Real-Time Total Content Uniformity Assessment of Solid Dosage Forms Using Near-Infrared Transmission Spectroscopy.

Real-time monitoring of solid dosage forms is crucial in continuous manufacturing processes for detecting product variability and bias and minimizing defective products. Traditional process analytical technologies often struggle to maintain high-throughput production. This study presents a novel approach using near-infrared (NIR) transmission spectroscopy for rapidly and comprehensively assessing the quality of solid dosage forms.

Mitochondrial phylogeny and distribution of cytoplasmic male sterility-associated genes in Beta vulgaris.

Cytoplasmic male sterility (CMS) is a mitochondrial-encoded trait that confers reproductive defects in males but not in females or any vegetative function. Why CMS is so often found in plants should be investigated from the viewpoint of mitochondrial phylogeny. Beta vulgaris, including the wild subspecies maritima and cultivated subspecies vulgaris (e.

Human milk-specific fat components enhance the secretion of ghrelin by MGN3-1 cells.

Triacylglycerols (TAGs) are a major fat component in human milk. Since gastric lipase produces 1,2-diacylglycerol from TAGs, we focused on the bioactivity of human milk-derived diacylglycerols in stomach cells. Ghrelin is produced in the stomach and acts as an important regulator of growth hormone secretion and energy homeostasis.

Nuclear DNA segments homologous to mitochondrial DNA are obstacles for detecting heteroplasmy in sugar beet (Beta vulgaris L.).

Heteroplasmy, the coexistence of multiple mitochondrial DNA (mtDNA) sequences in a cell, is well documented in plants. Next-generation sequencing technology (NGS) has made it feasible to sequence entire genomes. Thus, NGS has the potential to detect heteroplasmy; however, the methods and pitfalls in heteroplasmy detection have not been fully investigated and identified.

salivary gland extract alleviates acute itching by blocking TRPA1 channels.

() saliva induces a variety of anti-inflammatory and immunomodulatory activities. Interestingly, although it is known that mosquito bites cause allergic reactions in sensitised hosts, the primary exposure of humans to does not evoke significant itching. Whether active components in the saliva of can counteract the normal itch reaction to injury produced by a histaminergic or non-histaminergic pathway in vertebrate hosts is unknown.

Vascular parameters and endothelin-1 measurements in glaucoma patients with low- and high-tension optic disc hemorrhages.

This prospective study aimed to compare vascular parameters (endothelin-1 [ET-1] blood levels, laser Doppler imaging [LDI] of distal phalanxes, and nailfold capillaroscopy) between open-angle glaucoma patients with low- and high-tension optic disc hemorrhages (LTDH and HTDH, respectively). The 33 enrolled patients (mean age, 62.3 ± 13 years) were classified as LTDH or HTDH if they presented at the time of DH detection an intraocular pressure (IOP) < 16 mmHg or ≥ 16 mmHg, respectively.

Analgesic efficacy of modified thoracoabdominal nerves block through the perichondrial approach in laparoscopic cholecystectomy: A retrospective study with propensity analysis.

Modified thoracoabdominal nerves block through the perichondral approach (M-TAPA) was recently reported to provide broad analgesia with only a single injection of local anesthetics (LA) on each side. However, the effectiveness of M-TAPA in laparoscopic cholecystectomy (LC) is not often reported. We retrospectively evaluated the analgesic efficacy of M-TAPA in patients who underwent LC and compared it with conventional LA infiltration (LAI) by calculating the propensity score.

Rice Endoplasmic Protein-Derived Peptides, Rice-Ghretropins A and B, Stimulate Ghrelin Release in MGN3-1 Cells and Increase Plasma Acylated Ghrelin and Food Intake in Mice.

In this study, we demonstrated that novel rice-derived bioactive peptides promote the secretion of ghrelin, an endogenous orexigenic hormone secreted from the stomach. The enzymatic digest of rice endosperm protein with subtilisin, a microorganism-derived enzyme, stimulated acylated ghrelin secretion in the ghrelin-releasing cell line MGN3-1 and increased food intake after oral administration in mice. By performing a comprehensive analysis based on structure-activity relationships, we selected candidate peptides from over 30,000 peptides in the rice digest.

Peripheral Microvascular Abnormalities Associated with Open-Angle Glaucoma.

Purpose: To investigate peripheral microvascular abnormalities associated with patients with open-angle glaucoma (OAG).

Design: This was a cross-sectional study.

Participants: Patients with OAG and controls.

A Retrospective Chart Review of Factors Impacting Psychotropic Prescribing Patterns and Polypharmacy Rates in Youth with Autism Spectrum Disorder during the COVID-19 Pandemic.

High but variable rates of psychotropic polypharmacy (PP) in youth with autism spectrum disorder (ASD) have been reported in previous studies. The effect of the COVID-19 pandemic on prescribing patterns has not been well described. This study aims to examine the factors associated with psychotropic prescribing patterns, including rates of PP and multiclass polypharmacy (MPP) in youth with ASD during the COVID-19 pandemic.

Temporal patterns of increased growth hormone secretion in mice after oral administration of L-ornithine: possible involvement of ghrelin receptors.

l-Ornithine is known to stimulate growth hormone (GH) release in mammals. Here, we demonstrated that increases in plasma GH levels after oral administration of l-ornithine were first observed 150 min after administration, and the elevated levels were sustained for more than 90 min in mice. The increase was significantly delayed compared with the reported timing of plasma and tissue levels of l-ornithine after administration.

Year-round dynamics of amplicon sequence variant communities differ among eukaryotes, Imitervirales and prokaryotes in a coastal ecosystem.

Coastal microbial communities are affected by seasonal environmental change, biotic interactions and fluctuating nutrient availability. We investigated the seasonal dynamics of communities of eukaryotes, a major group of double-stranded DNA viruses that infect eukaryotes (order Imitervirales; phylum Nucleocytoviricota), and prokaryotes in the Uranouchi Inlet, Kochi, Japan. We performed metabarcoding using ribosomal RNA genes and viral polB genes as markers in 43 seawater samples collected over 20 months.

Structural abnormalities associated with glaucoma using swept-source optical coherence tomography in patients with systemic sclerosis.

Purpose: Vasospasm represents an early event in systemic sclerosis (SSc). Ocular vasospasm may induce optic nerve head (ONH) damage and has been involved in the pathogenesis of glaucoma, especially normal-tension glaucoma (NTG). We aimed to investigate the presence of structural abnormalities associated with NTG using swept-source optical coherence tomography (SS-OCT) and to correlate the OCT parameters with clinical, capillaroscopy and digital blood flow measures in patients with SSc.

College students' mental illness disclosure and self-esteem: a moderating role of self-image goals.

A link between the disclosure of a concealable stigma such as mental illness and enhanced psychological well-being tends to be weak and sometimes non-significant, pointing to the importance of examining potential moderators. This study aims to examine how self-image goals moderate the effect of mental illness disclosure on self-esteem. College students who self-identified as having been diagnosed with mental illness ( = 174) completed an online survey regarding their mental illness disclosure, self-image goals, and self-esteem.

Mental illness self-disclosure among college students: a pre-requisite of social support or a booster of social support benefits?

Background: Self-disclosing a concealable stigmatized identity (CSI) such as mental illness is generally associated with enhanced psychological well-being. Research also supports the link between social support and psychological well-being. Yet, few theoretical explanations exist for the role that mental illness disclosure plays in the association between social support PWB.

Photoperiodic changes in hippocampal neurogenesis and plasma metabolomic profiles in relation to depression-like behavior in mice.

Photoperiod alters affective behaviors and brain neuroplasticity in several mammalian species. We addressed whether neurogenesis and signaling pathways of insulin-like growth factor-I (IGF-I), a key modulator of neuroplasticity, are regulated by photoperiod in C57BL/6 J mice, a putative model of seasonal affective disorder. We also examined the effects of photoperiod on plasma metabolomic profiles in relation to depression-like behavior to understand a possible linkage between peripheral metabolism and behavior.

Are one's attachment avoidance toward a particular person and his/her placement of this particular person in the attachment hierarchy inversely overlapping? Four bifactor-analysis studies.

Do one's hierarchical preference for attachment support from a particular person over other people (attachment hierarchy) and his/her discomfort with closeness and uneasiness about being dependent on that particular person (attachment avoidance) inversely overlap? These two constructs have been distinctly conceptualized. Attachment hierarchy has been regarded as a normative characteristic of attachment relationships, while attachment avoidance has been considered to reflect an individual difference of relationship quality. Employing bifactor analyses, we demonstrated a unidimensional general factor of these two concepts in four studies exploring Czech young adults' relationships with mother, father, friends, and romantic partner (Study 1); U.

Intrinsic Optical Properties of Boston Keratoprosthesis.

Purpose: To benchmark the optical performance of Boston Keratoprosthesis (B-KPro).

Methods: Back focal lengths (BFL) of B-KPros for various eye axial lengths were measured using an optical bench, International Organization for Standardization-certified for intraocular lens characterization, and compared against manufacturer's specification. The modulation transfer function (MTF) and the resolution efficiencies were measured.

Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 3: Structure-activity relationships of pyrropyrazolone derivatives.

The P2X3 receptor is an attractive target for the treatment of pain and chronic coughing, and thus P2X3 antagonists have been developed as new therapeutic drugs. We previously reported selective P2X3 receptor antagonists by derivatization of hit compound 1. As a result, we identified hit compound 3, the structure of which was similar to hit compound 1.

Characterization of Prelaminar Wedge-Shaped Defects in Primary Open-Angle Glaucoma.

Purpose: To determine the clinical relevance of prelaminar wedge defects (PLWDs) detected by swept-source optical coherence tomography (SS-OCT) in primary open-angle glaucoma (POAG).

Materials And Methods: In this retrospective case-control study, PLWDs were defined as triangular-shaped defects at the surface of the optic nerve prelaminar tissue, not adjacent to blood vessels, present on cross-sectional SS-OCT scans. Two observers masked to diagnosis independently reviewed scans to detect PLWDs and lamina cribrosa defects.

The roles of mental illness disclosure and disclosure strategies on well-being among college students.

To examine how the degree of mental illness disclosure and disclosure strategies are associated with psychological and physical well-being among college students. : Participants were 181 undergraduate students from two American universities who self-identified as having been diagnosed with mental illness. Participants completed an online survey, which included measures of mental illness disclosure and a range of outcome measures (e.

Angle Anatomy and Glaucoma in Patients With Boston Keratoprosthesis.

Purpose: To quantitatively analyze the angle anatomy in eyes with a Boston type 1 keratoprosthesis (KPro) using anterior segment optical coherence tomography (AS-OCT) and to assess the diagnostic ability of AS-OCT in KPro-associated glaucoma.

Methods: AS-OCT (RTVue) images from KPro eyes with and without glaucoma were reviewed. The angle opening distance at 500 μm from the scleral spur (AOD500), trabecular-iris angle at 500 μm from the scleral spur (TIA500), and trabecular-iris surface area at 500 μm from the scleral spur (TISA500) were measured by 2 observers masked to the diagnosis.

Role of parental confirmation in body dissatisfaction and body change behaviors among college men.

To examine how the components of confirmation (i.e., acceptance and challenge) from mother and father have an indirect effect on college men's body dissatisfaction through self-concept, and if body dissatisfaction, in turn, is related to body change behaviors.

Muscle Talk Online and Impression Formation Based on Body Type: Comparisons Between Asian American and Caucasian American Males.

This study aimed to investigate how individuals form impressions about the self-esteem and life satisfaction of a male who engages in muscle talk on Facebook. The study examined (a) how a target's body build and peer-generated comments influence observers' impression of him, and (b) how such influences might be moderated by the cultural backgrounds of observers (Asian Americans and European Americans). A mock-up Facebook profile page was created in which two factors were manipulated: the target's body build (muscular, average, and overweight) and peer-generated messages (muscle encouraging and muscle discouraging), creating six different conditions.