Publications by authors named "Tanya Sperling"
Article Synopsis
- HPV8, a type of human papillomavirus linked to skin cancer, affects immune cell presence and inflammation in patients with epidermodysplasia verruciformis (EV).
- The study found that HPV8 E6 significantly induces the chemokine CCL2, attracting monocytes and leading to a predominance of macrophages in the lesions, surpassing even pro-inflammatory cytokines like TNF-α.
- Researchers highlighted a specific mechanism involving the C/EBPα/miR-203/p63 pathway in how HPV8 E6 influences CCL2 production, showing that HPV8's oncoproteins disrupt skin immune balance for viral persistence.
Infection with genus beta human papillomaviruses (HPV) is implicated in the development of non-melanoma skin cancer. This was first evidenced for HPV5 and 8 in patients with epidermodysplasia verruciformis (EV), a genetic skin disease. So far, it has been unknown how these viruses overcome cutaneous immune control allowing their persistence in lesional epidermis of these patients.
View Article and Find Full Text PDFThe papillomavirus life cycle parallels keratinocyte differentiation in stratifying epithelia. We have previously shown that the human papillomavirus type 8 (HPV8) E2 protein downregulates beta4-integrin expression in normal human keratinocytes, which may trigger subsequent differentiation steps. Here, we demonstrate that the DNA binding domain of HPV8 E2 is sufficient to displace a cellular factor from the beta4-integrin promoter.
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