Publications by authors named "Tanmoy Samaddar"
The Ring Finger Protein 10 [RNF10] is a novel synapse-to-nucleus signaling protein that specifically links activation of synaptic NMDA receptors to modulation of gene expression. RNF10 dissociation from the GluN2A subunit of the NMDA receptor represents the first step of its synaptonuclear transport and it is followed by an importin-dependent translocation into the nucleus. Here, we have identified protein kinase C [PKC]-dependent phosphorylation of RNF10 Ser31 as a key step for RNF10 detachment from NMDA receptor and its subsequent trafficking to the nucleus.
View Article and Find Full Text PDFSynapses and nuclei are connected by bidirectional communication mechanisms that enable information transfer encoded by macromolecules. Here, we identified RNF10 as a novel synaptonuclear protein messenger. RNF10 is activated by calcium signals at the postsynaptic compartment and elicits discrete changes at the transcriptional level.
View Article and Find Full Text PDFArticle Synopsis
- The study explores how activity-dependent regulation of AMPA receptors (AMPARs) influences synaptic strength, particularly during brain development and in response to experiences.
- Researchers employed molecular techniques, including RNA interference and knock-out mouse models, to investigate the roles of two proteins, PSD-95 and SAP102, in managing AMPARs at synapses.
- Findings suggest that while PSD-95 and SAP102 interact to enhance AMPAR function, specific domains within PSD-95 are crucial for this regulation, highlighting the importance of protein structure in synaptic transmission processes.