High-resolution computed tomography imaging of airway disease in infants with cystic fibrosis.

Rationale: The development of early lung disease in patients with cystic fibrosis (CF) remains poorly defined.

Objective: Determine whether asymptomatic infants with CF have evidence for changes in airway structure when assessed by high-resolution computed tomography, and whether airway structure correlates with airway function in this age group.

Methods: Thirteen infants with CF (8-33 mo) and 13 control infants (7-25 mo) were evaluated.