Protective efficacy of fish oil nanoemulsion against non-typhoidal mediated mucosal inflammation and loss of barrier function.

Non-typhoidal serotypes are well adapted to utilize the inflammation for colonization in the mammalian gut mucosa and cause loss of the integrity of the epithelial barrier in the mammalian intestine. The present study assessed the protective efficacy of fish oil-in-water nanoemulsion, compared to the conventional emulsion, towards the intestinal epithelial barrier against invasive infection of serovar Typhimurium strain SL1344 in an streptomycin-treated mouse model. Non-typhoidal serovar Typhimurium strain SL1344 expresses its invasiveness by creating extreme inflammatory assault in the mammalian host lumen its repertoire of secretory or membrane-bound proteins.

Altered molecular attributes and antimicrobial resistance patterns of Vibrio cholerae O1 El Tor strains isolated from the cholera endemic regions of India.

Aims: The present study aimed to document the comparative analysis of differential hypervirulent features of Vibrio cholerae O1 strains isolated during 2018 from cholera endemic regions in Gujarat and Maharashtra (Western India) and West Bengal (Eastern India).

Methods And Results: A total of 87 V. cholerae O1 clinical strains from Western India and 48 from Eastern India were analysed for a number of biotypic and genotypic features followed by antimicrobial resistance (AMR) profile.

Antimicrobial loaded gum odina - gelatin based biomimetic spongy scaffold for accelerated wound healing with complete cutaneous texture.

The main objective of this study was to assess the therapeutic activity of gum odina and gelatin based biomimetic scaffold which was previously established as an excellent wound dressing material. In the accelerated stability study, the changes in physicochemical properties were found to be negligible. The cytotoxicity studies were carried out in-vitro and the results showed that upto 90% of the cells remained viable in presence of the scaffold, confirming its biocompatibility.

A Mouse Model of Helicobacter pylori Infection.

Infection with Helicobacter pylori (H. pylori) is of great distress because of its vital role in the pathogenesis of chronic gastritis, peptic ulcers, and in the multi-step carcinogenic process of gastric cancer. The increasing antibiotic resistance pattern of H.

Enzymatically excised oligopeptides from shows potent antioxidative and anti-hypertensive activity.

Abstract: an edible mollusca, serves as a protein rich food source for the tribes in India. The objective of the present study was to isolate the protein fraction of the edible foot part of for hydrolysis with three proteases, namely papain, pepsin, and alcalase. protein isolates and hydrolysates were characterised for the functional properties like protein solubility index, emulsifying property, foaming property.

Enzymatic synthesis of lipophilic lutein-PUFA esters and assessment of their stabilization potential in EPA-DHA rich fish oil matrix.

The objective of the present study was to synthesize ω-3 polyunsaturated fatty acid esters of lutein and to evaluate if esterification can stabilize the both bioactive molecules. Both ω-3 polyunsaturated fatty acid and lutein are prone towards auto-oxidation in their free form. Free lutein extracted from the marigold petals was enzymatically esterified using NS435 Lipase B, with the ω-3 long-chain polyunsaturated fatty acids.

Effects of nano-sizing on lipid bioaccessibility and ex vivo bioavailability from EPA-DHA rich oil in water nanoemulsion.

The physiological efficacy of nutraceuticals is dependent on their physicochemical nature and bioavailability across biological barriers. In the present work, effects of nano-sizing of emulsion-based delivery vehicle on the bioavailability of polyunsaturated fatty acids rich fish oil have been investigated via three-step experimental design; ex vivo rat everted intestinal sac model, cellular lipid uptake and the bioactivity in rat PBMCs. Nanoemulsion in comparison to the conventional emulsion has shown significant higher rate of uptake of polyunsaturated fatty acids in three segments of small intestine.

Treatment of cosmetic effluent in different configurations of ceramic UF membrane based bioreactor: Toxicity evaluation of the untreated and treated wastewater using catfish (Heteropneustes fossilis).

Extensive usage of pharmaceutical and personal care products (PPCPs) and their discharge through domestic sewage have been recently recognized as a new generation environmental concern which deserves more scientific attention over the classical environmental pollutants. The major issues of this type of effluent addressed in this study were its colour, triclosan and anionic surfactant (SDS) content. Samples of cosmetic effluent were collected from different beauty treatment salons and spas in and around Kolkata, India and treated in bioreactors containing a bacterial consortium isolated from activated sludge samples collected from a common effluent treatment plant.

Comparative prophylactic effects of α-eleostearic acid rich nano and conventional emulsions in induced diabetic rats.

The present work entailed perspicacious fabrication of Bitter Gourd Seed Oil Nanoemulsion (BGO-NE) for increasing bioavailability of CLnA in oxidative stress induced in vivo system. The BGO-NE was characterized and evaluated for dimensional as well as rheological changes periodically during a 12 week storage period. BGO comprising ∼50 % α-eleostearic acid, was assessed in conventional and NE formulation at different doses, for its ability to stimulate antioxidative enzyme marker paradigm comprising SOD, GPx, CAT and GSH, inherent to the subjects under study.

Application of isolated bacterial consortium in UMBR for detoxification of textile effluent: comparative analysis of resultant oxidative stress and genotoxicity in catfish (Heteropneustes fossilis) exposed to raw and treated effluents.

A bacterial consortium isolated from activated sludge was identified to be Bacillus sp., Pseudomonas sp., Shigella sp.