Carvacrol-Induced Vacuole Dysfunction and Morphological Consequences in and .

With the prevalence of systemic fungal infections caused by and non- species and their resistance to classical antifungals, there is an urgent need to explore alternatives. Herein, we evaluate the impact of the monoterpene carvacrol, a major component of oregano and thyme oils, on clinical and laboratory strains of and . Carvacrol induces a wide range of antifungal effects, including the inhibition of growth and hyphal and biofilm formation.

Cinnamon Leaf and Clove Essential Oils Are Potent Inhibitors of Virulence Traits.

Plant-based essential oils are promising anti-virulence agents against the multidrug-resistant opportunistic pathogen . Gas chromatography-mass spectrometry of (cinnamon) leaf and (clove) flower bud essential oils revealed eugenol (73 and 75%, respectively) as their major component, with β-caryophyllene, eugenyl acetate, and α-humulene as common minor components. Cinnamon leaf and clove essential oils had minimum inhibitory concentrations of 600 and 500 µg/mL, respectively against the RSY150 reference strain and 1000 and 750 µg/mL, respectively for the clinical reference strain ATCC 10231.