Publications by authors named "Tania Garcia-Cedres"
Article Synopsis
- PtpA, a virulence factor from bacteria, enters macrophages during infection and influences various cellular processes like immune response and lipid metabolism by interacting with specific eukaryotic proteins including the trifunctional protein enzyme (TFP).
- The study identifies Tyr-271 in TFP as a target for PtpA's activity, which affects TFP's localization and functionality within mitochondria, and this residue is notably absent in bacterial TFPs, hinting at a regulatory mechanism unique to eukaryotes.
- The research further reveals that PtpA and TFP form a stable complex, and while Jak kinase can phosphorylate Tyr-271, additional factors are necessary to fully activate PtpA, indicating a complex