising measles risk. However, there is limited knowledge about the impact of the performance of immunisation programmes in health systems on the timeliness of measles vaccination. This study aimed to identify health system barriers to timely routine measles vaccination in rural southwest China, integrating the perspectives of township vaccination professionals and village doctors.

Integration of transcriptome and metabolome analyses reveals the role of OsSPL10 in rice defense against brown planthopper.

OsSPL10 is a negative regulator of rice defense against BPH, knockout of OsSPL10 enhances BPH resistance through upregulation of defense-related genes and accumulation of secondary metabolites. Rice (Oryza sativa L.), one of the most important staple foods worldwide, is frequently attacked by various herbivores, including brown planthopper (BPH, Nilaparvata lugens).

HSC-derived exosomal miR-199a-5p promotes HSC activation and hepatocyte EMT via targeting SIRT1 in hepatic fibrosis.

Exosomes have been implicated in inflammation-related diseases, such as hepatic fibrosis (HF) and renal fibrosis, via transferring bioactive cargoes to recipient cells. This study aimed to investigate the possible effect of hepatic stellate cell (HSC)-derived exosomes on the initiation and development of HF by delivering microRNA (miR)-199a-5p. In HF rats with cholestasis induced by ligating the common bile duct, miR-199a-5p was upregulated while SIRT1 was downregulated in liver tissues from bile duct ligation (BDL) rats compared with that of sham rats.

The associations between 2D:4D ratio and behavior problems among Chinese preschool children: A cross-sectional study.

Background: Digit ratio (2D:4D) is considered a biomarker of prenatal androgen activity, the prenatal hormone exposure may affect children's psychology and behavior.

Objective: The aim of this study was to analyze the associations between 2D:4D ratio and behavior problems in Chinese preschool children, and to provide ideas for early intervention of children's behavior problems.

Methods: A total of 548 Chinese preschool children aged 3-6 years were recruited using a stratified cluster sampling method.

Fabrication of sodium alginate-doped carbon dot composite hydrogel and its application for La (III) adsorption and enhanced the removal of phosphorus.

Adsorption is an effective method for the removal of hazardous substances from wastewater. In this work, a low-cost and environmental-friendly composite hydrogel material of sodium alginate doped with nitrogen doped carbon dots (SA@NCDs) was fabricated by impregnation for lanthanide and enhanced phosphorus adsorption in wastewater. The effects of NCDs doping amount, dosage, pH, initial solution concentration, adsorption time and temperature on the process of La (III) adsorption by SA@NCDs were investigated.