Publications by authors named "Tanja Pilz"
Article Synopsis
- Nontyphoidal Salmonella (NTS) is a major cause of invasive infections among children under 5 in sub-Saharan Africa, with asymptomatic fecal shedding possibly facilitating human-to-human transmission, particularly in low-resource areas.
- This study involved 3,293 children and healthy individuals in Nairobi, revealing a 1.52% prevalence of NTS, and 31% of children with a previous NTS infection exhibited asymptomatic shedding post-treatment, with some shedding the same strain as during their illness.
- The findings suggest a likely connection between asymptomatic shedding and the transmission of NTS, supporting the idea that introducing a vaccine could help mitigate these infections in vulnerable populations.*
Unlabelled: Bacterial plasmids play a major role in the spread of antibiotic resistance genes. However, their characterization via DNA sequencing suffers from the low abundance of plasmid DNA in those samples. Although sample preparation methods can enrich the proportion of plasmid DNA before sequencing, these methods are expensive and laborious, and they might introduce a bias by enriching only for specific plasmid DNA sequences.
View Article and Find Full Text PDFBackgroundEmerging antimicrobial resistance (AMR) challenges gonorrhoea treatment and requires surveillance.AimThis observational study describes the genetic diversity of isolates in Germany from 2014 to 2017 and identifies multi-antigen sequence typing (NG-MAST) genogroups associated with AMR or some patient demographics.Methods1,220 gonococcal isolates underwent AMR testing and NG-MAST.
View Article and Find Full Text PDFPlatinum-based drugs, in particular cisplatin (cis-diamminedichloridoplatinum(II), CDDP), are used for treatment of squamous cell carcinoma of the head and neck (SCCHN). Despite initial responses, CDDP treatment often results in chemoresistance, leading to therapeutic failure. The role of primary resistance at subclonal level and treatment-induced clonal selection in the development of CDDP resistance remains unknown.
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