Insight into the antifungals used to address human infection due to spp.: a scoping review.

Trichosporonosis infections have been increasing worldwide. Providing adequate treatment for these infections remains a challenge. This scoping review contains information about potential antifungals to treat this pathology.

Targeting Candida spp. to develop antifungal agents.

Invasive fungal infections are a complex challenge throughout the world because of their high incidence, mainly in critically ill patients, and high mortality rates. The antifungal agents currently available are limited; thus, there is a need for the rapid development of new drugs. In silico methods are a modern strategy to explore interactions between new compounds and specific fungal targets, but they depend on precise genetic information.

Diagnosis and management of a fatal case of sepsis caused by in a neonate with omphalocele.

We present a fatal case of persistent neonatal candidemia by following omphalocele, without other anomalies. Despite an encouraging initial prognosis, after surgical correction and closure of the abdominal wall the case became difficult to treat, as in addition to the exposure of the patient to multiple risk factors for candidemia, antifungal therapy apparently was not adequate.

A new small-molecule KRE2 inhibitor against invasive Candida parapsilosis infection.

Aim: To investigate the antifungal activity of MOL3, a small molecule that was selected by virtual screening, against Candida spp.

Materials & Methods: The antifungal activity of MOL3 was evaluated using standard strains and clinical isolates. Activity was evaluated in both in vitro tests and animal models.

Treating Staphylococcus aureus infections in an intensive care unit at a University Hospital in Brazil.

Background: Optimizing antimicrobial therapy is important for treating patients who are critically ill with Staphylococcus aureus infection, and susceptibility tests are necessary.

Objective: The aim of the present study was to evaluate antibacterial therapy after susceptibility testing of S. aureus infections.

Problems related to antifungal prescription: a qualitative study of the views of intensivists.

Rationale And Objective: The choice of the appropriate antifungal medication is essential for therapeutic success. Although guidelines are available in the literature that regulate the consistent use of antifungal, no previous qualitative studies have addressed the difficulties related to the use of antifungal medication, especially in the intensive care unit (ICU). Our objective was to qualitatively investigate how intensivists consider antifungal prescriptions in an adult ICU.

Early state research on antifungal natural products.

Nosocomial infections caused by fungi have increased greatly in recent years, mainly due to the rising number of immunocompromised patients. However, the available antifungal therapeutic arsenal is limited, and the development of new drugs has been slow. Therefore, the search for alternative drugs with low resistance rates and fewer side effects remains a major challenge.

Animal models for the effective development of atrophic vaginitis therapies: possibilities and limitations.

Introduction: Vaginal atrophy (VA) is an inflammation of the vagina that develops when there is a significant decrease in levels of the estrogen. Prolonged periods of hypoestrogenism may induce severe VA and treatment is essential. This is a significant problem which requires more focused attention for the development of existing and future therapies.

[Risks of drug-nutrient interaction for the elderly in long-term care institutions].

This study was aimed at verifying the risks of drug-nutrient interactions in the elderly residents of a long-term care institution. Descriptive study of quantitative approach, performed in 73 elderly people. Data collection occurred in 2008 through analysis of medical records, diet history and evaluation of the BMI.

Utilization of fluconazole in an intensive care unit at a university hospital in Brazil.

Background: Fungi have been developing resistance and merit greater attention because these microorganisms are among the major causes of hospital infection.

Objective: The aim of the present study was to characterize the pattern of fluconazole use in an adult intensive care unit.

Setting: The setting was an intensive care unit at a university hospital in Brazil.

Trichophyton tonsurans in a family microepidemic.

Trichophyton tonsurans is a highly transmissible anthropophilic dermatophyte fungus, which invades keratinized tissues. This study reports a case of family microepidemic caused by this dermatophyte. Despite their excellent hygiene conditions, it remained active for several years, spreading to all family members.

Metabolic extract of Fusarium oxysporum induces histopathologic alterations and apoptosis in the skin of Wistar rats.

Background: Most patients with Fusarium infection present with affection of the tegumentary system, with the presence of necrotic and/or inflammatory lesions associated with pain.

Aim: To evaluate the effect of the intradermal application of a metabolic extract of Fusarium oxysporum in the skin of Wistar rats.

Methods: The extract was obtained from fungal cultivation in Czapek-Dox medium.