Publications by authors named "Tanisha Teelucksingh"
Article Synopsis
- Widespread sequencing has identified thousands of missense variants linked to diseases, creating a challenge in assessing their functional impact at scale.
- A new high-throughput imaging platform was developed to evaluate the effects of 3,448 missense variants across over 1,000 genes, revealing that mislocalization of proteins is a frequent outcome.
- Mislocalization affects about one-sixth of pathogenic variants and is mainly caused by issues with protein stability and membrane insertion, which can influence disease severity and help interpret uncertain variants.
Klebsiella pneumoniae is a leading cause of nosocomial infections, including pneumonia, bacteremia, and urinary tract infections. Treatment options are increasingly restricted by the high prevalence of resistance to frontline antibiotics, including carbapenems, and the recently identified plasmid-conferred colistin resistance. The classical pathotype (cKp) is responsible for most of the nosocomial infections observed globally, and these isolates are often multidrug resistant.
View Article and Find Full Text PDFEfflux pumps are a serious challenge for the development of antibacterial agents. Overcoming efflux requires an in-depth understanding of efflux pump functions, specificities and the development of inhibitors. However, the complexities of efflux networks have limited such studies.
View Article and Find Full Text PDFBacteria harness an impressive repertoire of resistance mechanisms to evade the inhibitory action of antibiotics. One such mechanism involves efflux pump-mediated extrusion of drugs from the bacterial cell, which significantly contributes to multidrug resistance. Intriguingly, most drug efflux pumps are chromosomally encoded components of the intrinsic antibiotic resistome.
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