[A case experienced long-term survival after repeat hepatectomy for liver metastases from gastric cancer].

Although the standard treatment for liver metastasis from gastric cancer is chemotherapy, there are several reports demonstrating better survival after hepatectomy. However, repeat hepatectomy for liver metastasis is still rare. We present a case of long-term survival after repeat hepatectomy for liver metastasis from gastric cancer.

[Conversion therapy of stage IV gastric cancer].

Aim: Patients with Stage IV gastric cancer are currently not considered operative candidates and are most often offered systemic chemotherapy. Recently, several novel regimens of combined chemotherapy have occasionally converted an initially unresectable gastric cancer to a resectable status. We evaluated the efficacy of surgical resection following the response to the primary chemotherapy for Stage IV gastric cancer.

Human myo-inositol monophosphatase 2 rescues the nematode thermotaxis mutant ttx-7 more efficiently than IMPA1: functional and evolutionary considerations of the two mammalian myo-inositol monophosphatase genes.

Mammals express two myo-inositol monophosphatase (IMPase) genes, IMPA1/Impa1 and IMPA2/Impa2. In this study, we compared the spatial expression patterns of the two IMPase gene transcripts and proteins in mouse tissues. Results indicated discrete expression of the two IMPase genes and their protein products in various organs, including the brain.

H2DB: a heritability database across multiple species by annotating trait-associated genomic loci.

H2DB (http://tga.nig.ac.

Value of splenectomy in patients with Siewert type II adenocarcinoma of the esophagogastric junction.

Background: The incidence of adenocarcinoma of the esophagogastric junction (AEG) has been increasing recently in both Western and Eastern countries. However, an optimal treatment strategy for Siewert type II AEG is still unclear. The aim of this study was to clarify the value of splenectomy in patients with Siewert type II AEG.

The impact of preoperative lymph node size on long-term outcome following curative gastrectomy for gastric cancer.

Background: Multidetector-row computed tomography (MDCT) is widely used to predict pathological nodal status. However, an appropriate nodal size cutoff value to predict pathological nodal status has not been determined, and the impact of preoperative lymph node size on long-term outcomes is unclear.

Methods: This study included 137 gastric cancer patients with nodal involvement who underwent R0 gastrectomy between September 2002 and December 2006.

Poor survival rate in patients with postoperative intra-abdominal infectious complications following curative gastrectomy for gastric cancer.

Background: The impact of postoperative complications on recurrence rate and long-term outcome has been reported in patients with colorectal and esophageal cancer, but not in patients with gastric cancer. This study evaluated the impact of postoperative intra-abdominal infectious complications on long-term survival following curative gastrectomy.

Methods: This study included 765 patients who underwent curative gastrectomy for gastric cancer between 2002 and 2006.

[A case of pathological complete response after chemotherapy for liver metastasis with subcapsular hemorrhage from gastric cancer:].

A57 years old man with gastric cancer underwent distal gastrectomy (pT3N1M0, pStage II B). Three months after gastric resection, he was admitted to our hospital because of acute right dorsal pain. Abdominal computed tomography showed multiple liver tumors with subcapsular hemorrhage.

Postoperative intra-abdominal complications assessed by the Clavien-Dindo classification following open and laparoscopy-assisted distal gastrectomy for early gastric cancer.

Background: Laparoscopy-assisted gastrectomy (LAG) has been increasingly used for the treatment of early gastric cancer, and many advantages over open gastrectomy (OG) have been reported. However, only a few reports have assessed postoperative complications following LAG using the Clavien-Dindo classification.

Methods: A total of 265 patients who underwent distal gastrectomy or pylorus-preserving gastrectomy with D1+ lymph node dissection for clinical stage IA early gastric cancer at the Shizuoka Cancer Center between June 2009 and December 2011 were included in this study.

Survival benefit of palliative gastrectomy in gastric cancer patients with peritoneal metastasis.

Background: The survival benefit of palliative gastrectomy in patients with peritoneal metastasis as a single incurable factor remains unclear.

Methods: A total of 148 gastric cancer patients with peritoneal metastasis underwent gastrectomy or chemotherapy at the Shizuoka Cancer Center between September 2002 and December 2008 and were included in this study. The effects of gastrectomy and chemotherapy on their long-term outcome were investigated.

Impact of esophageal invasion on clinicopathological characteristics and long-term outcome of adenocarcinoma of the subcardia.

Backgrounds And Objectives: A different classification system was used in the 7th edition of the TNM classification for adenocarcinoma of the subcardia either with or without esophageal invasion. The aim of this study was to clarify the clinicopathological and survival impact of esophageal invasion.

Methods: The present study included 351 patients who underwent gastrectomy for adenocarcinoma located within 5 cm of the esophagogastric junction.

Influenza viral load and rapid influenza diagnostic tests in children and adults.

We compared children and adults with regard to rapid influenza test sensitivity and viral load. Specimen volumes were measured, rapid tests were conducted, and viral load was determined. There was no difference between children and adults in test sensitivity or viral load, but children had higher specimen volumes.

Synaptic polarity depends on phosphatidylinositol signaling regulated by myo-inositol monophosphatase in Caenorhabditis elegans.

Although neurons are highly polarized, how neuronal polarity is generated remains poorly understood. An evolutionarily conserved inositol-producing enzyme myo-inositol monophosphatase (IMPase) is essential for polarized localization of synaptic molecules in Caenorhabditis elegans and can be inhibited by lithium, a drug for bipolar disorder. The synaptic defect of IMPase mutants causes defects in sensory behaviors including thermotaxis.

Meat intake frequency and anemia in Japanese children and adolescents.

The consumption of meat products is considered to be a feasible solution to prevent anemia, which is a critical health problem. The present study assessed hematological parameters and the prevalence of anemia in Japanese children and adolescents, and examined the association with the frequency of meat intake. Data from the Shunan Children Health Cohort Study were analyzed.

Intra-abdominal infectious complications following gastrectomy in patients with excessive visceral fat.

Background: Excessive visceral fat may be a better predictor of the development of postoperative morbidity after gastrectomy than body mass index (BMI). The aim of the present study was to clarify the most appropriate fat parameter to predict pancreas-related infection and anastomotic leakage following gastrectomy.

Methods: The study was performed in 206 patients who underwent curative gastrectomy at the Shizuoka Cancer Center between April 2008 and March 2009.

Evaluation of postoperative pancreatic fistula after total gastrectomy with D2 lymphadenectomy by ISGPF classification.

Introduction: Postoperative pancreatic fistula (POPF) is a serious complication of total gastrectomy (TG) with D2 lymphadenectomy (D2). However, the actual incidence and risk factors are not yet completely understood, due in part to the absence of the widely accepted criteria for POPF following gastrectomy.

Patients And Methods: One hundred and four patients who underwent TG with D2 between March 2007 and December 2009 were included in this study.

Hematopoietic progenitor cell count, but not immature platelet fraction value, predicts successful harvest of autologous peripheral blood stem cells.

Mobilized stem cells in the peripheral blood (PB) must be efficiently harvested at the appropriate time before autologous PB stem cell (PBSC) transplantation. Enumeration of CD34+ cells in the PB before apheresis predicts the number of PBSCs that can be collected, but the cytometric techniques used are complex and expensive. Therefore, it is necessary to identify an alternative to the CD34+ cell count in PBSC harvest-time monitoring.

[Incretin enhancer: sitagliptin].

Recently, incretin-based therapies have become available for patients with type 2 diabetes in Japan. Sitagliptin is one of several DPP-4 inhibitors. After an OGTT, active endogenous GLP-1 concentrations are increased about twofold by sitagliptin.

Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation.

Background: The combination of elevated glucose and free-fatty acids (FFA), prevalent in diabetes, has been suggested to be a major contributor to pancreatic β-cell death. This study examines the synergistic effects of glucose and FFA on β-cell apoptosis and the molecular mechanisms involved. Mouse insulinoma cells and primary islets were treated with palmitate at increasing glucose and effects on apoptosis, endoplasmic reticulum (ER) stress and insulin receptor substrate (IRS) signaling were examined.