Publications by authors named "Tanguturi Venkata Narayana Hajay Kumar"
We previously showed that the anti-fungal drug ciclopirox olamine effectively inhibits replication of herpes simplex virus (HSV)-1 and HSV-2. Given the rise of HSV strains that are resistant to nucleos(t)ide analog treatment, as well as the incomplete efficacy of nucleos(t)ide analogs, new inhibitory compounds must be explored for potential use in the treatment of HSV infection. In the present study, we analyzed 44 compounds derived from the core structure of ciclopirox olamine for inhibitory activity against HSV.
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- Opportunistic fungal infections significantly impact immunocompromised patients, highlighting the need for more effective antifungal therapies due to limited existing options.
- Ciclopirox olamine, a known antifungal, has led to the synthesis of ten new -hydroxypyridone derivatives to explore their potential for systemic use against various fungal species.
- Eight of the derivatives demonstrated antifungal activity at low concentrations while showing synergies with other antifungals, indicating promising starting points for developing improved treatments targeting these infections.