Publications by authors named "Tania de Souza Brum"
Changes in the NK Cell Repertoire Related to Initiation of TB Treatment and Onset of Immune Reconstitution Inflammatory Syndrome in TB/HIV Co-infected Patients in Rio de Janeiro, Brazil-ANRS 12274.
Carmem Beatriz Wagner Giacoia-Gripp Andressa da Silva Cazote Tatiana Pereira da Silva Flávia Marinho Sant'Anna Carolina Arana Stanis Schmaltz Tania de Souza Brum
Front Immunol
September 2020
Article Synopsis
- Tuberculosis (TB) is a major health issue for individuals with HIV, being the leading cause of death, but combined antiretroviral therapy (cART) can help improve survival, despite issues like immune reconstitution inflammatory syndrome (IRIS).
- The study evaluated various types of innate lymphocytes in TB/HIV patients, including natural killer (NK) and γδ T cells, using flow cytometry, comparing them to patients with only TB or HIV and healthy controls.
- Findings showed significant changes in NK cell activation markers in TB/HIV patients, particularly those with IRIS, and highlighted an increased presence of certain γδ T cell subsets, indicating that HIV affects immune cell populations and responses during TB treatment.