Publications by authors named "Taniela Marli Bes"
Video-observed therapy (VOT) vs directly observed therapy (DOT) for tuberculosis treatment: A systematic review on adherence, cost of treatment observation, time spent observing treatment and patient satisfaction.
PLoS Negl Trop Dis
October 2024
Article Synopsis
- Tuberculosis treatment relies on strict adherence to medication regimens, with practices like Directly Observed Therapy (DOT) facing challenges, leading to the exploration of Video-Observed Therapy (VOT) as a promising alternative involving remote coaching via video calls.
- The review aims to evaluate VOT's effectiveness against DOT by assessing key factors like adherence, treatment costs, supervision time, and patient satisfaction, through systematic analysis of relevant studies.
- Results indicate that VOT is as effective as DOT in ensuring patient adherence, and it also lowers costs in scenarios where cost comparisons were made.
Infections caused by multidrug-resistant are a worldwide health concern with high mortality rates. Rapid identification of this infectious agent is critical as it can easily spread with difficult or no options for treatment. In this context, the development of reliable and economically viable detection and therapeutic methodologies are still challenging.
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- The study investigates the transfer of a resistance gene, qacA, from methicillin-resistant Staphylococcus aureus (MRSA) to Escherichia coli C600 via conjugative plasmids, which is not well understood in Gram-positive to Gram-negative bacteria.* -
- Through experiments, they successfully showed that MRSA can transfer chlorhexidine resistance to E. coli, significantly increasing the latter's resistance levels after the transfer.* -
- This research represents the first documented instance of the specific plasmid p_8N_qac carrying qacA being transferred to E. coli, highlighting concerns about the spread of resistance genes and the need for better antiseptic use.*
Chagas cardiomyopathy (ChCM) is a severe consequence of Trypanosoma cruzi infection and has a range of electrocardiographic (ECG) and echocardiographic (ECHO) manifestations. There is a need for a standard and parsimonious research cardiac end point that does not rely on expert panel adjudication, and it is not intended to change the ChCM definition. We use data from the REDS-II cohort to propose a simplified cardiac endpoint.
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- The study investigates the effectiveness of chlorhexidine (CHX) against methicillin-resistant Staphylococcus aureus (MRSA) in clinical isolates from a Brazilian hospital over a span of 11 years.
- A total of 216 MRSA isolates were analyzed for susceptibility to CHX and mupirocin, revealing resistance linked to specific genetic markers, including the qacA and mupA genes.
- The findings highlight the risk of spreading resistance to mupirocin within the hospital, emphasizing the need for ongoing monitoring and effective infection control measures.
Staphylococcus aureus (SA) is a commensal habitant of nasal cavities and skin. Colonization by community-acquired methicillin-resistant SA (CA-MRSA) is associated with infections in patients who have not been recently hospitalized. The aim of this study is to determine the prevalence of MRSA colonization in an outpatient population, currently unknown in Brazil.
View Article and Find Full Text PDFCan marine mammals be a reliable source for the manufacture of prosthetic heart valves for percutaneous surgery?
J Long Term Eff Med Implants
August 2013
Marine mammals experience unique physiological conditions when diving. Myocardial function is sustained despite a 90% reduction of the blood flow in the coronaries. Therefore, their heart valves and pericardium could serve as a unique source of tissue for the manufacture of prosthetic heart valves.
View Article and Find Full Text PDFA failing mitral valve prosthesis made from bovine pericardium was explanted from a 50-year-old patient. Preoperative transthoracic-echocardiography had confirmed severe mitral regurgitation due to structural failure of this HP Bio bovine pericardium heart valve prosthesis. The explanted device was examined macroscopically, by scanning electron microscopy (SEM), by light microscopy, and by transmission electron microscopy (TEM).
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