Publications by authors named "Tanya N Basu"
In 2020, Beck et al described a novel adult autoinflammatory syndrome entitled VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic), a newly-discovered disorder that connected previously unrelated inflammatory syndromes and a prototype for a new class of hematoinflammatory diseases. Eighty-nine percent of published cases have documented skin involvement, but despite the high incidence and diagnostic accessibility of skin manifestations, there has been little focus on the dermatological features of VEXAS syndrome thus far. A PubMed search of all published case reports of VEXAS syndrome to date was performed, with inclusion of all cases confirmed by genetic sequencing, and this review summarizes the reported dermatological signs.
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- * Patients showed ACV resistance after having chronic graft versus host disease (cGVHD), and all developed severe oral mucositis while on ACV prophylaxis, experiencing complications despite switching to foscarnet for treatment.
- * The prolonged immunosuppression and extended aciclovir use in these patients highlight the need for vigilant monitoring and alternative treatments for HSV in HSCT recipients.
Article Synopsis
- * The study presents four cases (two CMML and two MDS) where severe itching occurred, with some symptoms showing up months before the cancer diagnosis.
- * Chemotherapy and immunosuppressive treatments have mixed results on alleviating the itch, indicating that recognizing this symptom could help in the earlier diagnosis of these blood disorders.
Aims: Acute graft-versus-host disease (aGVHD) is a leading cause of morbidity and mortality following allogeneic haematopoietic stem cell transplantation (HSCT). The aim of this study was to evaluate the clinical utility of a composite biomarker panel to help identify individuals at risk of developing aGVHD, and to help predict and differentiate between severity of aGVHD following T-cell-depleted allogeneic HSCT.
Methods: We retrospectively analysed our cohort of biopsy confirmed patients with aGVHD, who underwent T-cell-depleted HSCT and matched them with negative controls without any evidence of aGVHD.