Clinical Evaluation and Management of Cancer Survivors with Radiation Fibrosis Syndrome.

Objectives: To define radiation fibrosis and radiation fibrosis syndrome; review the basics of radiotherapy, the pathophysiology of radiation injury, and the principles of clinical evaluation and management of the common late effects resulting from radiation therapy for cancer treatment.

Data Sources: Peer-reviewed journal articles, book chapters, Internet.

Conclusion: There is no cure for radiation fibrosis syndrome, but supportive treatment of its clinical sequelae can potentially result in improved function and quality of life.