The psychometric properties of the Depression Anxiety Stress Scale-21 (DASS-21) Bangla version.

The Bangla version of the Depression Anxiety Stress Scale-21 (DASS-21-BV) draws huge attention among the researchers to assess the mental health status in various situations among the Bangladeshi adults. Since no published research article to date has assessed the psychometric properties of the scale (Bangla version), this study (n = 980 Bangladeshi adults) aimed to assess the psychometric characteristics of this scale utilizing both classical test theory (CTT) and item response theory (IRT) approaches. Item analysis results (item-total correlations in CTT and slope coefficients of the graded response model in IRT) suggested that items had satisfactory discrimination indices.

In silico analysis of deleterious SNPs of human MTUS1 gene and their impacts on subsequent protein structure and function.

The mitochondrial tumor suppressor 1 (MTUS1) gene acts as a crucial tumor suppressor by inhibiting growth and proliferation of eukaryotic cells including tumor cell lines. Down regulation of MTUS1 gene has been implicated in a wide range of cancers as well as various human diseases. Alteration through nsSNPs can potentially damage the structure and/or function of the protein.

Mental Health Status, Anxiety, and Depression Levels of Bangladeshi University Students During the COVID-19 Pandemic.

The current COVID-19 pandemic has affected people of all ages across the world both physically and psychologically. Understanding COVID-19's impact on university students' mental health status in Bangladesh has been limited, yet is a necessary population to study, since they are particularly vulnerable to stress and mental health issues. This study assessed anxiety, depressive symptoms, and mental health status among university students in Bangladesh.

Replication analysis of the COVID-19 Worry Scale.

Efforts and focus regarding the COVID-19 pandemic have largely been centered around physical health. However, mental health is equally as critical-as such, psychological impacts can resonate adversely during and following the pandemic. This study examined a sample of 729 Bangladeshi people and aimed to assess the psychological impact of the pandemic.

Adaptation of the Bangla Version of the COVID-19 Anxiety Scale.

The Coronavirus Anxiety Scale (CAS) is among the first few published screening tools for assessing dysfunctional anxiety induced by the current COVID-19 pandemic. The CAS was translated into the Bangla language following the International Test Commission's guidelines for this adaptation study and placed in an online survey ( = 737, with a mean age of 26.55 ( = 7.

Effect of non-synonymous SNP on JAK1 protein structure and subsequent function.

JAK1 gene plays a critical role in signalling. Malfunction of JAK1 is linked to numerous human diseases ranging from chronic inflammation to cancers and autoimmune diseases. Genetic variations in JAK1 exhibit deleterious effects on gene function leading to the deregulation of signalling pathways.