Reporting of offspring data in diabetes, HIV infection and hypertension trials during pregnancy: a systematic review.

Background: Clinical trials are conducted during pregnancy to evaluate benefits and risks of medicines for mother and child. The safety of maternal treatments is a key issue for healthcare professionals and parents.

Objective: To analyse offspring data reported in clinical trials in pregnant women with diabetes, HIV infection or hypertension (three of the most common diseases in women of childbearing potential) and either treated prior to pregnancy for these chronic diseases or diagnosed and treated during pregnancy.

Living network meta-analysis was feasible when considering the pace of evidence generation.

Objectives: The aim of the study was to assess the feasibility of living network meta-analysis (NMA) taking into account the pace of evidence generation across different medical areas.

Study Design And Setting: We performed a systematic review to identify published NMAs. For each NMA, we calculated the cumulative number of new trials.