Individual capacity-building approaches in a global pharmaceutical systems strengthening program: a selected review.

Background: Medicines use related challenges such as inadequate adherence, high levels of antimicrobial resistance and preventable adverse drug reactions have underscored the need to incorporate pharmaceutical services to help achieve desired treatment outcomes, and protect patients from inappropriate use of medicines. This situation is further constrained by insufficient numbers of pharmaceutical personnel and inappropriate skill mix. Studies have addressed individual capacity building approaches of logistics, supply chain or disease specific interventions but few have documented those involving such pharmacy assistants/professionals, or health workers/professionals charged with improving access and provision of pharmaceutical services.

Estimating the herd immunity effect of rotavirus vaccine.

Introduction: Diarrhea is one of the leading causes of death in children under 5, and an estimated 39% of these deaths are attributable to rotavirus. Currently two live, oral rotavirus vaccines have been introduced on the market; however, the herd immunity effect associated with rotavirus vaccine has not yet been quantified. The purpose of this meta-analysis was to estimate the herd immunity effects associated with rotavirus vaccines.

How within-country inequalities and co-coverage may affect LiST estimates of lives saved by scaling up interventions.

Lives-saved estimates calculated by LiST include the implicit assumptions that there are no inequalities among different socioeconomic groups, and also that the likelihood of a mother or child receiving a given intervention is independent from the probability of receiving any other interventions. It is reasonable to assume that, as a consequence of these assumptions, LiST estimates may exaggerate the numbers of lives saved in a population, by ignoring the fact that coverage is likely to be lower and mortality higher among the poor than the rich, and also by failing to take into account that coverage with different interventions may be clustered at individual mothers and children--a phenomenon described as co-coverage. We used data from 127 DHS surveys to estimate how much these two assumptions may bias estimates produced by LiST, and conclude that under real-life conditions bias occurred in both directions, with LiST results either over or underestimating the more complex estimates.

NMDA receptor activation by HIV-Tat protein is clade dependent.

In countries infected with HIV clade B, some patients develop a rapidly progressive dementia that if untreated results in death. In regions of the world infected with HIV clade C, only milder forms of cognitive impairment have been recognized. HIV-infected macrophages are the principal mediators of dementia.