Publications by authors named "Tania Akter-Miah"
Article Synopsis
- The study focuses on idiopathic inflammatory myopathies (IIMs), which are characterized by overexpression of MHC I on muscle fibers and a distinct type I interferon (IFN) signature.
- Researchers investigated how elevated MHC-I and type I IFNs affect mitochondrial function in human skeletal muscle myoblasts, finding that MHC-I overexpression led to decreased mitochondrial respiration and other impairments, made worse when combined with IFNs.
- The findings suggest that while MHC-I alone does not increase reactive oxygen species (ROS), the addition of type I IFNs does, indicating a synergistic effect that may have important implications for understanding the mechanisms behind myositis.
The loss of muscle mass and function with age, termed sarcopenia, is an inevitable process, which has a significant impact on quality of life. During ageing we observe a progressive loss of total muscle fibres and a reduction in cross-sectional area of the remaining fibres, resulting in a significant reduction in force output. The mechanisms which underpin sarcopenia are complex and poorly understood, ranging from inflammation, dysregulation of protein metabolism and denervation.
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