Publications by authors named "Tanguy Corre"
Article Synopsis
- - The study assessed the effectiveness of personalized sun protection messages, combined with a UV photograph of participants' faces, targeting adults at high risk for skin cancer in Switzerland.
- - A total of 440 participants received counseling and their sun protection habits were evaluated before and after the intervention, revealing a wide range in UV spots and showing that 61% made positive changes in their sun protection habits within three months.
- - The findings indicate that individualized messages, especially those highlighted by UV photos, significantly motivated participants to improve their sun safety behaviors despite no specific demographic factors directly correlating with this behavior change.
Weight-bearing asymmetry during sit-to-stand (STS) can cause musculoskeletal problems in people with major lower-limb amputation. Does weight-bearing asymmetry differ between individuals with major lower-limb amputation and individuals without amputation? We conducted a systematic review and meta-analysis. We searched PubMed, Cochrane Library, Web of Science, and HAL up to June 2022 using keywords and inclusion/exclusion criteria.
View Article and Find Full Text PDFBackground: Evaluation of renal function and of factors associated with its decline are important public health issues. Besides markers of glomerular function [e.g.
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- The study aims to find new genetic factors linked to variations in retinal vascular tortuosity, which could help in understanding its impact on certain diseases and their risk factors.
- The research involved analyzing a large dataset of retinal images from over 63,000 participants, utilizing advanced imaging techniques and deep learning for accurate measurement of vessel tortuosity.
- Results showed a significant connection between higher retinal tortuosity and various cardiovascular issues, leading to the identification of 175 genetic loci related to this trait, which could inform future medical studies and interventions.
: Youth alcohol use and misuse lead to adverse outcomes. However, the literature has not always associated complete abstinence with better health. Since recent literature indicates an increased proportion of young abstainers, the aim of this paper is to review the studies investigating this upward trend and the factors associated with it, such as socio-demographics, school performance, social life, physical and mental health, and parental influence.
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- Reduced glomerular filtration rate (GFR) is a precursor to kidney failure, influenced by factors like genetics and diabetes (DM), but the interaction between these factors is not well understood.
- A large-scale genome-wide association study (GWAS) analyzed eGFR across almost 1.5 million individuals, revealing distinct genetic loci that differ between those with and without diabetes.
- The findings identified potential new targets for drug development aimed at protecting kidney function, highlighting that many drug interventions could be effective for both diabetic and non-diabetic populations.
Background: Uromodulin, the most abundant protein excreted in normal urine, plays major roles in kidney physiology and disease. The mechanisms regulating the urinary excretion of uromodulin remain essentially unknown.
Methods: We conducted a meta-analysis of genome-wide association studies for raw (uUMOD) and indexed to creatinine (uUCR) urinary levels of uromodulin in 29,315 individuals of European ancestry from 13 cohorts.
Article Synopsis
- * A large study investigated blood-based DNA methylation patterns in relation to kidney function and found 69 DNA sites linked to estimated glomerular filtration rate and 7 to urinary albumin-to-creatinine ratio, pointing to potential genetic markers for CKD.
- * Further validation in kidney tissue highlighted specific genes associated with kidney function and suggested that certain DNA methylation changes could have causal effects, implicating pathways in blood cell migration and immune response related to kidney health.
Article Synopsis
- * The study identified 100 significant CpG sites that account for 11.6% of serum urate variance, particularly noting five CpGs associated with SLC2A9, a major gene influencing serum urate levels.
- * Additionally, some of these CpGs also appear to mediate effects of genetic variants related to serum urate and are linked to metabolic syndrome, suggesting a potential blood DNA methylation signature for assessing cardiometabolic risk factors.
Background: Variability in ultrafiltration influences prescriptions and outcomes in patients with kidney failure who are treated with peritoneal dialysis. Variants in , the gene that encodes the archetypal water channel aquaporin-1, may contribute to that variability.
Methods: We gathered clinical and genetic data from 1851 patients treated with peritoneal dialysis in seven cohorts to determine whether variants were associated with peritoneal ultrafiltration and with a risk of the composite of death or technique failure (i.
Article Synopsis
- This research identifies 290 genetic factors linked to ovarian ageing by analyzing the age at natural menopause in 200,000 European women, highlighting how genetics can influence reproductive lifespan.* -
- The study reveals that these genetic variants are connected to DNA damage response processes that impact ovarian reserve and depletion rates, suggesting potential therapeutic targets.* -
- Manipulating these pathways in experimental models showed promise in boosting fertility and extending reproductive longevity, while also indicating benefits and risks for women's overall health, such as improved bone health but increased cancer risk.*
In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (F) for >1.
View Article and Find Full Text PDFElevated serum urate levels cause gout and correlate with cardiometabolic diseases via poorly understood mechanisms. We performed a trans-ancestry genome-wide association study of serum urate in 457,690 individuals, identifying 183 loci (147 previously unknown) that improve the prediction of gout in an independent cohort of 334,880 individuals. Serum urate showed significant genetic correlations with many cardiometabolic traits, with genetic causality analyses supporting a substantial role for pleiotropy.
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- Increased urinary albumin-to-creatinine ratio (UACR) is linked to higher risks of kidney disease and cardiovascular issues, yet the underlying causes are not fully understood.
- A large meta-analysis identified 68 genetic loci associated with UACR, highlighting connections to conditions like proteinuria, hyperlipidemia, and hypertension.
- Specific genes (such as TGFB1 and PRKCI) were implicated in kidney function, and experiments showed that disrupting these genes in fruit flies affects albumin processing, suggesting new avenues for research to lower albumin levels.
Article Synopsis
- - The study investigates the genetic factors linked to changes in fasting glucose levels over time in nearly 13,807 non-diabetic individuals of European descent, aiming to understand elements that could lead to Type 2 diabetes (T2D).
- - Researchers found no strong genetic associations (defined as genome-wide significance) with fasting glucose changes, suggesting that any genetic influences are likely to be minimal.
- - Several genetic loci previously connected to T2D and glucose levels showed nominal associations, and the data collected will serve as a resource for future research on genetic links to T2D and other metabolic traits.
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through trans-ancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these, 147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178).
View Article and Find Full Text PDFNegative effect of vitamin D on kidney function: a Mendelian randomization study.
Nephrol Dial Transplant
December 2018
Background: The kidney plays a central role in the regulation of vitamin D metabolism. It is not clear, however, whether vitamin D influences kidney function. Previous studies have reported conflicting results, which may have been influenced by reverse causation and residual confounding.
View Article and Find Full Text PDFMagnesium (Mg) homeostasis is critical for metabolism. However, the genetic determinants of the renal handling of Mg, which is crucial for Mg homeostasis, and the potential influence on metabolic traits in the general population are unknown. We obtained plasma and urine parameters from 9099 individuals from seven cohorts, and conducted a genome-wide meta-analysis of Mg homeostasis.
View Article and Find Full Text PDFDepression and obesity are highly prevalent, and major impacts on public health frequently co-occur. Recently, we reported that having depression moderates the effect of the gene, suggesting its implication in the association between depression and obesity.To confirm these findings by investigating the polymorphism rs9939609 in new cohorts, and subsequently in a meta-analysis.
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- Physical activity (PA) can influence genetic factors linked to obesity, leading to a deeper understanding of how genetics and lifestyle interact in shaping body fat.
- A study involving over 200,000 adults analyzed the relationship between PA and various obesity-related measurements, confirming that the impact of the FTO gene is reduced in physically active individuals.
- The research also discovered 11 new genetic regions associated with body fat, indicating that considering lifestyle factors like PA can help uncover more genetic links to obesity.
Article Synopsis
- Many genome-wide association studies (GWAS) often overlook environmental factors like smoking, which might affect the genetic analysis of obesity traits.
- This study analyzed GWAS data from over 240,000 participants, including smokers and nonsmokers, to find genetic links to body mass index (BMI) and body fat distribution.
- The researchers identified 23 new genetic loci related to obesity and 9 loci that interact with smoking, suggesting that smoking can influence genetic predispositions to body fat.
Article Synopsis
- - The research identifies 389 genetic signals related to the timing of menarche (first menstrual period) in up to 370,000 women, showing how genetics influence this aspect of puberty and link it to adult diseases.
- - Findings indicate that about 7.4% of the population variation in menarche age can be explained by these genetic signals, with a notable enrichment of associated genes in neural tissues.
- - The study suggests that the timing of puberty has causal relationships with certain cancers, independently of factors like body mass index (BMI), highlighting the intricate genetic factors influencing puberty and its long-term health effects.
Disorders of water balance, an excess or deficit of total body water relative to body electrolyte content, are common and ascertained by plasma hypo- or hypernatremia, respectively. We performed a two-stage genome-wide association study meta-analysis on plasma sodium concentration in 45,889 individuals of European descent (stage 1 discovery) and 17,637 additional individuals of European descent (stage 2 replication), and a transethnic meta-analysis of replicated single-nucleotide polymorphisms in 79,506 individuals (63,526 individuals of European descent, 8765 individuals of Asian Indian descent, and 7215 individuals of African descent). In stage 1, we identified eight loci associated with plasma sodium concentration at <5.
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