Publications by authors named "Tanvi K Sondhi"
Chem Biomed Imaging
November 2024
Article Synopsis
- Macrophages can behave in two main ways when activated: inflammatory (M1) or anti-inflammatory (M2), and tracking these behaviors is important for understanding immune function.
- Current methods for monitoring macrophage polarization are either static or not suitable for complex environments, so the researchers developed a new approach using genetically engineered luciferase reporters.
- Their method allows for long-term observation of macrophage types in both 2D and 3D formats with high resolution, paving the way for better monitoring of immune cells and other complex biological networks.
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Article Synopsis
- Macrophages can be classified into two types based on activation: inflammatory (M1) and anti-inflammatory (M2), which are important for understanding immune function.
- Current methods for tracking these types are limited in their ability to provide real-time data, especially in complex 3D environments.
- This study introduces new bioluminescent technologies that allow for long-term monitoring of macrophage polarization using genetically engineered reporters, enhancing the ability to observe these cells in living samples and enabling more detailed analysis in various settings.
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