Identification and Prioritization of Canadian Society of Nephrology Clinical Practice Guideline Topics.

Introduction: Nephrology clinical practice guideline topics are routinely determined by clinicians and researchers, without extensive engagement of people with lived experience (PWLE) of kidney disease and their caregivers. The Canadian Society of Nephrology (CSN) Clinical Practice Guidelines Committee (CPGC) completed this modified Delphi study to incorporate diverse stakeholder perspectives in identifying and prioritizing future guideline topics.

Methods: We recruited nephrology clinicians, researchers, PWLE of kidney disease or their caregivers for this study.

Identification and Prioritization of Canadian Society of Nephrology Clinical Practice Guideline Topics With Multidisciplinary Stakeholders and People Living With Kidney Disease: A Clinical Research Protocol.

Background: Despite efforts to provide evidence-based care for people living with kidney disease, health care provider goals and priorities are often misaligned with those of individuals with lived experience of disease. Coupled with competing interests of time, resources, and an abundance of suitable guideline topics, identifying and prioritizing areas of focus for the Canadian nephrology community with a patient-oriented perspective is necessary and important. Similar priority-setting exercises have been undertaken to establish research priorities for kidney disease and to standardize outcomes for kidney disease research and clinical care; however, research priorities are distinct from priorities for guideline development.

Precision Medicine in Diabetic Kidney Disease: A Narrative Review Framed by Lived Experience.

Purpose Of Review: Diabetic kidney disease (DKD) is a leading cause of chronic kidney disease (CKD) for which many treatments exist that have been shown to prevent CKD progression and kidney failure. However, DKD is a complex and heterogeneous etiology of CKD with a spectrum of phenotypes and disease trajectories. In this narrative review, we discuss precision medicine approaches to DKD, including genomics, metabolomics, proteomics, and their potential role in the management of diabetes mellitus and DKD.