T3SS effector EseN is a phosphothreonine lyase that inactivates ERK1/2, p38, JNK, and PDK1 and modulates cell death in infected macrophages.

This work has global significance in the catfish industry, which provides food for increasing global populations. is a leading cause of disease loss, and EseN is an important player in virulence. The T3SS effector EseN plays an essential role in establishing infection, but the specific role EseN plays is not well characterized.