Fe diaspora titanium dioxide and graphene: A study of conductive powder materials and coating applications.

Developing new conductive primers to ensure electrostatic spraying is crucial in response to the call for lightweight production of new energy vehicles. We report a stabilized material, Fe-T/G, of Fe-doped TiO composite graphene synthesized by a simple hydrothermal and electrostatic self-assembly method. The resistivity decreases from 0.

Drugs exhibit diverse binding modes and access routes in the Nav1.5 cardiac sodium channel pore.

Small molecule inhibitors of the sodium channel are common pharmacological agents used to treat a variety of cardiac and nervous system pathologies. They act on the channel via binding within the pore to directly block the sodium conduction pathway and/or modulate the channel to favor a non-conductive state. Despite their abundant clinical use, we lack specific knowledge of their protein-drug interactions and the subtle variations between different compound structures.

The regulatory role of the Netrin-1/UNC5H3 pathway in neuronal pyroptosis after stroke.

Currently, stroke is a disease with high disability and mortality risks and no effective treatment. The pathogenesis and molecular mechanisms of neuronal damage in stroke are highly complex. Pyroptosis participates in neuronal death after stroke.

Effects of MAO‑B inhibitors in life quality of Parkinson's disease patients: A systematic review and meta‑analysis.

Introduction: Monoamine oxidase-B (MAO-B) inhibitors, as an add-on therapy to levodopa, are widely used in Parkinson's disease (PD). The effects of MAO-B inhibitors on quality of life remain unclear, and the aim of this systematic review and meta-analysis was to assess the efficacy and safety of MAO-B inhibitors on quality of life in different domains.

Methods: We searched PubMed, Embass, and Cochrane Library databases for randomized controlled trials of PD patients who were administered MAO-B inhibitors.

Novel pathogenic ATM mutation with ataxia-telangiectasia in a Chinese family.

Ataxia-Telangiectasia (A-T) is a rare, autosomal recessive disorder characterized by progressive cerebellar ataxia, oculocutaneous telangiectasia, immunodeficiency, and increased cancer risk. Mutations in the ATM gene, which is essential for DNA damage repair, underlie this condition. This study reports a novel homozygous frameshift mutation (ATM_ex20 c.

Unraveling the gut: the pivotal role of intestinal mechanisms in Kawasaki disease pathogenesis.

Kawasaki disease (KD), an acute systemic vasculitis that primarily affects children under 5 years of age, is the leading cause of acquired heart disease in this age group. Recent studies propose a novel perspective on KD's etiology, emphasizing the gastrointestinal (GI) tract, particularly the role of gut permeability. This review delves into how disruptions in gut barrier function trigger systemic inflammatory responses, exacerbate vascular inflammation, and contribute to coronary artery aneurysms.

Serum C-Reactive Protein-to-Albumin Ratio as a Clinical Risk Factor for Traumatic Spinal Cord Injury.

Objective: To evaluate the effects of admission serum C-reactive protein-to-albumin ratio (CAR) in traumatic spinal cord injury (TSCI) severity evaluation and prognosis.

Methods: We included 402 TSCI patients from 2 hospitals and collected relevant clinical and laboratory data. The effects of CAR on the prognosis of TSCI were explored using univariate and multivariate logistic regression analyses.

Structural regulation of alginate-based adsorbents based on different coordination configurations of metal ions and selective adsorption of copper ion.

To tackle the problem of developing efficient adsorbents for the selective removal of copper ions from wastewater, this investigation focused on the synthesis of Fe-GO/MMT/SA and Al-GO/MMT/SA copper ion adsorbent materials (Fe-GMS and Al-GMS), respectively, by merging two distinct metal ions (Fe(III) and Al(III)) with sodium alginate (SA), graphene oxide (GO), and montmorillonite (MMT). By introducing metal ions with different coordination configurations, the slit structure and pore density of the adsorbents can be effectively controlled, thereby enhancing the selectivity for copper ion adsorption. The results show that Fe-GMS has excellent adsorption capacity for Cu(II) compared with Al(III), and the adsorption capacity and distribution coefficient are 116.

Chitosan-based composite featuring dual cross-linking networks for the removal of aqueous Cr(VI).

To avoid the environmental detriment caused by Cr(VI) waste, this study constructs a dual cross-linking network structure using sodium alginate (SA) and polyvinyl alcohol (PVA). Chitosan (CS) is further introduced through electrostatic attraction and hydrogen bonding and SA/PVA/CS (SPC) composite with porous structure is successfully prepared for the removal of Cr(VI) from wastewater. Batch adsorption experiments show that SPC has excellent adsorption capacity and practical usability with a broad pH applicability range.

Understanding of manganese-sulfur functionalized biochar: Bridging effect enhanced specific passivation of lead in soil.

Widespread contamination of soils by neurotoxic lead ions (Pb) posed a serious risk to food security, but efficient treatment in soil remained a challenge. For the adsorption of Pb, DFT calculations were firstly performed to predict the synergistic effect of sulfhydryl-hydroxyl groups as well as the ability of sulfur ions to strengthen Pb-OH bonding. Consequently, Mn-S functionalized coffee ground biochar (MSBC) was then synthesized utilizing precipitation and impregnation methods.

The potential role of heparin-binding protein in neonatal sepsis: research progress.

Neonatal sepsis is a major global health challenge, leading to significant morbidity and mortality in newborns. The search for precise biomarkers for its early prediction in clinical settings has been ongoing, with heparin-binding protein (HBP) emerging as a promising candidate. Originating from granules in neutrophils, HBP is released into the bloodstream in response to infection and plays a pivotal role in the body's inflammatory response.

Selective adsorption of Cu(II) on amino-modified alginate-based aerogel: As a catalyst for the degradation of organic contaminant.

In this study, amino-modified graphene oxide(NGO) was prepared by introducing amino functional groups. Based on the cross-linking between Ca(II) and sodium alginate (SA), associated with dense slit-like pore resulted from the nano-sheet accumulation of NGO and montmorillonite (MMT), composite aerogels (NGM) with stable pore structure were constructed, thus it realized the selective recovery of hydrated copper ions in complex wastewater systems. Raman analysis and density functional theory calculation confirmed the construction of amino-modified defect GO and significantly improved its chemical reactivity, which laid the foundation for the construction of slit pore structure of NGM (SEM can confirm).

Case report: A pregnant woman accidental treated with spironolactone in mid-gestation.

Spironolactone, a potassium-sparing diuretic, is used to treat hypertension, heart failure, and certain hyperandrogenic disorders. Its use during pregnancy is not recommended due to the risk of feminizing male fetuses, primarily because of its antiandrogenic activity. However, human data remain scarce and largely inconclusive.

Effect of β-lactam antibiotics on the gut microbiota of term neonates.

β-Lactam antibiotics are a class of antibiotics commonly used to treat bacterial infections. However, the effects of β-lactam antibiotics on term neonatal intestinal flora have not been fully elucidated. Hospitalized full-term newborns receiving β-lactam antibiotics formed the antibiotic group (n = 67), while those without antibiotic treatment comprised the non-antibiotic group (n = 47).

Case Report: Taking action or standing by: managing a preterm neonate at the risk of neonatal varicella by metagenomic next-generation sequencing.

Neonatal varicella is indeed a rare condition, and most infants born to mothers with varicella have a good prognosis. However, in exceptional cases, neonatal varicella can be life-threatening, particularly for preterm infants. Therefore, it is vital to make an early diagnosis or predict the risk of neonatal varicella to ensure prompt treatment and improve prognosis.

Incidence and prevalence of Alzheimer's disease in China: a systematic review and meta-analysis.

As China faces demographic shifts and socioeconomic changes, the burden of Alzheimer's disease (AD) and associated cognitive impairments is increasing dramatically, with significant implications for public health and the economy. This systematic review and meta-analysis aims to provide a comprehensive assessment of the prevalence and incidence of AD across China. Drawing from an extensive search of international and Chinese databases up to August 27, 2023, including PubMed, Embase, and the Cochrane Library, we synthesized data from 105 studies.

Mycobacterial Biofilm: Mechanisms, Clinical Problems, and Treatments.

Tuberculosis (TB) remains a threat to human health worldwide. (Mtb) and other nontuberculous mycobacteria (NTM) can form biofilms, and in vitro and animal experiments have shown that biofilms cause serious drug resistance and mycobacterial persistence. Deeper investigations into the mechanisms of mycobacterial biofilm formation and, consequently, the exploration of appropriate antibiofilm treatments to improve the efficiency of current anti-TB drugs will be useful for curing TB.

Case report: Acute severe hyponatremia-induced seizures in a newborn: a community-acquired case and literature review.

Severe neonatal hyponatremia represents a critical electrolyte imbalance with potentially severe neurological outcomes, a condition rarely documented in community-acquired, full-term newborns. This report underscores a unique case of a 23-day-old, previously healthy, full-term male neonate experiencing severe hyponatremia that precipitated seizures, underscoring the urgency of prompt recognition and intervention. The neonate presented with symptoms including vomiting, groaning, chills, fixed staring, and limb tremors.

Olfactory Dysfunction and Long-Term Trajectories of Sleep Disorders among early Parkinson's Disease: Findings from a Longitudinal Cohort.

Background: Previous studies have suggested a connection between impaired olfactory function and an increased risk of rapid eye movement sleep behavior disorder (RBD) in individuals diagnosed with Parkinson's disease (PD). However, there is a gap in knowledge regarding the potential impact of olfactory dysfunction on the long-term patterns of sleep disorders among early PD patients.

Methods: Data from the Parkinson's Progression Markers Initiative program included 589 participants with assessments of sleep disorders using the Epworth Sleepiness Scale (ESS) and RBD Screening Questionnaire (RBDSQ).

Dynamic impact of delivery modes on gut microbiota in preterm infants hospitalized during the initial 4 weeks of life.

Preterm infants face a high risk of various complications, and their gut microbiota plays a pivotal role in health. Delivery modes have been reported to affect the development of gut microbiota in term infants, but its impact on preterm infants remains unclear. Here, we collected fecal samples from 30 preterm infants at five-time points within the first four weeks of life.