16/18 genotyping in triage of persistent human papillomavirus infections with negative cytology in the English cervical screening pilot.

Background: In the English pilot of primary cervical screening with high-risk human papillomavirus (HR-HPV), we exploited natural viral clearance over 24 months to minimise unnecessary referral of HR-HPV+ women with negative cytology. Three laboratories were permitted to use 16/18 genotyping to select women for referral at 12-month recall. We estimated the clinical impact of this early genotyping referral.

Primary cervical screening with high risk human papillomavirus testing: observational study.

Objective: To provide the first report on the main outcomes from the prevalence and incidence rounds of a large pilot of routine primary high risk human papillomavirus (hrHPV) testing in England, compared with contemporaneous primary liquid based cytology screening.

Design: Observational study.

Setting: The English Cervical Screening Programme.

'Herpes present' reported in a routine cervical cytology and how to deal with it.

In spite of advances in processing and interpreting liquid based cervical cytology, the reliability of diagnosing genital herpes from cervical cytology specimens is disputed. This letter highlights the issues when 'herpes present' is reported in routine smears taken from asymptomatic women.

The effects of a graduated aerobic exercise programme on cardiovascular disease risk factors in the NHS workplace: a randomised controlled trial.

Background: Sufficient levels of physical activity provide cardio-protective benefit. However within developed society sedentary work and inflexible working hours promotes physical inactivity. Consequently to ensure a healthy workforce there is a requirement for exercise strategies adaptable to occupational time constraint.

Idiopathic intimal hyperplasia of small arteries and arterioles affecting intestines and myocardium.

We report the case of a 52-year-old woman dying from a noninflammatory, occlusive vasculopathy. Histology showed marked intimal hyperplasia of small arteries of the intestines and myocardium with subsequent infarction of myocardium, large intestine and gallbladder. A comprehensive work up including laboratory studies, clinical investigations and postmortem failed to assign this condition to any of the known vascular diseases.