Publications by authors named "Tanja Weidlich"
Background: The immune response to COVID-19-vaccination differs between naïve vaccinees and those who were previously infected with SARS-CoV-2. Longitudinal quantitative and qualitative serological differences in these two distinct immunological subgroups in response to vaccination are currently not well studied.
Methods: We investigate a cohort of SARS-CoV-2-naïve and COVID-19-convalescent individuals immediately after vaccination and 6 months later.
Article Synopsis
- Omicron, a variant of SARS-CoV-2, shows significant mutations in the receptor-binding domain, which impacts antibody efficacy, especially with treatments like Casirivimab and Imdevimab.
- The variant's mutations have less effect on ACE2 binding and some antibodies, indicating a complex interaction between the virus and immune response.
- Despite booster vaccinations improving antibody levels, they still fall short compared to responses against the original Wuhan strain, highlighting Omicron's altered antigenicity and the potential effectiveness of certain antibodies in treatment.
Background: The long-term course of immunity among individuals with a history of COVID-19, in particular among those who received a booster vaccination, has not been well defined so far.
Methods: SARS-CoV-2-specific antibody levels were measured by ELISA over 1 year among 136 health care workers infected during the first COVID-19 wave and in a subgroup after booster vaccination approximately 1 year later. Furthermore, spike-protein-reactive memory T cells were quantified approximately 7 months after the infection and after booster vaccination.
Objective: To follow serological immune responses of front-line healthcare workers after PCR-confirmed COVID-19 for a mean of 30 weeks, describe the time-course of SARS-CoV-2 spike protein-specific IgG, IgA and IgM levels and to identify associations of the immune response with symptoms, demographic parameters and severity of disease.
Methods: Anti-SARS-CoV-2 S protein-specific IgG, IgA and IgM antibodies were measured at three time points during the 30-week follow-up. COVID-19-specific symptoms were assessed with standardized questionnaires.