Relation of peritubular capillary features to class of lupus nephritis.

Background: Experimental studies have linked peritubular capillary (PTC) loss with progression of chronic kidney disease. Minimal information on PTC in lupus nephritis (LN) has been reported. We therefore evaluated the PTC area in different classes of LN and determined if specific clinical characteristics correlated with PTC changes.

Monosodium glutamate (MSG) consumption is associated with urolithiasis and urinary tract obstruction in rats.

Background: The peritoneal injection of monosodium glutamate (MSG) can induce kidney injury in adult rats but the effects of long-term oral intake have not been determined.

Methods: We investigated the kidney histology and function in adult male Wistar rats that were fed ad libitum with a standard rat chow pellet and water with or without the addition of 2 mg/g body weight MSG/day in drinking water (n=10 per group). Both MSG-treated and control animals were sacrificed after 9 months when renal function parameters, blood and urine electrolytes, and tissue histopathology were determined.

High expression of ABCC1 indicates poor prognosis in intrahepatic cholangiocarcinoma.

Intrahepatic cholangiocarcinoma (ICC) is a serious health problem in Thailand. To reach a cure, radical resection is the gold standard but most patients are not candidates because of delayed first presentation. Palliative surgery and/or combined chemotherapy are alternatives; however, outcomes are still unsatisfactory.