[Allergic inflamation of the lower airways in patients with allergic rhinitis].

Reporting two of our cases we wanted to point to a great dilemma related to the final diagnosis. Recently, such cases have been more frewuently seen, since in all patients with allergic rhinitis conditions of the lower airways is examined before the administration of the specific immunotherapy. Therefore, we may see patients who are still free of pulmonary sings, despite of positive specific and/or non specific bronchoprovocative tests.

[Allergic reactions of the lower airways in two patients with seasonal allergic rhinitis].

The paper presents two patients with seasonal allergic rhinitis. Absence of complaints related to the lower airways, normal physical pulmonary findings, normal functional ventilation findings and negative non-specific bronchoprovokative metacholine test, ruled out bronchial asthma in both patients. However, positive specific bronchoprovokative tests with corresponding allergens were explained by the presence of the specifically sensibilised mast cells at the level of the lower airways and allergic reaction in absence of allergic inflammation and bronchial hyperirritability.

[Allergic reaction of the lower airways of non asthmatic patients caused by grass pollen].

Having in mind importance of early detection of the disease, in it phase of development, we have reported a case with seasonal allergic rhinitis and allergic reaction of the lower airways in absence of allergic inflammation and clinically evident bronchial asthma.

[Antinuclear antibodies detection in both HEp-2 cells and tissue section of the rat liver using indirect imunofluorescence].

Having in mind the importance of indirect immunofluorescence in antinuclear antibodies detection, the study was aimed to compare characteristics of fluorescent visualization and specificity of HEp-2 cells with tissue cryosections of the rat liver. The study included 76 serum samples obtained from patients with systemic connective tissue diseases. Out of that number, fluorescence findings on HEp-2 cells and rat liver tissue were positive in 74 and 54 patients, respectively.

[The influence of parathyroidectomy on phagocytic capability of polymorphonuclear cells in patients on hemodialysis].

Having in mind the fact, that in patients with secondary hyperparathyroidism induced by chronic renal failure, phagocytic capability of leukocytes is supressed, we attempted to investihate the role of parathormone in it. The study included 6 hemodialysed and 5 healthy volunteers. The degree of phagocyosis was determined according to the HBT test on polymorphonuclear leukocytes (PMNL), before, and 7 and 60 days following the subtotal parathyroodectomy.

[Simultaneous recording of nonspecific bronchial response using continuous measurement of total respiratory resistance and oxygen saturation of arterial blood].

In 78 patients with bronchial asthma symptoms undergoing nonspecific bronchial response test with bronchoprovocation inhalation of progressively increased methacholine concentrations, total respiratory resistance (Rrs) and oxygen saturation (SaO2) of arterial blood were continually measured. An average Rrs increase was 153% when compared to the initial values and it correlated with SaO2 decrease (5.5% of the initial values).

[Simultaneous recording of spirometric parameters and total respiratory resistance on the Astograph in nonspecific bronchial provocation tests using methacholine].

Parallel study results of spirometric parameters (S.P.) FEV1, FEF50, FEF25 and total respiratory resistance (Rrs) measured by Astograph in nonspecific metacholine bronchoprovocation test were analyzed in 378 patients suspected of bronchial asthma.

[Etiopathogenic mechanisms of increased airway responsiveness].

Views on mechanisms of increased airway responsiveness in patients with bronchial asthma and other respiratory tract are presented. The data have been divided into three parts: mucosal and submucosal changes, changes in airway regulations and effector cells. In the first part the etiopathological mechanisms of inflammatory processes in airways are explained.