Based on Propensity Matching Scores: Comparison of the Mid-term Outcomes of Two Bariatric Surgeries for the Treatment of Obesity and its Complications.

Background: To compare the mid-term efficacy and postoperative complications of two common bariatric procedures-single anastomotic duodeno-ileal bypass with sleeve gastrectomy (SADI-S) and sleeve gastrectomy (SG)-in treating obesity and metabolic syndrome.

Methods: Data from 186 patients undergoing SADI-S or SG between September 2013 and October 2021 were retrospectively analyzed. Propensity score matching (PSM) was applied in a 1:1 ratio, resulting in 78 patients included in the final analysis (39 per group).

Intelligent Hydrogel-Assisted Hepatocellular Carcinoma Therapy.

Given the high malignancy of liver cancer and the liver's unique role in immune and metabolic regulation, current treatments have limited efficacy, resulting in a poor prognosis. Hydrogels, soft 3-dimensional network materials comprising numerous hydrophilic monomers, have considerable potential as intelligent drug delivery systems for liver cancer treatment. The advantages of hydrogels include their versatile delivery modalities, precision targeting, intelligent stimulus response, controlled drug release, high drug loading capacity, excellent slow-release capabilities, and substantial potential as carriers of bioactive molecules.

Machine Learning Integration with Single-Cell Transcriptome Sequencing Datasets Reveals the Impact of Tumor-Associated Neutrophils on the Immune Microenvironment and Immunotherapy Outcomes in Gastric Cancer.

The characteristics of neutrophils play a crucial role in defining the tumor inflammatory environment. However, the function of tumor-associated neutrophils (TANs) in tumor immunity and their response to immune checkpoint inhibitors (ICIs) remains incompletely understood. By analyzing single-cell RNA sequencing data from over 600,000 cells in gastric cancer (GSE163558 and GSE183904), colorectal cancer (GSE205506), and lung cancer (GSE207422), we identified neutrophil subsets in primary gastric cancer that are associated with the treatment response to ICIs.

Noncovalently Bridging Cell-Surface Proteins Using Synthetic Peptides to Modulate Cell Apoptosis.

Controlled high-order clustering of cell-surface proteins is an essential but unmatched regulatory mechanism in living systems for the modulation of cell behavior. Here, we present a strategy for generating extended and tunable one-dimensional clusters of death receptors on live cell surfaces by employing synthetic peptides to noncovalently bridging the proteins. The on-cell assembly process is validated through super-resolution fluorescence imaging and fluorescence lifetime imaging analyses.

Degradable chiral mesoporous silica nanoparticles and carboxymethyl chitosan/cystamine hydrogels for selective loading and controlled release of S-naproxen.

Degradable chiral mesoporous silica nanoparticles (DCMSN) are synthesized for selective loading and controlled release of S-naproxen (S-NPX). Chiral silane coupling agent (APTES-L) and degradable silane coupling agent (APTES-CN) are synthesized, respectively, which are used for the synthesis of DCMSN. APTES-L endows the DCMSN with chirality, while APTES-CN endows the DCMSN with degradability.

Neuron-like lineage differentiation induced by exogenous Neurexin-1 as a potential therapeutic strategy for glioma.

Strategically altering tumor cell fate is a promising treatment for suppressing the malignant phenotype and improving glioma prognosis. This study reveals the favorable impact of the enrichment of neuronal differentiation-related genes on glioma prognosis. A substantial negative correlation was observed between neuronal and mesenchyme-related biological features within gliomas.

Exploring hydrogen adsorption and release in 2D MC-MXenes: structural and functional insights.

Two-dimensional MC-MXenes, characterized by their lightweight nature, tunable surface structures, and strong affinity for hydrogen, hold significant promise for addressing various challenges in hydrogen energy utilization. This study focuses on investigating the hydrogen adsorption and desorption properties, as well as the stability of hydrogenated compounds in 19 pure MC-MXenes nanosheets. The results indicate that hydrogen adsorption on MC primarily occurs through weak physisorption, with MnC and FeC from the fourth period, and AgC and CdC from the fifth period exhibiting the lowest adsorption energies.

Peptide Designs for Cell-Interfacing Assemblies.

Constructing synthetic materials to interact with cells offers significant promise for understanding natural cellular processes and manipulating cell behaviors beyond nature's capabilities. Peptide assemblies are particular promising in this regard, as they have demonstrated efficacy in promoting cell differentiation, repair, and regeneration as supportive scaffolds. However, distinct gaps persist between natural and synthetic assembly systems in various aspects.

Unveiling the molecular and cellular links between obstructive sleep apnea-hypopnea syndrome and vascular aging.

Vascular aging (VA) is a common etiology of various chronic diseases and represents a major public health concern. Intermittent hypoxia (IH) associated with obstructive sleep apnea-hypopnea syndrome (OSAHS) is a primary pathological and physiological driver of OSAHS-induced systemic complications. A substantial proportion of OSAHS patients, estimated to be between 40% and 80%, have comorbidities such as hypertension, heart failure, coronary artery disease, pulmonary hypertension, atrial fibrillation, aneurysm, and stroke, all of which are closely associated with VA.

Development of an automatic tubular chemiluminescence immunoassay using magnetic particles for the detection of antibodies against foot-and-mouth disease virus serotype A.

Foot-and-mouth disease virus (FMDV) causes significant financial losses in animal farms worldwide. Specific antibody monitoring of FMDV post-vaccination is important for evaluating vaccine efficacy, as well as the prevention and control of foot-and-mouth disease (FMD). In this study, we developed a fully automatic tubular chemiluminescence immunoassay method based on magnetic particles (A-MPCLIA) to specifically detect antibodies against FMDV serotype A.

Nonlinear optics of graphitic carbon allotropes: from 0D to 3D.

The dimensionality of materials fundamentally influences their electronic and optical properties, presenting a complex interplay with nonlinear optical (NLO) characteristics that remains largely unexplored. In this review, we focus on the influence of dimensionality on the NLO properties of graphitic allotropes, ranging from 0D fullerenes, 1D carbon nanotubes, and 2D graphene, to 3D graphite, all of which share a consistent sp hybridized chemical bonding structure. We examine the distinct physical and NLO properties across these dimensions, underscoring the profound impact of dimensionality.

The declining effectiveness of air quality index in China: A perspective of air pollution alert system.

Since 2013, the air quality in China has improved dramatically. However, the regulatory standard as defined in air quality index (AQI) is still the one introduced in 2012. To evaluate the gap between reality and regulation, we study the effectiveness of China's AQI from the perspective of air pollution alert, a system that reflects AQI standard directly.

Self-Assembled Peptide Sheet-Mediated Multivalent Capture of Cells with Enhanced Tunability.

We report the creation of multivalent ligand surfaces for cell capture by conjugation of ligand-appended 2D peptide assemblies on an antifouling glass substrate. The sheet-like structures organize ligands into non-uniform, patchy patterns, enhancing multivalent cell targeting. A 155 % increase in captured cells was achieved compared to the presentation of the ligands on surfaces lacking the peptide sheets.

Multi-habitat utilization and diverse life history of the endangered Sea Carp (Cyprinus acutidorsalis) in the Wanquan Estuary, Hainan island, China: Evidence from otolith microchemistry.

The Sea Carp Cyprinus acutidorsalis (Wang) is an endemic species limited to a few estuaries in China, uniquely adapted to long-term residence in brackish water environments. This species is endangered due to anthropogenic disturbances, and its life history and habitat use remain poorly understood. This study is the first to investigate the life history and habitat utilization of Sea Carp in the Wanquan Estuary, Hainan Province, China, using otolith microchemistry.