Hemostatic Management of Trauma-Induced Coagulopathy.

Trauma-induced coagulopathy is a primary factor in many trauma-related fatalities. Management hinges upon rapid diagnosis of coagulation abnormalities and immediate administration of appropriate hemostatic agents. Use of crystalloids and packed red blood cells has traditionally been the core of trauma resuscitation, but current massive transfusion protocols include combination therapy with fresh frozen plasma and predefined ratios of platelets to packed red blood cells, limiting crystalloid administration.

Rhabdomyolysis in a patient receiving ranolazine and simvastatin.

Purpose: A case of rhabdomyolysis occurring shortly after the addition of ranolazine to a stable simvastatin regimen is reported.

Summary: A 63-year-old Caucasian man with a history of hyperlipidemia and coronary artery disease arrived at an urgent care center with complaints of worsening bilateral lower-extremity weakness over three days. He was admitted to a hospital within 24 hours.