Publications by authors named "Tanja Klause"
Article Synopsis
- The innate immune system plays a vital role in managing infections but can also lead to disease, particularly in the context of Listeria monocytogenes, a foodborne pathogen that lacks sufficient understanding in its interaction with host immunity.
- Researchers found that Listeria DNA is packaged into extracellular vesicles (EVs) within infected cells and released to surrounding cells, activating the cGAS-STING signaling pathway, which helps the immune response.
- The study identified the protein MVB12b, essential for the sorting of bacterial DNA into EVs, and noted that EVs from Listeria-infected cells can inhibit T-cell proliferation and promote apoptosis, suggesting a mechanism by which
During Coxsackievirus B3 (CVB3) infection hepatitis is a potentially life threatening complication, particularly in newborns. Studies with type I interferon (IFN-I) receptor (IFNAR)-deficient mice revealed a key role of the IFN-I axis in the protection against CVB3 infection, whereas the source of IFN-I and cell types that have to be IFNAR triggered in order to promote survival are still unknown. We found that CVB3 infected IFN-β reporter mice showed effective reporter induction, especially in hepatocytes and only to a minor extent in liver-resident macrophages.
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