LKB1 deficiency in skeletal muscle does not worsen obesity or insulin resistance in mice on a high-fat diet.
While body weight gain was unaffected, gene expression related to mitochondria, inflammation, and oxidative stress was heavily impacted by the absence of LKB1.
These findings indicate that LKB1 plays a key role in muscle metabolism, but its absence leads to altered protein degradation and inflammation without affecting overall glucose tolerance or body weight.