Publications by authors named "Tangyao Sun"
Article Synopsis
- Photothermal therapy (PTT) can effectively target tumors and induce immunogenic cell death, but it faces challenges with solid tumors like neuroblastoma due to obstructive fibroblast presence.
- This study explores the synergistic effect of combining mesoporous platinum nanoparticles (MPNs) with the FDA-approved antihypertensive drug losartan, which helps break down the extracellular matrix (ECM) to enhance drug delivery.
- Results showed that the combination led to lower tumor cell survival, higher immune cell activation, and significant tumor suppression (around 80%), suggesting this strategy is promising for improving treatment outcomes for neuroblastoma.
The combination of noble metal nanoparticles with metal-organic complexes has attracted great attention for exploring new properties in biomedical application areas. So far, the preparation of noble metal nanoparticle-loaded metal-organic complexes often requires complex processes. Here, a simple coordination-crystallization approach was developed to prepare platinum nanoparticle-anchored metal-organic complexes (Pt-MOCs) by directly mixing disulfiram (DSF), chloroplatinic acid, and a reducing agent.
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