Publications by authors named "Tania Knauer-Meyer"
Valproic acid (VPA) is a widely prescribed drug to treat epilepsy, bipolar disorder, and migraine. If taken during pregnancy, however, exposure to the developing embryo can cause birth defects, cognitive impairment, and autism spectrum disorder. How VPA causes these developmental defects remains unknown.
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- Young mammals can regenerate certain tissues, but this ability decreases as they mature, possibly due to cellular senescence.
- In a study of liver regeneration after partial hepatectomy, specific senescence-associated genes (p21, p16, p19) were found to be expressed differently in various cell types as regeneration capacity diminished.
- Treatment with a drug that inhibits senescence improved liver regeneration by reducing prolonged p21 expression, indicating that targeting cellular senescence may help enhance organ regeneration in young mammals.