Publications by authors named "Tanis Hogg"
Drug conjugates have become a significant focus of research in the field of targeted medicine for cancer treatments. Peptide-drug conjugates (PDCs), a subset of drug conjugates, are composed of carrier peptides ranging from 5 to 30 amino acid residues, toxic payloads, and linkers that connect the payload to the peptide. PDCs are further broken down into cell-penetrating peptides (CPPs) and cell-targeting peptides (CTPs), each having their own differences in the delivery of cytotoxic payloads.
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- - Pokeweed antiviral protein (PAP) is a type I ribosome-inactivating protein that has antibacterial, antifungal, and antiviral properties, primarily by targeting ribosomal RNA in both viruses and eukaryotic cells.
- - The study focused on the cytotoxicity of PAP isoenzymes isolated from seeds of Asian pokeweed, employing techniques like protein sequencing and X-ray crystallography to analyze the structure of PAP‑S1aci, which closely resembles another variant from P. americana.
- - Notable findings included a proline substitution that doesn't affect function but alters the geometry of the protein, and minimal N-glycosylation that is believed to enhance cytotoxic properties by preventing interference with rRNA-binding
Malaria is caused by protozoan erythrocytic parasites of the Plasmodium genus, with Plasmodium falciparum being the most dangerous and widespread disease-causing species. Falcipain-2 (FP-2) of P. falciparum is a papain-family (C1A) cysteine protease that plays an important role in the parasite life cycle by degrading erythrocyte proteins, most notably hemoglobin.
View Article and Find Full Text PDFEnzymes of the Rel/Spo family enable bacteria to survive prolonged periods of nutrient limitation by producing an intracellular signaling alarmone, (p)ppGpp, which triggers the so-called stringent response. Both the synthesis of (p)ppGpp from ATP and GDP(GTP), and its hydrolysis to GDP(GTP) and pyrophosphate, are catalyzed by Rel/Spo proteins. The 2.
View Article and Find Full Text PDFSugar-mediated lattice contacts in crystals of a plant glycoprotein.
Acta Crystallogr D Biol Crystallogr
October 2002
Pokeweed antiviral protein, PAP-S(aci), isolated from seeds of the Chinese pokeweed plant, Phytolacca acinosa, belongs to the family of type-1 ribosome-inactivating proteins (RIPs). Type-1 RIPs are approximately 30-kDa N-glycosidases that inactivate eukaryotic and prokaryotic ribosomes via a site-specific depurination of ribosomal RNA (rRNA). Here we describe the preliminary X-ray structure determination at 1.
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