Prognostic and predictive value of radiomic signature in stage I lung adenocarcinomas following complete lobectomy.

Background: The overall survival (OS) of stage I operable lung cancer is relatively low, and not all patients can benefit from adjuvant chemotherapy. This study aimed to develop and validate a radiomic signature (RS) for prediction of OS and adjuvant chemotherapy candidates in stage I lung adenocarcinoma.

Methods: A total of 474 patients from 2 centers were divided into 1 training (n = 287), 1 internal validation (n = 122), and 1 external validation (n = 65) cohorts.

Deep Learning for Additive Screening in Perovskite Light-Emitting Diodes.

Additive engineering with organic molecules is of critical importance for achieving high-performance perovskite optoelectronic devices. However, experimentally finding suitable additives is costly and time consuming, while conventional machine learning (ML) is difficult to predict accurately due to the limited experimental data available in this relatively new field. Here, we demonstrate a deep learning method that can predict the effectiveness of additives in perovskite light-emitting diodes (PeLEDs) with a high accuracy up to 96 % by using a small dataset of 132 molecules.

Multifunctional Fiber-Enabled Intelligent Health Agents.

The application of wearable devices is promoting the development toward digitization and intelligence in the field of health. However, the current smart devices centered on human health have disadvantages such as weak perception, high interference degree, and unfriendly interaction. Here, an intelligent health agent based on multifunctional fibers, with the characteristics of autonomy, activeness, intelligence, and perceptibility enabling health services, is proposed.

Access to Healthcare and the Utilization of Sexually Transmitted Infections Among Homeless Medicaid Patients 15 to 44 Years of Age.

Homelessness poses a direct threat to public health in the US as many individuals face debilitating health outcomes and barriers to adequate health care. Access to STI care for the homeless Medicaid population of USA has not been well-studied using administrative claims data. Our study aims to compare health services utilization, STI screening and diagnoses among people experiencing homelessness (PEH) vs.

Effects of High Temperatures on the Performance of Carbon Fiber Reinforced Polymer (CFRP) Composite Cables Protected with Fire-Retardant Materials.

In this study, the safe critical temperature that can be tolerated by CFRP tendons under normal working conditions was derived through tensile tests at room and high temperatures. Next, the times required to reach a safe critical temperature for CFRP cables protected with different types of fire-retardant materials of various thicknesses were determined through fire resistance tests, Finally, fitting the surface of the finite element simulation results allowed the establishment of the temperature rise calculation model of CFRP tendons under the protection of fire-retardant materials. The results showed that 300 °C can be regarded as the safe critical temperature.

Path Analysis Reveals the Direct Effect of PCB28 Exposure on Cognitive Dysfunction in Older Chinese Females.

Background: Research indicates that exposure to polychlorinated biphenyls (PCBs) can cause neurobehavioral impairments in neonates and adults, but the way specific PCBs’ congeners impact cognition functions at a low exposure level in a real-life co-exposure system remains poorly understood. This study aimed to investigate the association of PCBs burden with cognition function among elderly adults. Methods: Based on the Weitang Geriatric Diseases study (2014−2015), the current study measured the plasma concentrations of six indicator-PCBs by GC-MS/MS and assessed the cognitive dysfunction (CoD) via an Abbreviated Mental Test in 266 participants (ages 61−90).

Hydrogen-bonding and "π-π" interaction promoted solution-processable mixed matrix membranes for aromatic amines detection.

Detection of hazardous compounds can alleviate risk to human health. However, it remains a challenge to develop easy-to-use testing tools for carcinogenic aromatic amines. Herein, we presented a conjugated molecule-based aniline detector, mixed matrix membranes (MMMs), through the solution-processable strategy.

A randomized, placebo-controlled clinical trial of hydrogen/oxygen inhalation for non-alcoholic fatty liver disease.

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide with increasing incidence consistent with obesity, type 2 diabetes and cardiovascular diseases. No approved medication was currently available for NAFLD treatment. Molecular hydrogen (H ), an anti-oxidative, anti-inflammatory biomedical agent is proved to exhibit therapeutic and preventive effect in various diseases.

Clinical, radiologic, and physiologic features of idiopathic pulmonary fibrosis (IPF) with and without emphysema.

Background: Idiopathic pulmonary fibrosis (IPF) can combine with emphysema, a condition termed as IPF with emphysema (IPFE). We compared the clinical, radiologic, and physiologic features of IPF and IPFE.

Research Design And Methods: Newly diagnosed IPF    and IPFE    patients were recruited between January 2018 and September 2020.

Irinotecan decreases intestinal UDP-glucuronosyltransferase (UGT) 1A1 via TLR4/MyD88 pathway prior to the onset of diarrhea.

Irinotecan is a first-line treatment for colorectal cancer and the prodrug of 7-ethyl-10-hydroxy-camptothecin (SN-38). However, its fatal gastrointestinal (GI) toxicity raises serious concern. In liver, irinotecan generates its inactive metabolite, SN-38G via UDP-glucuronosyltransferase (UGT)1A1.

Sexually Transmitted Infection Testing, Prevalence, and Treatment Among Individuals Receiving HIV Preexposure Prophylaxis Within an Integrated Healthcare Delivery System.

Background: Initial and follow-up sexually transmitted infection (STI) and human immunodeficiency virus (HIV) testing are recommended when taking HIV preexposure prophylaxis (PrEP). We assessed STI services before and after PrEP initiation among persons 18 years or older.

Methods: We conducted this retrospective cohort study at a US integrated healthcare delivery system.

Abnormal Reginal Homogeneity in Left Anterior Cingulum Cortex and Precentral Gyrus as a Potential Neuroimaging Biomarker for First-Episode Major Depressive Disorder.

Objective: There is no objective method to diagnose major depressive disorder (MDD). This study explored the neuroimaging biomarkers using the support vector machine (SVM) method for the diagnosis of MDD.

Methods: 52 MDD patients and 45 healthy controls (HCs) were involved in resting-state functional magnetic resonance imaging (rs-fMRI) scanning.

Interactive impacts of microplastics and chlorine on biological stability and microbial community formation in stagnant water.

Possibility of human exposure to microplastics (MPs) in water environment has been escalating, and subsequent challenges of MPs to biostability and biosafety in drinking water deserve more attention, especially in stagnant water. The present study explored the integrated impacts of MPs and chlorine on disinfection kinetics, microbial growth, and microbial community formation in drinking water, by setting MPs or microplastic-biofilm (MP-BM) under different disinfection conditions. The following were the primary conclusions: (1) The presence of MP and MP-BM led to the deterioration of water indices (especially turbidity) when chlorine was less than 1 mg/L.

Growth characteristics of and mechanical properties of slope with different sludge contents.

The utilization of dredged sludge can reduce environmental pollution and save land resources. To explore using sludge resources in ecological slope-protection projects, dredged sludge was incorporated into ecological slope-protection soil. was planted to analyze the effect of sludge content on its growth.

Longitudinal prediction of lung nodule invasiveness by sequential modelling with common clinical computed tomography (CT) measurements: a prediction accuracy study.

Background: Accurate preoperative prediction of the invasiveness of lung nodules on computed tomography (CT) can avoid unnecessary invasive procedures and costs for low-risk patients. While previous studies approached this task using cross-sectional data, this study aimed to utilize the commonly available longitudinal data of lung nodules through sequential modelling based on long short-term memory (LSTM) networks.

Methods: We retrospectively included 171 patients with lung nodules that were followed-up at least once and pathologically diagnosed with adenocarcinoma for model development.

Comprehensive lipidomic analysis of milk polar lipids using ultraperformance supercritical fluid chromatography-mass spectrometry.

Polar lipids in milk are receiving increasing interest due to their bioactivities. However, milk polar lipids present a wide range of physical-chemical properties at different concentrations, making their analysis challenging. In this study, we presented a comprehensive lipidomic method using ultraperformance supercritical fluid chromatography (UPSFC)-quadrupole-time of flight-mass spectrometry (Q-TOF-MS), which enabled the separation of 18 lipid classes (including nonpolar lipids, cholesterol, ceramide, glycerophospholipids, sphingomyelin, and gangliosides) within 10 min.

Giant excitonic upconverted emission from two-dimensional semiconductor in doubly resonant plasmonic nanocavity.

Phonon-assisted upconverted emission is the heart of energy harvesting, bioimaging, optical cryptography, and optical refrigeration. It has been demonstrated that emerging two-dimensional (2D) semiconductors can provide an excellent platform for efficient phonon-assisted upconversion due to the enhanced optical transition strength and phonon-exciton interaction of 2D excitons. However, there is little research on the further enhancement of excitonic upconverted emission in 2D semiconductors.

Optimizing Evanescent Efficiency of Chalcogenide Tapered Fiber.

Evanescent wave absorption-based mid-infrared chalcogenide fiber sensors have prominent advantages in multicomponent liquid and gas detection. In this work, a new approach of tapered-fiber geometry optimization was proposed, and the evanescent efficiency was also theoretically calculated to evaluate sensing performance. The influence of fiber geometry (waist radius (), taper length (), waist deformation) on the mode distribution, light transmittance (), evanescent proportion () and evanescent efficiency () is discussed.

Engineered non-covalent π interactions as key elements for chiral recognition.

Molecular recognition and self-assembly are often mediated by intermolecular forces involving aromatic π-systems. Despite the ubiquity of such interactions in biological systems and in the design of functional materials, the elusive nature of aromatic π interaction results in that they have been seldom used as a design element for promoting challenging chemical reactions. Described here is a well-engineered catalytic system into which non-covalent π interactions are directly incorporated.

Computer tomography-guided negative pressure drainage treatment of intrathoracic esophagojejunal anastomotic leakage: A case report.

Background: Esophagojejunal anastomotic leakage (EJAL) is a serious and potentially crucial complication of total gastrectomy and represents the major cause of postoperative death, with a mortality rate of up to 50%. However, treatment remains challenging and controversial. We report here the case of a patient whose intrathoracic EJAL was successfully treated with computer tomography (CT)-guided negative pressure drainage treatment.

Biomimetic Design and Fabrication of Sericin-Hydroxyapatite Based Membranes With Osteogenic Activity for Periodontal Tissue Regeneration.

The guided tissue regeneration (GTR) technique is a promising treatment for periodontal tissue defects. GTR membranes build a mechanical barrier to control the ingrowth of the gingival epithelium and provide appropriate space for the regeneration of periodontal tissues, particularly alveolar bone. However, the existing GTR membranes only serve as barriers and lack the biological activity to induce alveolar bone regeneration.

Triacylglycerol regioisomers containing palmitic acid analyzed by ultra-performance supercritical fluid chromatography and quadrupole time-of-flight mass spectrometry: Comparison of standard curve calibration and calculation equation.

Triacylglycerol (TAG) regioisomers containing palmitic acid (16:0) was identified using ultra-performance supercritical fluid chromatography and quadrupole time-of-flight mass spectrometry (UPSFC-Q-TOF-MS) and quantified using calibration curve method and calculation equation method. There were negative linear correlation between [R]/[R+[R] and content of sn-A-B-A (%) for AAB/ABA type TAGs, [R]/[R+[R]+[R] and content of fatty acid (FA) at sn-2 position (%) for BAC/ABC/ACB type TAGs. The difference between calculation equation and standard curve method was acceptable.

Thyroid-disrupting effects caused by exposure to alternative flame retardants from groundwater contamination in rural central China.

Accumulating evidence reveals that exposure to alternative flame retardants (AFRs) results in defective thyroid functions. AFRs are detectable in various environmental media in developed cities in China. However, few studies have reported the contamination levels of AFR in groundwater in rural areas, indicating an urgent need to investigate exposure of AFRs and perform health risk assessment for populations that use groundwater as the main source of drinking water.

The role of ephrinB2-EphB4 signalling in bone remodelling during orthodontic tooth movement.

Objective: The aim of this study was to investigate the role of ephrinB2-EphB4 signalling in alveolar bone remodelling on the tension side during orthodontic tooth movement (OTM).

Materials And Methods: An OTM model was established on sixty 8-week-old male Wistar rats. They were randomly divided into the experimental group and the control group.